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- 저자 : Bagnasco, Francesco (검색결과 5 건)
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Personalized Medicine in Allergy
Matteo Ferrando,Diego Bagnasco,Gilda Varricchi,Stefano Bernardi,Alice Bragantini,Giovanni Passalacqua,Giorgio Walter Canonica 대한천식알레르기학회 2017 Allergy, Asthma & Immunology Research Vol.9 No.1
Allergic disease is among the most common pathologies worldwide and its prevalence has constantly increased up to the present days, even if according to the most recent data it seems to be slightly slowing down. Allergic disease has not only a high rate of misdiagnosis and therapeutic inefficacy, but represents an enormous, resource-absorbing black hole in respiratory and general medicine. The aim of this paper is to summarize principal therapeutic innovations in atopic disease management befallen in the recent years in terms of personalized/precision medicine.
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Predictive Analysis of the ITER Poloidal Field Conductor Insert (PFCI) Test Program
Zanino, R.,Astrov, M.,Bagnasco, M.,Baker, W.,Bellina, F.,Ciazynski, D.,Egorov, S.,Kim, K.,Kvitkovic, J.L.,Lacroix, B.,Martovetsky, N.,Mitchell, N.,Muzzi, L.,Nunoya, Y.,Okuno, K.,Polak, M.,Ribani, P.L. IEEE 2007 IEEE transactions on applied superconductivity Vol.17 No.2
<P>In this paper, we discuss the predictive analysis performed in support of the test program of the International Thermonuclear Experimental Reactor (ITER) poloidal field conductor insert (PFCI). A subset of the test program items was considered, with particular emphasis on DC performance and AC losses. The results and implications of the comparison of selected predictions from different laboratories will be presented.</P>
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STEFANO PARODI,Verda Damiano,Bagnasco Francesca,Muselli Marco 한국역학회 2022 Epidemiology and Health Vol.44 No.-
The area under a receiver operating characteristic (ROC) curve (AUC) is a popular measure of pure diagnostic accuracy that is independent from the proportion of diseased subjects in the analysed sample. However, its actual usefulness in the clinical context has been questioned, because it does not seem to be directly related to the actual performance of a diagnostic marker in identifying diseased and non-diseased subjects in real clinical settings. This study evaluates the relationship between the AUC and the proportion of correct classifications (global diagnostic accuracy, GDA) in relation to the shape of the corresponding ROC curves. We demonstrate that AUC represents an upward-biased measure of GDA at an optimal accuracy cut-off for balanced groups. The magnitude of bias depends on the shape of the ROC plot and on the proportion of diseased and non-diseased subjects. In proper curves, the bias is independent from the diseased/non-diseased ratio and can be easily estimated and removed. Moreover, a comparison between 2 partial AUCs can be replaced by a more powerful test for the corresponding whole AUCs. Applications to 3 real datasets are provided: a marker for a hormone deficit in children, 2 tumour markers for malignant mesothelioma, and 2 gene expression profiles in ovarian cancer patients. In conclusion, the AUC is a measure of accuracy with potential clinical relevance for the evaluation of disease markers. The clinical meaning of ROC parameters should always be evaluated with an analysis of the shape of the corresponding ROC curve.
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Setti, Paolo,Pesce, Paolo,Dellepiane, Elena,Bagnasco, Francesco,Zunino, Paola,Menini, Maria Korean Academy of Periodontology 2020 Journal of Periodontal & Implant Science Vol.50 No.5
Purpose: This pilot study was conducted to evaluate the cleaning efficacy of an angled implant brush for home oral hygiene of full-arch fixed-implant prostheses. Methods: Forty-one patients treated with a full-arch implant rehabilitation in the maxilla or mandible (164 implants) for at least 4 months were enrolled. The screw-retained fixed prostheses were removed and baseline (T0) parameters were recorded, including plaque index (PI), probing depth (PD), and bleeding on probing (BOP). All patients completed a 5-item questionnaire on hygiene maintenance and received an implant brush for home hygiene. After 1 month (T1) PI, PD, and BOP were recorded again and patients completed a 7-item questionnaire to evaluate their satisfaction with the implant brush. One-way repeated-measures analysis of variance was conducted to evaluate the significance of changes in PI, PD, and BOP. A P value <0.05 was considered to indicate statistical significance. Results: A statistically significant reduction of BOP (0.62±0.6 at T0 vs. 0.5±0.5 at T1; P=0.032) was found, while no statistically significant changes in PD (1.74±0.5 mm at T0 vs. 1.77±0.5 mm at T1; P=0.050) or PI (1.9±0.7 at T0 vs. 1.7±0.7 at T1; P=0.280) occurred. According to the 7-item questionnaire, patients reported no difficulty in using the angled brush (63.4%) and deemed it highly (46.3%) or very highly (4.8%) effective in improving their home oral hygiene. Conclusions: Within the limits of the present pilot study, the patients experienced a reduction of BOP 1 month after being instructed to use the angled implant brush. The angled implant brush appeared to be a well-accepted device for home-care hygiene of full-arch fixed-implant rehabilitations.
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Preparation of the ITER poloidal field conductor insert (PFCI) test
Zanino, R.,Egorov, S.,Kim, K.,Martovetsky, N.,Nunoya, Y.,Okuno, K.,Salpietro, E.,Sborchia, C.,Takahashi, Y.,Weng, P.,Bagnasco, M.,Richard, L.S.,Polak, M.,Formisano, A.,Zapretilina, E.,Shikov, A.,Veder IEEE 2005 IEEE transactions on applied superconductivity Vol.15 No.2
The Poloidal Field Conductor Insert (PFCI) of the International Thermonuclear Experimental Reactor (ITER) has been designed in the EU and is being manufactured at Tesla Engineering, UK, in the frame of a Task Agreement with the ITER International Team. Completion of the PFCI is expected at the beginning of 2005. Then, the coil shall be shipped to JAERI Naka, Japan, and inserted into the bore of the ITER Central Solenoid Model Coil, where it should be tested in 2005 to 2006. The PFCI consists of a NbTi dual-channel conductor, almost identical to the ITER PF1 and PF6 design, ∼45 m long, with a 50 mm thick square stainless steel jacket, wound in a single-layer solenoid. It should carry up to 50 kA in a field of ∼6 T, and it will be cooled by supercritical He at ∼4.5 K and ∼0.6 MPa. An intermediate joint, representative of the ITER PF joints and located at relatively high field, will be an important new item in the test configuration with respect to the previous ITER Insert Coils. The PFCI will be fully instrumented with inductive and resistive heaters, as well as with voltage taps, Hall probes, pick-up coils, temperature sensors, pressure gauges, strain and displacement sensors. The test program will be aimed at DC and pulsed performance assessment of conductor and intermediate joint, AC loss measurement, stability and quench propagation, thermal-hydraulic characterization. Here we give an overview of the preparatory work toward the test, including a review of the coil manufacturing and of the available instrumentation, a discussion of the most likely test program items, and a presentation of the supporting modeling and characterization work performed so far.
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