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Assessment of Breast Cancer Patients' Knowledge and Decisional Conflict Regarding Tamoxifen Use
Kim, Se Ik,Lee, Yumi,Son, Yedong,Jun, So Yeun,Yun, Sooin,Bae, Hyo Sook,Lim, Myong Cheol,Jung, So-Youn,Joo, Jungnam,Lee, Eun Sook The Korean Academy of Medical Sciences 2015 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.30 No.11
<P>Breast cancer is the most common type of female cancer. Tamoxifen, a selective estrogen receptor modulator, is widely used to decrease breast cancer recurrence and mortality among patients. However, it also increases the risk of endometrial cancer. This study aimed to assess knowledge and decisional conflict regarding tamoxifen use. Between June and October 2014, breast cancer patients using tamoxifen were consecutively screened and requested to complete a survey including the EQ-5D, Satisfaction with Decision Scale (SWD), Decisional Conflict Scale (DCS), and a self-developed, 15-item questionnaire measuring tamoxifen-related knowledge. The study sample comprised 299 patients. The mean total knowledge score was 63.4 of a possible 100.0 (range, 13.3-93.3). While 73.9% of the participants knew that tamoxifen reduces the risk of breast cancer recurrence, only 57.9% knew that the drug increases endometrial cancer risk. A higher education level (≥college) was associated with a higher, total knowledge score (β = 4.291; <I>P</I> = 0.017). A higher knowledge score was associated with a decreased DCS score (β = -0.366; <I>P</I> < 0.001). A higher SWD score was also associated with decreased decisional conflict (β = -0.178; <I>P</I> < 0.001). In conclusion, the breast cancer patients with higher levels of tamoxifen-related knowledge showed lower levels of decisional conflict regarding tamoxifen use. Clinicians should provide the exact information about tamoxifen treatment to patients, based on knowledge assessment results, so as to aid patients' decision-making with minimal conflict.</P>
배정익(Bae, Jung-Ik),안병욱(An, Byung-Wook),박동소(Park, Tong-So),이상호(Lee, Sang-Ho),이경회(Lee, Kyung-Hoi) 한국교육시설학회 1998 敎育施設 Vol.5 No.1
Nowadays, social environment is rapidly changed toward globalization and information age, and which demands the new paradigm for active utilization of information system in the field of education and many others. The effort to adapt tele-communication technique to educational facilities and the planning to make virtual university come true are needed immediately. Intelligent Building system should be applied to educational facilities to cope with the changing and progressing building system. As a result of the surveying eleven domestic universities, it was found that library management system, administration automation system and office automation system were already introduced, but campus infrastructure such as network system and tele-communication system between buildings in campus have been constructed now. As the conclusion of this study, impeding factors and improvement direction for active utilization of intelligent building systems in university facilities were presented.
Molecular Systematics of Korean Cobitids Based on Mitochondrial Cytochrome b Sequence
Kim, So-Young,Kim, Chang-Bae,Kim, Ik-Soo,Park, Jong-Young,Park, Ho-Yong The Korean Society for Integrative Biology 2002 Korean journal of biological sciences Vol.6 No.1
We compared the complete mitochondrial cytochrome b gene sequences of Korean and European cobitids to provide independent evidence for assessment of systematic and biogeographic relationships of species in the genus Cobitis. The data suggested monophyly of the genus Cobitis and the inclusion of Korean Cobitis species within the group having one lamina circularis, a primitive condition. Also, all the phylogenetic analyses using maximum parsimony, maximum likelihood, and neighbor joining methods showed a monophyletic relationship among Cobitis. The basal position of the Caspian C. cf. sibirica reported here reflects the eastern Asiatic origin cf. the European Cobitis and establishes C. cf. sibirica as an independent lineage. The Korean C. pacifica diverged next to C. cf. sibirica in basal group from the genus Cobitis. This result is in agreement with the hypothesized Asiatic origin of some European freshwater fish lineages. The phylogenetic relationships in this study showed a close affinity between C. zanadreai and C. sinensis. Two new species, C. tetralineata and C. pacifica in Korea also are closely related to monophyletic group clustering the type species of the Acanestrinia subgenus (C. elongata) with all the endemic Italian species (C. bilineata and C. zanandreai). This may suggest that the affinity between the Korean and Danubian-Italian imply genetic convergence or genetic plesiomorphic state between allopatric species that are separated for the Miocene. The mtDNA-based phylogeny for the species of the genus Cobitis from Kores and Europe permits phylogenetic assessment of the morphological transitions of Iamina circularis.
Effects of CYP2D6 genetic polymorphism on the pharmacokinetics of metoclopramide
Jung‑Woo Bae,Kyung‑Yul Oh,So‑Jung Yoon,Hyo‑Bin Shin,Eui Hyun Jung,Chang‑Keun Cho,Chang Woo Lim,Pureum Kang,Chang‑Ik Choi,Choon‑Gon Jang,Seok‑Yong Lee,Yun Jeong Lee 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.11
Metoclopramide inhibits the central and peripheralD2receptors and is frequently prescribed in adults andchildren as an antiemetic or a prokinetic drug to controlsymptoms of upper gastrointestinal motor disorders. Metoclopramideis predominantly metabolized via N-dealkylationand it is primarily mediated by CYP2D6 which is highlypolymorphic. Thus, the effects of CYP2D6 genetic polymorphismon the pharmacokinetics of metoclopramide wereevaluated in this study. All volunteers were genotyped forCYP2D6 and divided into four different genotype groups(CYP2D6*wt/*wt [*wt = *1 or *2], CYP2D6*wt/*10,CYP2D6*10/*10, and CYP2D6*5/*10). Each subjectreceived a single oral dose of metoclopramide 10 mg. Plasma concentrations of metoclopramide were measuredby using HPLC-UV. Compared to CYP2D6*wt/*wt, AUC infof CYP2D6*wt/*10, CYP2D6*10/*10, and CYP2D6*5/*10significantly increased by 1.5-, 2.3-, and 2.5-fold, respectively. Cmaxalso increased significantly in comparison toCYP2D6*wt/*wt across all genotype groups, with 1.5-, 1.7-, and 1.7-fold increases seen in CYP2D6*wt/*10,CYP2D6*10/*10, and CYP2D6*5/*10 groups, respectively. The CL/F of metoclopramide decreased in CYP2D6 genotypegroups with decreased function alleles, as decreasesof 37%, 56% and 61% were observed in CYP2D6*wt/10,*10/10, and *5/*10 genotype groups in comparison to theCYP2D6*wt/*wt group. In conclusion, the genetic polymorphismsof CYP2D6 significantly affected metoclopramidepharmacokinetics.
Yang, Yi,Bae, Woo Kyun,Nam, Sang-Jip,Jeong, Min-Hye,Zhou, Rui,Park, So-Yeon,Taş,, İ,sa,Hwang, Yun-Ho,Park, Myong-Suk,Chung, Ik Joo,Kim, Kyung Keun,Hur, Jae-Seoun,Kim, Hangun Elsevier 2018 Phytomedicine Vol.40 No.-
<P>Conclusion: The endolichenic fungus EL002332 has potential anticancer activity in gastric cancer and peritoneal carcinomatosis.</P>