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RISS 인기검색어
- 검색키워드
- 저자 : Anping Chen (검색결과 4 건)
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Dou Zhifeng,Wang Nan,Chen Zhinan,Zheng Anping,Lu Falong,Lv Zhongbin 대한전기학회 2023 Journal of Electrical Engineering & Technology Vol.18 No.2
Conventional Finite Control Set Model Predictive Control (FCS-MPC) suffers from large neutral point voltage fluctuation, cumbersome calculation process, as well as high current Total Harmonic Distortions for 3-level T-type grid-tied inverter. An improved FCS-MPC method is proposed in this paper by directly calculating the switch state’s cost function. This method uses the 3-phase switching state Sx to represent the load current i, the DC side neutral point voltage offset ΔUc, the load current prediction value i(k + 1), and establishes a real-time cost function g through 27 switching vectors. In the loop calculation, the switching vector is selected by minimizing the absolute value of the cost function g, and the output switching state is represented by the switching vector. Thus, the inverter can be switched ON or OFF depending on the stat of the next moment. The FCS-MPC of a 3-level T-type grid-tied inverter is also established by simulation, and the effectiveness of the proposed method is verified by experimental results.
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Yali, Liang,Zhichao, Qiu,Yaohe, Li,Anping, Liu,Zhixiong, Chen,Huliwen, Huliwen,man, Luo,jing, He,Xiaoyang, Xiaoyang,Hai, Lan Techno-Press 2021 Advances in nano research Vol.10 No.6
Disseminated candidiasis (DC) arising from nosocomial fungal infection is a life-threatening complication in critically ill, nonneutropenic patients. The overall nosocomial fungal infection rate in United States hospitals doubled from 1980-1990. Until recently, amphotericin B was the only agent available for the treatment of life-threatening candidal infections, but its use is plagued by toxicities including nephrotoxicity and infusion-related reactions such as rigors and hypotension. The availability of fluconazole, which is regarded more much less toxic than amphotericin B, prompted a surge in research to determine if it is as efficacious in the management of candidemia and hematogenously disseminated candidiasis. Complicating the interpretation of studies is the broad range of infection severity, from candidemia that may be transient and self-limiting to life-threatening hematogenously disseminated candidiasis. This study has used the models of Artificial neural network (ANN) and Support Vector regression (SVR) to accurately assess the clinical trials comparing fluconazole and amphotericin B demonstrate the efficacy of fluconazole for catheter-associated candidemia in critically ill patients when the likely pathogen is Candida albicans. As a result, Amphotericin B should remain the first-line agent for the management of candidemia and hematogenously disseminated candidiasis in all other patients. Also, SVR could accurately assess the efficacy of fluconazole for catheter-associated candidemia in critically ill patients.
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Hu, Pei,Qiu, Zhichao,Li, Yaohe,Liu, Anping,Chen, Zhixiong,Huliwen, Huliwen,Luo, Man,Guxuekui, Guxuekui,Xiaoyang, Xiaoyang,Xie, Ying,Lan, Hai Techno-Press 2021 Advances in nano research Vol.11 No.2
Acute leukemia is a malignant tumor originating from the hematopoietic system with the highest incidence and mortality. At present, the main clinical treatment of leukemia is still chemotherapy, during the course of which the multidrug resistance (MDR) will significantly reduce remission rate and disease-free survival rate of patients. MDR is the most important factor affecting refractory/recurrent acute leukemia. Therefore, reversing leukemia MDR is one of the best ways to improve the complete remission rate of refractory/recurrent acute leukemia, and the study of drugs and methods to overcome leukemia MDR has received extensive attention in the leukemia research field. This study was to primarily investigate the effects of Liushen pills on leukemia drug-resistant cell line K562/DOX in inhibiting growth, reversing resistance and inducing apoptosis in anticipation of providing useful cytological and molecular biological basis for the treatment of refractory/recurrent acute leukemia. The serum containing toad venom was prepared by means of Chinese drug serum pharmacology. MTT assay was used to detect the inhibitory rates of human leukemia cell line K562/DOX after being treated with the serum containing toad venom as well as daunorubicin, or with the serum containing toad venom alone at different time points. Real-time fluorescent quantitative analysis (RT-PCR) was performed to determine the effects of serum containing toad venom on the expression of BCL-2 mRNA in human leukemia cell line K562/DOX. Compared to the control group, toad venom showed inhibitory effects on K562/DOX cells; the expression level of BCL-2 mRNA in toad venom group were decreased, indicating that toad venom may reverse the resistance of K562/DOX cells by down-regulating the expression level of MDR1.
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Junliang Ma,Yijun Luo,Yingjie Liu,Cheng Chen,Anping Chen,Lubiao Liang,Wenxiang Wang,Yongxiang Song 대한약리학회 2023 The Korean Journal of Physiology & Pharmacology Vol.27 No.1
Esophageal squamous cell carcinoma (ESCC) is a kind of malignant tumor with high incidence and mortality in the digestive system. The aim of this study is to explore the function of lnc-ABCA12-3 in the development of ESCC and its unique mechanisms. RT-PCR was applied to detect gene transcription levels in tissues or cell lines like TE-1, EC9706, and HEEC cells. Western blot was conducted to identify protein expression levels of mitochondrial apoptosis and toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) signaling pathway. CCK-8 and EdU assays were carried out to measure cell proliferation, and cell apoptosis was examined by flow cytometry. ELISA was used for checking the changes in glycolysis-related indicators. Lnc-ABCA12-3 was highly expressed in ESCC tissues and cells, which preferred it to be a candidate target. The TE-1 and EC9706 cells proliferation and glycolysis were obviously inhibited with the downregulation of lnc-ABCA12-3, while apoptosis was promoted. TLR4 activator could largely reverse the apoptosis acceleration and relieved the proliferation and glycolysis suppression caused by lnc-ABCA12-3 downregulation. Moreover, the effect of lnc-ABCA12-3 on ESCC cells was actualized by activating the TLR4/NF-κB signaling pathway under the mediation of exosome. Taken together, the lnc-ABCA12-3 could promote the proliferation and glycolysis of ESCC, while repressing its apoptosis probably by regulating the TLR4/NF-κB signaling pathway under the mediation of exosome.
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