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Expression patterns of astrocyte elevated gene-1 (AEG-1) during development of the mouse embryo
Jeon, Hyun Yong,Choi, Murim,Howlett, Eric L.,Vozhilla, Nikollaq,Yoo, Byoung Kwon,Lloyd, Joyce A.,Sarkar, Devanand,Lee, Seok-Geun,Fisher, Paul B. Elsevier 2010 Gene expression patterns Vol.10 No.7
<P><B>Abstract</B></P><P>Expression of astrocyte elevated gene-1 (AEG-1) is elevated in multiple human cancers including brain tumors, neuroblastomas, melanomas, breast cancers, non-small cell lung cancers, liver cancers, prostate cancers, and esophageal cancers. This gene plays crucial roles in tumor cell growth, invasion, angiogenesis and progression to metastasis. In addition, over-expression of AEG-1 protects primary and transformed cells from apoptosis-inducing signals by activating PI3K-Akt signaling pathways. These results suggest that AEG-1 is intimately involved in tumorigenesis and may serve as a potential therapeutic target for various human cancers. However, the normal physiological functions of AEG-1 require clarification. We presently analyzed the expression pattern of AEG-1 during mouse development. AEG-1 was expressed in mid-to-hindbrain, fronto-nasal processes, limbs, and pharyngeal arches in the early developmental period from E8.5 to E9.5. In addition, at stages of E12.5–E18.5 AEG-1 was localized in the brain, and olfactory and skeletal systems suggesting a role in neurogenesis, as well as in skin, including hair follicles, and in the liver, which are organ sites in which AEG-1 has been implicated in tumor development and progression. AEG-1 co-localized with Ki-67, indicating a role in cell proliferation, as previously revealed in tumorigenesis. Taken together, these results suggest that AEG-1 may play a prominent role during normal mouse development in the context of cell proliferation as well as differentiation, and that temporal regulation of AEG-1 expression may be required during specific stages and in specific tissues during development.</P>
Je Hee Lee,Seon Young Choi,Yoon-Seong Jeon,Hye Ri Lee,김은진,Binh Minh Nguyen,Nguyen Tran Hien,M. Ansaruzzaman,M. Sirajul Islam,Nurul A. Bhuiyan,S.K. Niyogi,B.L. Sarkar,G. Balakrish Nair,Dae Shick Kim,An 한국미생물학회 2009 The journal of microbiology Vol.47 No.6
Analysis of the CTX prophage and RS1 element in hybrid and altered Vibrio cholera O1 strains showed two classifiable groups. Group I strains contain a tandem repeat of classical CTX prophage on the small chromosome. Strains in this group either contain no element(s) or an additional CTX prophage or RS1 element(s) on the large chromosome. Group II strains harbor RS1 and CTX prophage, which has an El Tor type rstR and classical ctxB on the large chromosome.