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Die intestinale Mikrobiota: Das Faktotum im menschlichen Darm
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PWM 전압원 인버터의 새로운 스위칭 방법
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Bortezomib과 JSI-124 병합 처리된 종양항원 부가 수지상세포의 항종양 효과 = Combination of bortezomib and JSI-124 enhanced antitumor activity of cytotoxic T lymphocytes by necrotic tumor cells loaded dendritic cells
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Improving methods for normalizing biomedical text entities with concepts from an ontology with (almost) no training data at BLAH5 the CONTES
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가와사키병에서 나타난 급성 음낭증 1예
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공동체의 본질과 실현에 관한 연구
- 검색키워드
- 저자 : Lu Falong (검색결과 2 건)
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Chung, Young Gie,Matoba, Shogo,Liu, Yuting,Eum, Jin Hee,Lu, Falong,Jiang, Wei,Lee, Jeoung Eun,Sepilian, Vicken,Cha, Kwang Yul,Lee, Dong Ryul,Zhang, Yi Elsevier 2015 Cell stem cell Vol.17 No.6
<P><B>Summary</B></P> <P>The extremely low efficiency of human embryonic stem cell (hESC) derivation using somatic cell nuclear transfer (SCNT) limits its potential application. Blastocyst formation from human SCNT embryos occurs at a low rate and with only some oocyte donors. We previously showed in mice that reduction of histone H3 lysine 9 trimethylation (H3K9me3) through ectopic expression of the H3K9me3 demethylase Kdm4d greatly improves SCNT embryo development. Here we show that overexpression of a related H3K9me3 demethylase KDM4A improves human SCNT, and that, as in mice, H3K9me3 in the human somatic cell genome is an SCNT reprogramming barrier. Overexpression of KDM4A significantly improves the blastocyst formation rate in human SCNT embryos by facilitating transcriptional reprogramming, allowing efficient derivation of SCNT-derived ESCs using adult Age-related Macular Degeneration (AMD) patient somatic nuclei donors. This conserved mechanistic insight has potential applications for improving SCNT in a variety of contexts, including regenerative medicine.</P> <P><B>Highlights</B></P> <P> <UL> <LI> H3K9me3 is a barrier for human SCNT reprogramming as in mouse </LI> <LI> Injection of human KDM4A mRNA improves SCNT success in mouse oocytes </LI> <LI> KDM4A also improves human SCNT blastocyst formation and NT-ESC derivation </LI> <LI> H3K9me3 removal facilitates zygotic genome activation in human SCNT embryos </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Dou Zhifeng,Wang Nan,Chen Zhinan,Zheng Anping,Lu Falong,Lv Zhongbin 대한전기학회 2023 Journal of Electrical Engineering & Technology Vol.18 No.2
Conventional Finite Control Set Model Predictive Control (FCS-MPC) suffers from large neutral point voltage fluctuation, cumbersome calculation process, as well as high current Total Harmonic Distortions for 3-level T-type grid-tied inverter. An improved FCS-MPC method is proposed in this paper by directly calculating the switch state’s cost function. This method uses the 3-phase switching state Sx to represent the load current i, the DC side neutral point voltage offset ΔUc, the load current prediction value i(k + 1), and establishes a real-time cost function g through 27 switching vectors. In the loop calculation, the switching vector is selected by minimizing the absolute value of the cost function g, and the output switching state is represented by the switching vector. Thus, the inverter can be switched ON or OFF depending on the stat of the next moment. The FCS-MPC of a 3-level T-type grid-tied inverter is also established by simulation, and the effectiveness of the proposed method is verified by experimental results.
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