http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
류마티스 관절염 환자에서 MTHFR 유전자 다형성과 경동맥 죽상경화증과의 관계
박재홍 ( Jae Hong Park ),( Ahmed El Sohemy ),강태영 ( Tae Young Kang ),정청일 ( Chung Il Joung ),전석철 ( Seok Chol Jeon ),이혜순 ( Hye Soon Lee ),엄완식 ( Wan Sik Uhm ),김태환 ( Tae Hwan Kim ),전재범 ( Jae Bum Jun ),유대현 ( D 대한류마티스학회 2003 대한류마티스학회지 Vol.10 No.3
Objective: Studies have suggested that the 5, 10-methylenetetrahydrofolate reductase (MTHFR) C677T mutation (alanine→valine) is a risk factor for atherosclerotic disease. We assessed the association between MTHFR gene polymorphism and carotid atherosclerosis in patients with rheumatoid arthritis (RA). Methods: Forty postmenopausal RA women (mean age: 58±5 years, mean duration of RA 14±5 years) treated with low dose methotrexate, other concurrent disease modifying anti-rheumatic drugs, non-steroidal anti-inflammatory drugs, steroid (prednisolone ≤5 mg/day) and folic acid (≥1 mg/day) were studied. The genetic polymorphism was detected by the polymerase chain reaction. We measured intima-media thickness (IMT) and plaques of the common carotid arteries by ultrasonography, and evaluated relations among the known risk factors for atherosclerosis, the genetic polymorphism, RA outcomes (Steinbrocker`s radiological stage and functional class defined by the ACR criteria) and markers of inflammation (erythrocyte sedimentation rate and C-reactive protein). Results: Among the 40 subjects, 12 had MTHFR genotype CC, 24 genotype CT, and 4 genotype TT. The frequencies of the MTHFR C and T allele were 0.6 and 0.4, respectively. Between the subjects with the CC genotype and those with the mutant T allele, there was no difference in age, body mass index, blood pressure (BP), lipid, duration of RA, RA outcome indices, rheumatoid factor, acute phase reactants and IMT. Carotid IMT was positively associated with age, systolic BP and antihypertensive drug use. There was no significant association between carotid IMT and the MTHFR C677T mutation. Conclusion: It is assumed that there was no significant relationship between the MTHFR C677T polymorphism and carotid atherosclerosis in Korean postmenopausal RA women.
한국인 류마티스 관절염과 Catalase와 PPAR-γ유전자 다형성의 연관성
최찬범,김태환,전재범,유대현,배상철,Ahmed El-Sohemy,성상석,박용욱,이혜순,엄완식 대한류마티스학회 2004 대한류마티스학회지 Vol.11 No.3
Objective: To investigate the association between a single nucleotide polymorphism in the catalase and peroxisome proliferator activated receptor-γ (PPAR-γ) genes with risk and severity of rheumatoid arthritis (RA) in Korea. Methods: DNA was isolated from blood samples collected from 473 Korean patients with RA and 400 Korean controls. Genotyping for the C-262T polymorphism of catalase and the Pro12Ala polymorphism of PPAR-γ was performed by PCR-RFLP (restriction fragment length polymorphism) analysis. Subjects were classified according to ACR criteria for RA, KHAQ, and radiological severity classification by Steinbroker. Results: In patient group, catalase C/T and T/T polymorphism was seen in 23 (4.9%) and 0 patients while Pro/Ala and Ala/Ala PPAR-γ polymorphism was seen in 42 (8.9%) and 1 (0.2%) patients. In control group, catalase C/T and T/T polymorphism was seen in 25 (6.3%) and 1 (0.2%) controls while Pro/Ala and Ala/Ala PPAR-γ polymorphism was seen in 34 (8.5%) and 4 (1%) controls. Catalase and PPAR-γ polymorphism showed no association with the susceptibility to RA individually but, when combined association was found although it had no statistical significance, which was possibly due to its low frequency. Catalase and HLA-DRB1 polymorphism showed significant interaction on development of RA but, no interaction was found between PPAR-γ and HLA-DRB1. Catalase and PPAR-γ polymorphism showed no association with the severity or functional status of RA. Conclusion: Our results show that genetic polymorphisms of catalase and PPAR-γ has no association with the susceptibility to RA. Catalase and HLA-DRB1 polymorphism showed significant interaction on development of RA.
류마티스 관절염 환자에서 methotrexate 부작용과 methylenetetrahydrofolate reductase (MTHFR) 유전자 다형성의 상관관계
김성규 ( Seong Kyu Kim ),전재범 ( Jae Bum Jun ),박용욱 ( Yong Wook Park ),이혜순 ( Hye Soon Lee ),엄완식 ( Wan Sik Uhm ),김태환 ( Tae Hwan Kim ),유대현 ( Dae Hyun Yoo ),배상철 ( Sang Cheol Bae ),( Ahmed El Sohemy ) 대한내과학회 2004 대한내과학회지 Vol.67 No.2