http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Bae Kyungsoo,Oh Dong Yul,Yun Il Dong,Jeon Kyung Nyeo 대한영상의학회 2022 Korean Journal of Radiology Vol.23 No.1
Objective: To compare the effects of bone suppression imaging using deep learning (BSp-DL) based on a generative adversarial network (GAN) and bone subtraction imaging using a dual energy technique (BSt-DE) on radiologists’ performance for pulmonary nodule detection on chest radiographs (CXRs). Materials and Methods: A total of 111 adults, including 49 patients with 83 pulmonary nodules, who underwent both CXR using the dual energy technique and chest CT, were enrolled. Using CT as a reference, two independent radiologists evaluated CXR images for the presence or absence of pulmonary nodules in three reading sessions (standard CXR, BSt-DE CXR, and BSp-DL CXR). Person-wise and nodule-wise performances were assessed using receiver-operating characteristic (ROC) and alternative free-response ROC (AFROC) curve analyses, respectively. Subgroup analyses based on nodule size, location, and the presence of overlapping bones were performed. Results: BSt-DE with an area under the AFROC curve (AUAFROC) of 0.996 and 0.976 for readers 1 and 2, respectively, and BSp-DL with AUAFROC of 0.981 and 0.958, respectively, showed better nodule-wise performance than standard CXR (AUAFROC of 0.907 and 0.808, respectively; p ≤ 0.005). In the person-wise analysis, BSp-DL with an area under the ROC curve (AUROC) of 0.984 and 0.931 for readers 1 and 2, respectively, showed better performance than standard CXR (AUROC of 0.915 and 0.798, respectively; p ≤ 0.011) and comparable performance to BSt-DE (AUROC of 0.988 and 0.974; p ≥ 0.064). BSt-DE and BSp-DL were superior to standard CXR for detecting nodules overlapping with bones (p < 0.017) or in the upper/middle lung zone (p < 0.017). BSt-DE was superior (p < 0.017) to BSp-DL in detecting peripheral and sub-centimeter nodules. Conclusion: BSp-DL (GAN-based bone suppression) showed comparable performance to BSt-DE and can improve radiologists’ performance in detecting pulmonary nodules on CXRs. Nevertheless, for better delineation of small and peripheral nodules, further technical improvements are required.
Bang, Hyun Bae,Lee, Kyungsoo,Lee, Yong Jae,Jeong, Ki Jun Elsevier 2018 PROCESS BIOCHEMISTRY Vol.68 No.-
<P><B>Abstract</B></P> <P> <I>Trans</I>-cinnamic acid is a phenylpropanoid that is widely used in cosmetics, anti-bacterial compounds, anti-cancer, and flavoring agents. Previously, we succeeded in the generation of L-phenylalanine-high producing <I>Escherichia coli</I> strain by metabolic engineering of the L-phenylalanine biosynthesis pathway. Using this engineered strain, in this study, we developed an <I>E. coli</I> platform for the enhanced production of <I>trans</I>-cinnamic acid that can be generated from L-phenylalanine by phenylalanine ammonia-lyase (PAL)-mediated deamination reaction. To increase the production titer of <I>trans</I>-cinnamic acid, three different promoters and four different nutrient solutions were examined and, using the optimized system (gene expression under Trc promoter and supplementation of casamino acid), we achieved the production of <I>trans</I>-cinnamic acid as high as 697 mgL<SUP>−1</SUP> in shake flask cultivation. Finally, pH-stat fed-batch fermentations were performed in a lab-scale (2 L) bioreactor with three different feeding solutions (glucose, yeast extract, and casamino acid). When casamino acid was supplied as feeding solution, the production of <I>trans</I>-cinnamic acid as high as 6.9 gL<SUP>−1</SUP> was achieved.</P> <P><B>Highlights</B></P> <P> <UL> <LI> <I>Trans</I>-cinnamic acid has been widely used with various applications. </LI> <LI> <I>Trans</I>-cinnamic acid pathway was reconstructed by optimization of PAL gene expression in <I>E. coli</I>. </LI> <LI> With the engineered strain, 650 mg/L <I>trans</I>-cinnamic acid was produced in flask cultivation. </LI> <LI> By the optimization of feeding solution, <I>trans</I>-cinnamic acid could be produced as high as 6.9 g/L in fed-batch cultivation. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Sang-Ho Jeong,Kyungsoo Bae,Chang-Youn Ha,Young-Joon Lee,Ok-Jae Lee,Woon-Tae Jung,Sang-Kyung Choi,Soon-Chan Hong,Eun-Jung Jung,Young-Tae Ju,Chi-Young Jeong,Woo-Song Ha 대한외과학회 2013 Annals of Surgical Treatment and Research(ASRT) Vol.84 No.2
Purpose: Before laparoscopic gastrectomy for gastric cancer can be planned, it is very important to know the precise location of the tumor. The aim of this study was to evaluate 3 methods of predicting the exact location of the tumor: preoperative gastrofibroscopy (GFS), preoperative computed tomography gastroscopy (CT), and intraoperative gastroscopy-guided laparoscopy (Lap). Methods: In this study, 15 patients were prospectively identified, and endoscopic clips were preoperatively placed on the proximal 1 cm of the tumor, at the angle on the greater curvature and opposite the angle on the greater curvature. The distances between the pylorus and the proximal tumor clip (PT), the angle clip (PA), the greater curvature clip (PG), and the gastroesophageal junction were measured by preoperative GFS, preoperative CT, intraoperative Lap, and visual inspection (Vis). Results: PT, PA, and PG values measured by preoperative GFS differed significantly from the Vis values (P 〈 0.01). However, preoperative CT measurements of PT, PA, and PG did not differ from the Vis values (P = 0.78, P = 0.48, and P = 0.53, respectively). Intraoperative Lap and Vis PT values differed by only 1.1 cm on an average (P = 0.10), but PA and PG values varied by 1.9 and 3.4 cm, respectively (P = 0.01 for both). Conclusion: Endoscopic clipping combined with preoperative CT gastroscopy is more useful than preoperative GFS for preoperatively predicting the location of early gastric cancers and will be helpful for planning laparoscopic gastrectomy.
Jeong, Sang-Ho,Lee, Young-Joon,Bae, Kyungsoo,Ha, Woo-Song,Park, Soon-Tae,Choi, Sang-Kyung,Hong, Soon-Chan,Jung, Eun-Jung,Joo, Young-Tae,Jeong, Chi-Young Mary Ann Liebert 2009 Journal of Laparoendoscopic & Advanced Surgical Te Vol.19 No.2
<P>This study investigated the factors affecting the length of the minilaparotomy incision (LOMI) in laparoscopy-assisted distal gastrectomy with Billroth I reconstruction. By using abdominal computed tomography scans, we measured the thickness of the rectus muscle (TRM), the thickness of the abdominal wall (TAW), and the distance from the gastroduodenal artery to the skin (GDAS) in 80 patients with early gastric cancer who had undergone surgery. There were positive correlations between the LOMI and body mass index (BMI), TRM, and TAW, and the LOMI increased significantly in patients with BMI > or =25 kg/m2, TAW > or =2.1 cm, and TRM > or =1.0 cm. These observations suggest that patients with two or more of the following clinical factors, BMI > or =25 kg/m2, TAW > or =2.1 cm, and TRM > or =1.0 cm, may require surgical procedures other than laparoscopy-assisted Billroth I, such as total laparoscopic intracorporeal Billroth I, Billroth II, or uncut Roux-en-Y reconstruction.</P>