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Cristina Vercelli,Raffaella Barbero,Barbara Cuniberti,Silvia Racca,Giuliana Abbadessa,Francesca Piccione,Giovanni Re 한국유방암학회 2014 Journal of breast cancer Vol.17 No.4
Purpose: Transient receptor potential vanilloid 1 (TRPV1) is a nonselectivecation channel belonging to the transient receptor potentialfamily, and it is expressed in different neoplastic tissues. Its activation is associated with regulation of cancer growth andprogression. The aim of this research was to study the expressionand pharmacological characteristics of TRPV1 in cells derivedfrom human breast cancer MCF-7 cells. Methods: TRPV1presence was assessed by binding studies and Western blotting. Receptor binding characteristics were evaluated through competitionassays, while 3-(4,5-dimethylthiazol-2-yl)-2,5,-dipheyltetrazoliumbromide reduction assays were performed to confirman early hypothesis regarding the modulation of cancer cell proliferation. The functionality of TRPV1 was evaluated by measuringCa2+ uptake in the presence of increasing concentrations ofTRPV1 agonists and antagonists. Results: Binding studies identifieda single class of TRPV1 (Bmax 1,492±192 fmol/mg protein),and Western blot showed a signal at 100 kDa corresponding tothe molecular weight of human TRPV1. Among the different testedagonists and antagonists, anandamide (Ki: 2.8×10-11 M) and5-iodoresiniferatoxin (5-I-RTX) (Ki: 5.6×10-11 M) showed the highestdegrees of affinity for TRPV1, respectively. All tested TRPV1agonists and antagonists caused a significant (p<0.05) decreasein cell growth rate in MCF-7 cells. For agonists and antagonists,the efficacy of tested compounds displayed the following rankorder: resiniferatoxin>anandamide>capsaicin and 5-I-RTX=capsazepine, respectively. Conclusion: These data indicate thatboth TRPV1 agonists and antagonists induce significant inhibitionof MCF-7 cell growth. Even though the mechanisms involvedin the antiproliferative effects of TRPV1 agonists and antagonistsshould be further investigated, it has been suggestedthat agonists cause desensitization of the receptor, leading to alterationin Ca2+-influx regulation. By contrast, antagonists causea functional block of the receptor with consequent fatal dysregulationof cell homeostasis.
Search for lepton flavor violating <sup>τ−</sup> decays with a KS0 meson
Miyazaki, Y.,Abe, K.,Abe, K.,Aihara, H.,Anipko, D.,Arinstein, K.,Aulchenko, V.,Aushev, T.,Bakich, A.M.,Barbero, M.,Bedny, I.,Belous, K.,Bitenc, U.,Bizjak, I.,Blyth, S.,Bondar, A.,Bozek, A.,Brač,k Elsevier 2006 Physics letters: B Vol.639 No.3
<P><B>Abstract</B></P><P>We have searched for the lepton flavor violating decays <SUP>τ−</SUP>→<SUP>ℓ−</SUP>KS0 (ℓ=e or <I>μ</I>), using a data sample of 281 fb<SUP>−1</SUP> collected with the Belle detector at the KEKB <SUP>e+</SUP><SUP>e−</SUP> asymmetric-energy collider. No evidence for a signal was found in either of the decay modes, and we set the following upper limits for the branching fractions: B(<SUP>τ−</SUP>→<SUP>e−</SUP>KS0)<5.6×<SUP>10−8</SUP> and B(<SUP>τ−</SUP>→<SUP>μ−</SUP>KS0)<4.9×<SUP>10−8</SUP> at the 90% confidence level. These results improve the previously published limits set by the CLEO Collaboration by factors of 16 and 19, respectively.</P>
Monitoring the activities of Italian colposcopy clinics before and during the COVID-19 pandemic
Giovanni Delli Carpini,Paolo Giorgi Rossi,Luca Giannella,Jacopo Di Giuseppe,Nicolò Clemente,Francesco Sopracordevole,Maggiorino Barbero,Giorgio Bogani,Rosa De Vincenzo,Massimo Origoni,Francesco Cantat 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.1
Objective: To evaluate the impact of healthcare reorganization during the severe acute respiratory syndrome coronavirus 2 pandemic on Italian colposcopy clinic activities, focusing on cervical excision procedures, follow-ups for conservative management of low-grade lesions, and follow-ups post cervical excision. Methods: Retrospective study conducted in 14 Italian colposcopy clinics. The number and clinical characteristics of cervical excisions, follow-ups for conservative management of low-grade lesions, and follow-ups after cervical excision were compared between the period March 1, 2019 to February 29, 2020 (pre-pandemic) and March 1, 2020 to February 28, 2021 (pandemic) with a Poisson regression analysis. Results: In the pandemic period, the number of cervical excisions was reduced by 8.8% (95% confidence interval [CI]=−15.6% to −2%; p=0.011). Excisions were less frequently performed in the operating room (−35.1%; 95% CI=−47.6% to −22.6%; p<0.001), the number of patients from spontaneous screening was reduced by −14.0% (95% CI=−23.4% to −4.6%; p=0.003), and the CO2-laser technique was used less frequently (−30%; 95% CI=−45.1% to −15.0%; p<0.001). As compared to the pre-pandemic period, the number of follow-ups for conservative management of low-grade lesions was reduced by −26.7% (95% CI=−39.0% to −14.4%; p<0.001), and the follow-up appointments after cervical excision were reduced by −51.0% (95% CI=−58.1% to −43.9%; p<0.001). Conclusion: The most significant impact of the healthcare reorganization during the coronavirus disease 2019 pandemic was on follow-ups after cervical excision. The resumption of disrupted activities should follow a risk-based prioritization, starting from women in follow-up after cervical excision. It is advisable that the trend of performing cervical excision as an outpatient procedure is maintained in the post-pandemic period.
Search forD0−D¯0mixing using semileptonic decays at Belle
Bitenc, U.,Abe, K.,Abe, K.,Adachi, I.,Aihara, H.,Asano, Y.,Aushev, T.,Bahinipati, S.,Banerjee, S.,Barberio, E.,Barbero, M.,Bedny, I.,Bizjak, I.,Blyth, S.,Bondar, A.,Bozek, A.,Brač,ko, M.,Brodzick American Physical Society 2005 PHYSICAL REVIEW D - Vol.72 No.7
Belle Collaboration,Hokuue, T.,Abe, K.,Abe, K.,Adachi, I.,Aihara, H.,Asano, Y.,Aushev, T.,Bakich, A.M.,Balagura, V.,Barberio, E.,Barbero, M.,Bay, A.,Bedny, I.,Belous, K.,Bitenc, U.,Bizjak, I.,Blyth, S North-Holland Pub. Co 2007 Physics letters: B Vol.648 No.2
We report measurements of the charmless semileptonic decays B<SUP>0</SUP>->π<SUP>-</SUP>/ρ<SUP>-</SUP>@?<SUP>+</SUP>ν and B<SUP>+</SUP>->π<SUP>0</SUP>/ρ<SUP>0</SUP>@?<SUP>+</SUP>ν, based on a sample of 2.75x10<SUP>8</SUP>BB@? events collected at the @?(4S) resonance with the Belle detector at the KEKB e<SUP>+</SUP>e<SUP>-</SUP> asymmetric collider. In this analysis, the accompanying B meson is reconstructed in the semileptonic mode B->D<SUP>(*)</SUP>@?ν, enabling detection of the signal modes with high purity. We measure the branching fractions B(B<SUP>0</SUP>->π<SUP>-</SUP>@?<SUP>+</SUP>ν)=(1.38+/-0.19+/-0.14+/-0.03)x10<SUP>-4</SUP>, B(B<SUP>0</SUP>->ρ<SUP>-</SUP>@?<SUP>+</SUP>ν)=(2.17+/-0.54+/-0.31+/-0.08)x10<SUP>-4</SUP>, B(B<SUP>+</SUP>->π<SUP>0</SUP>@?<SUP>+</SUP>ν)=(0.77+/-0.14+/-0.08+/-0.00)x10<SUP>-4</SUP> and B(B<SUP>+</SUP>->ρ<SUP>0</SUP>@?<SUP>+</SUP>ν)=(1.33+/-0.23+/-0.17+/-0.05)x10<SUP>-4</SUP>, where the errors are statistical, experimental systematic, and systematic due to form factor uncertainties, respectively. For each mode we also present the partial branching fractions in three q<SUP>2</SUP> intervals: q<SUP>2</SUP><8, 8=<q<SUP>2</SUP><16, and q<SUP>2</SUP>>=16 GeV<SUP>2</SUP>/c<SUP>2</SUP>. From our partial branching fractions for B->π@?ν and recent results for the form factor from unquenched Lattice QCD calculations, we obtain values of the CKM matrix element |V<SUB>ub</SUB>|.