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Adam Burr(Adam Burr ),Paul Harari(Paul Harari ),Aaron Wieland(Aaron Wieland ),Randall Kimple(Randall Kimple ),Gregory Hartig(Gregory Hartig ),Matthew Witek(Matthew Witek ) 대한방사선종양학회 2022 Radiation Oncology Journal Vol.40 No.4
Purpose: Optimal radiotherapy treatment volumes for patients with locally advanced hypopharynx squamous cell carcinoma should ensure maximal tumor coverage with minimal inclusion of normal surrounding structures. Here we evaluated the effectiveness of a direct 3-mm high-dose gross tumor volume to planning target volume expansion on clinical outcomes for hypopharynx cancers. Materials and Methods: We performed a retrospective analysis of patients with hypopharynx carcinoma treated between 2004 and 2018 with primary radiotherapy using a direct high-dose gross tumor volume to planning target volume expansion and with or without concurrent systemic therapy. Diagnostic imaging of recurrences was co-registered with the planning CT. Spatial and volumetric analyses of contoured recurrences were compared with planned isodose lines. Failures were initially defined as in field, marginal, elective nodal, and out of field. Each failure was further classified as central high-dose, peripheral high-dose, central intermediate/low-dose, peripheral intermediate/low-dose, and extraneous. Clinical outcomes were analyzed by Kaplan-Meier estimation. Results: Thirty-six patients were identified. At a median follow-up at 52.4 months, estimated 5-year overall survival was 59.3% (95% confidence interval [CI], 36.3%–74.1%), 5-year local and nodal control was 71.7% (95% CI, 47.1%–86.3%) and 69.9% (95% CI, 57.0%–82.6%), respectively. The most common failure was in the high-dose primary target volume. The gastrostomy tube retention rate at 1 year among patients without recurrence was 13.0% (95% CI, 3.2%–29.7%). Conclusion: Minimal high-dose target volume expansions for hypopharynx cancers were associated with favorable locoregional control. This approach may enable therapy intensification to improve clinical outcomes.
Cariprazine — an Alternative Treatment for Clozapine-resistant Schizophrenia?
Adam Montgomery(Adam Montgomery ),Marianna Rogowska(Marianna Rogowska ),Luiz Dratcu(Luiz Dratcu ) 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1
Treatment-resistant schizophrenia (TRS) poses a significant therapeutic challenge in psychiatric practice. Clozapine is recognized as a treatment of choice in TRS but is not always effective in alleviating patients’ symptoms. Additionally, clozapine therapy is associated with multiple side effects and monitoring requirements that often limit its use and negatively affect patients’ compliance with the treatment. Although clozapine augmentation options are available, there is currently no alternative monotherapy proven to be effective in TRS. We present a case of a young man with TRS who failed to respond to appropriate trials of risperidone, aripiprazole and also clozapine, and who experienced impairing adverse effects of clozapine that made further clozapine treatment not only futile but also detrimental to his health. He was successfully treated with cariprazine monotherapy, which culminated in the remission of his both positive and negative symptoms of psychosis as well as in the marked improvement in social functioning. Cariprazine, a newer atypical antipsychotic endowed with a D3-preferring mode of action, may offer a better tolerated and more acceptable treatment option for patients with difficult-to-treat psychotic symptoms.
Adam, J.,Adamová,, D.,Aggarwal, M.M.,Aglieri Rinella, G.,Agnello, M.,Agrawal, N.,Ahammed, Z.,Ahmad, S.,Ahn, S.U.,Aiola, S.,Akindinov, A.,Alam, S.N.,Albuquerque, D.S.D.,Aleksandrov, D.,Alessandro North-Holland Pub. Co 2017 Physics letters. Section B Vol.771 No.-
<P><B>Abstract</B></P> <P>Electrons from heavy-flavour hadron decays (charm and beauty) were measured with the ALICE detector in Pb–Pb collisions at a centre-of-mass of energy <SUB> s NN </SUB> = 2.76 TeV . The transverse momentum ( <SUB> p T </SUB> ) differential production yields at mid-rapidity were used to calculate the nuclear modification factor <SUB> R AA </SUB> in the interval 3 < <SUB> p T </SUB> < 18 GeV/<I>c</I>. The <SUB> R AA </SUB> shows a strong suppression compared to binary scaling of pp collisions at the same energy (up to a factor of 4) in the 10% most central Pb–Pb collisions. There is a centrality trend of suppression, and a weaker suppression (down to a factor of 2) in semi-peripheral (50–80%) collisions is observed. The suppression of electrons in this broad <SUB> p T </SUB> interval indicates that both charm and beauty quarks lose energy when they traverse the hot medium formed in Pb–Pb collisions at LHC.</P>
Novel bilateral bifurcation of the coronary vasculature
Adam Michael Taylor,Joe McAleer,Quenton Wessels 대한해부학회 2021 Anatomy & Cell Biology Vol.54 No.1
Multiple variants and anomalies in the coronary vasculature have been reported. Some variants, particularly those with duplication, can be advantageous, many are insignificant and some are ultimately lethal. Many of these variants and anomalies are not identified until imaged or post-mortem. A novel bilateral bifid variation of the coronary arteries was observed in 49-year-old male cadaver. The respective origins were associated with the left and right aortic cusps from single ostia. Immediate bifurcation followed on either side. A right sided accessory branch supplied the pulmonary trunk and right ventricle. A more standard branch continued to form the posterior interventricular artery. The left sided variation demonstrated a solitary circumflex artery (towards the posterior interventricular septum) and, left marginal and anterior interventricular branches shortly after bifurcation. This case may be beneficial in surviving adverse cardiac events, particularly those associated with lifestyle. They also present a ‘double’ challenge for clinicians.
Expatriation, Snobbery, and Uncommon Commonness in Aaron’s Rod and Kangaroo
( Adam Parkes ) 한국로렌스학회 2018 D.H. 로렌스 연구 Vol.26 No.2
This essay reads two of Lawrence’s post-war novels, Aaron’s Rod (1922) and Kangaroo (1923) as an expatriate’s books about expatriation, by considering their contrasting approaches to relations between narrative, time, and place. It is divided into two parts. Part 1 considers how Aaron’s Rod enacts a drama of travel and expatriation in a semi-picaresque narrative structure that plays movement across national borders against movement within those borders. The novel’s complex structure―coupled with its close attention to cultural geographies―also allows Lawrence to articulate persistent anxieties about snobbery and the commonplace that inform the novel’s sense of what might count as truly aristocratic. Ultimately, those anxieties are expressed not only in the novel’s content and narrative structure but even in its language. Part 2 shows how Lawrence extends his confrontation with these formal and thematic problems in Kangaroo. This book renews and heightens the pressure on Lawrence’s ideas about the aristocratic and the common, by reframing them in the context of a burgeoning ideological war between fascism and socialism. The narrative form and language of Kangaroo generate resistance to the standard terms―democracy vs. aristocracy, socialism vs. communism, nationalism vs. internationalism―in which public debates about the postwar world were typically conducted. By its verbal magic, especially by its use of simile as the figurative embodiment of a principle of perpetual migration, this novel also conjures a new vision of the living universe, slipping the noose (if only for a time) of self, or culture, or society.
Numerical analysis of Brazilian split test on concrete cylinder
Adam Wosatko,Andrzej Winnicki,Jerzy Pamin 사단법인 한국계산역학회 2011 Computers and Concrete, An International Journal Vol.8 No.3
The paper presents simulations of the Brazilian test using two numerical models. Both models are regularized in order to obtain results independent of discretization. The first one, called gradient damage, is refined by additional averaging equation which contains gradient terms and an internal length scale as localization limiter. In the second one, called viscoplastic consistency model, the yield function depends on the viscoplastic strain rate. In this model regularization properties are governed by the assumed strain rate. The two models are implemented in the FEAP finite element package and compared in this paper. Parameter studies of the split test are performed in order to point out the features of each model.
Correlation measurements between flow harmonics in Au+Au collisions at RHIC
Adam, J.,Adamczyk, L.,Adams, J.R.,Adkins, J.K.,Agakishiev, G.,Aggarwal, M.M.,Ahammed, Z.,Ajitanand, N.N.,Alekseev, I.,Anderson, D.M.,Aoyama, R.,Aparin, A.,Arkhipkin, D.,Aschenauer, E.C.,Ashraf, M.U.,A North-Holland Pub. Co 2018 Physics letters. Section B Vol.783 No.-
<P><B>Abstract</B></P> <P>Flow harmonics ( <SUB> v n </SUB> ) in the Fourier expansion of the azimuthal distribution of particles are widely used to quantify the anisotropy in particle emission in high-energy heavy-ion collisions. The symmetric cumulants, S C ( m , n ) , are used to measure the correlations between different orders of flow harmonics. These correlations are used to constrain the initial conditions and the transport properties of the medium in theoretical models. In this Letter, we present the first measurements of the four-particle symmetric cumulants in Au+Au collisions at <SUB> s N N </SUB> = 39 and 200 GeV from data collected by the STAR experiment at RHIC. We observe that <SUB> v 2 </SUB> and <SUB> v 3 </SUB> are anti-correlated in all centrality intervals with similar correlation strengths from 39 GeV Au+Au to 2.76 TeV Pb+Pb (measured by the ALICE experiment). The <SUB> v 2 </SUB> – <SUB> v 4 </SUB> correlation seems to be stronger at 39 GeV than at higher collision energies. The initial-stage anti-correlations between second and third order eccentricities are sufficient to describe the measured correlations between <SUB> v 2 </SUB> and <SUB> v 3 </SUB> . The best description of <SUB> v 2 </SUB> – <SUB> v 4 </SUB> correlations at <SUB> s N N </SUB> = 200 GeV is obtained with inclusion of the system's nonlinear response to initial eccentricities accompanied by the viscous effect with η / s > 0.08 . Theoretical calculations using different initial conditions, equations of state and viscous coefficients need to be further explored to extract η / s of the medium created at RHIC.</P>
Measurement of jet suppression in central Pb–Pb collisions at <sub> s NN </sub> = 2.76 TeV
Adam, J.,Adamová,, D.,Aggarwal, M.M.,Aglieri Rinella, G.,Agnello, M.,Agrawal, N.,Ahammed, Z.,Ahmed, I.,Ahn, S.U.,Aimo, I.,Aiola, S.,Ajaz, M.,Akindinov, A.,Alam, S.N.,Aleksandrov, D.,Alessandro, North-Holland Pub. Co 2015 Physics letters. Section B Vol.746 No.-
<P><B>Abstract</B></P> <P>The transverse momentum ( <SUB> p T </SUB> ) spectrum and nuclear modification factor ( <SUB> R AA </SUB> ) of reconstructed jets in 0–10% and 10–30% central Pb–Pb collisions at <SUB> s NN </SUB> = 2.76 TeV were measured. Jets were reconstructed using the anti- <SUB> k T </SUB> jet algorithm with a resolution parameter of R = 0.2 from charged and neutral particles, utilizing the ALICE tracking detectors and Electromagnetic Calorimeter (EMCal). The jet <SUB> p T </SUB> spectra are reported in the pseudorapidity interval of | <SUB> η jet </SUB> | < 0.5 for 40 < <SUB> p T , jet </SUB> < 120 GeV / c in 0–10% and for 30 < <SUB> p T , jet </SUB> < 100 GeV / c in 10–30% collisions. Reconstructed jets were required to contain a leading charged particle with <SUB> p T </SUB> > 5 GeV / c to suppress jets constructed from the combinatorial background in Pb–Pb collisions. The leading charged particle requirement applied to jet spectra both in pp and Pb–Pb collisions had a negligible effect on the <SUB> R AA </SUB> . The nuclear modification factor <SUB> R AA </SUB> was found to be 0.28 ± 0.04 in 0–10% and 0.35 ± 0.04 in 10–30% collisions, independent of <SUB> p T , jet </SUB> within the uncertainties of the measurement. The observed suppression is in fair agreement with expectations from two model calculations with different approaches to jet quenching.</P>