Development of Wetland Conservation Policy: Wetland Mitigation Bank

Sang Weon Bang,Sun Young Ahn,Ju Hyeon Park 한국환경정책평가연구원 2006 기본연구보고서 Vol.2006 No.-

Fingerprinting Analysis of Fresh Ginseng Roots of Different Ages Using $^1H-NMR$ Spectroscopy and Principal Components Analysis

Shin, Yoo-Soo,Bang, Kyong-Hwan,In, Dong-Soo,Kim, Ok-Tae,Hyun, Dong-Yoon,Ahn, In-Ok,Ku, Bon-Cho,Kim, Suk-Weon,Seong, Nak-Sul,Cha, Seon-Woo,Lee, Dong-Ho,Choi, Hyung-Kyoon 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.12

Fingerprinting analysis of fresh ginseng according to root age was performed using $^1H-NMR$ spectroscopy and multivariate analysis techniques. Various peaks were detected in the aliphatic (0-3 ppm), sugar (3-6 ppm), and aromatic (6-9 ppm) regions of the $^1H-NMR$ spectra of the water extracts of fresh ginseng root. The use of principal components (PCs) analysis (PCA) for metabolomic profiling allowed the large $^1H-NMR$ data set obtained for various metabolites to be reduced to PC1, PC2, and PC3. Two dimensional score plots showed clear separations with these three components at different roots ages, and explained 89.6% of the total variance. Canonical discriminant analysis identified the ginseng roots at various ages from the NMR results with over 89.9% discrimination accuracy. These results indicate that the combination of $^1H-NMR$ and PCA provides a very promising tool for the authentication and quality control of fresh ginseng roots at different ages.

마늘 및 생강추출물의 DNA 손상억제작용

강진훈(Jin-Hoon Kang),안방원(Bang-Weon Ahn),이동호(Dong-Ho Lee),변한석(Han-Seok Byun),김선봉(Seon-Bong Kim),박영호(Yeung-Ho Park) 한국식품과학회 1988 한국식품과학회지 Vol.20 No.3

천연식품성분에 의한 발암성 니트로사민생성인자 분해작용 l. 야채유출물의 아질산염 분해작용

김동수,안방원,염동민,이동호,김선봉,박영호,KIM Dong-Soo,AHN Bang-Weon,YEUM Dong-Min,LEE Dong-Ho,KIM Seon-Bong,PARK Yeung-Ho 한국수산과학회 1987 한국수산과학회지 Vol.20 No.5

The present paper was investigated to elucidate the nitrite-scavenging ability of vegetable extracts. Vegetable extracts possessed the scavenging ability of nitrite. By fractionatioh of vegetable extracts,nitrite-scavenging ability of garlic (Allitum sativum for. Pekinense), chinese pepper (Zanthexylum schinifolium), onion (Allium cepa), welsh onion (Allium fistulosum) and ginger (Zingiber officinale) extracts were effective in the water-soluble fraction, but carrot (Daucus carota uar. sativa) in the methanol-soluble fraction. Nitrite-scavenging ability of vegetable extracts was also pH-dependent, highest at pH 1.2 and lowest at pH 6.0. Particularly, nitrite-scavenging abilities of water-soluble fractions obtained from garlic and chinese pepper were similar to that of L-ascorbic acid at pH 1.2. After vegetable extracts were treated with sodium borohydride, nitrite-scavenging ability was remarkably decreased at pH 1.2. It is assumed that reducing powers of vegetable extracts participated in their nitritescavenging abilities. 일상 식생활에서 널리 섭취하고 있는 야채류를 사용하여 니트로사민의 직접적인 생성인자인 아질산염 분해작용에 관하여 검토하였는데, 그 결과를 요약하면 다음과 같다. 1. 마늘, 산초, 생강, 양파 및 파 둥은 수용성획분에서 당근은 methanol 가용성획분에서 각각 아질산염 분핵능이 높게 나타났다. 2. 반응용액의 pH변화에 따른 아질산염 분해능은 pH 1.2에서 가장 컸으며, pH가 증가할수록 분해능은 감소하였다. 3. 각 시료를 10mg씩 취하여 얻은 아질산염 분해능을 동량의 L-ascorbic acid와 비교한 경우, 마늘과 산초가 수용성획분에서 L-ascorbic acid와 거의 비슷한 분해능을 나타내었다. 4. 각 시료를 $NaBH_4$로 처리하여 환원능을 소실시킨 후에 측정한 아질산염 분해능은 pH 1.2에서 시료 모두 모두 그 값이 현저하게 감소하였다

천연식품성분에 의한 의한 발암성 니트로사민생성인자 분해작용 2. 해조유출물의 아질산염 분해작용

김선봉,안장원,염동민,이동호,박영호,김동수,KIM Seon-Bong,AHN Bang-Weon,YEUM Dong-Min,LEE Dong-Ho,PARK Yeung-Ho,KIM Dong-Soo 한국수산과학회 1987 한국수산과학회지 Vol.20 No.5

The present paper was investigated to elucidate the nitrite-scavenging ability of seaweed extracts. Seaweed extracts possessed the scavenging ability of nitrite. By fractionation of seaweed extracts, nitrite-scavenging ability of laver(Porphyra tenera), sea lettuce(Enteromorpha compresa) extracts were effective in the water-soluble fraction, but sea mustard (Undaria pinnatifida), sea staghorn (Codium fragile) extracts in the methanol-soluble fraction. Nitrite scavenging ability of seaweed extracts was also pH-dependent, highest at pH1.2 and lowest at pH6.0. Particularly, nitrite-scavenging abilities of water-soluble fractions obtained from laver and sea lettuce were similar to that of L-ascorbic acid at pHl.2. After seaweed extracts were treated with sodium borohydride, nitrite-scavenging ability was remarkably decreased at pH1.2. It is assumed that reducing powers of seaweed extracts participated in their nitrite-scavenging abilities. 일상 식생활에서 널리 섭취하고 있는 해조류를 사용하여 니트로사민의 직접적인 생성인자인 아질산염 분해작용에 관하여 검토하였는데, 그 결과를 요약하면 다음과 같다. 1. 본 실험에 사용한 시료들의 아질산염 분해능은 김${\cdot}$파래 등은 수용성획분과 methanol 가용성획분에서, 미역${\cdot}$청각 등은 methanol 가용성획분에서 그 분해능이 높게 나타났다. 2. 반응용액의 pH 변화에 따른 아질산염 분해능은 pH 1.2에서 가장 컸으며, pH가 증가할수록 분해능은 감소하였다. 3. 각 시료를 10mg씩 취하여 얻은 아질산염 분해능은 동량의 L-ascorbic acid와 비교한 경우, 김과 파래는 pH 1.2에서 L-ascorbic acid와 거의 비슷한 분해능을 나타내었다. 4. 각 시료를 $NaBH_4$로 처리하여 환원능을 소실시킨 후에 측정한 아질산염 분해능은 pH 1.2에서 시료 모두 그 값이 현저하게 감소하였다.

천연식품성분에 의한 발암성 니트로사민의 생성억제작용

이동호,박영호,강진훈,김선봉,안방원,도정룡,여생규 한국수산학회 1993 한국수산과학회지 Vol.26 No.4

천연식품성분에 의한 발암성 니트로사민의 생성 억제작용을 밝히기 위하여 야채류 중에서는 고추, 마늘, 파, 산초, 양차, 생강 및 당근을, 해조류 중에서는 김, 파래, 미역 및 정각 등을 시료로 하여 발암성 니트로사민의 하나인 N-nitrosodimethylamine(NDMA)의 생성억제작용에 관하여 연구·검토하였는데, 그 결과를 요약하면 다음과 같다. 1. 본 실험에 사용한 야채 및 해조추출물들은 모두 니트로사민 생성억제작용이 있었으며, 그 중에서도 야채류 중에서는 마늘, 생강, 파 등이 pH 1.2에서 30∼40%, 당근이 10%로 나타났고, 해조류 중에서는 길과 파래 등이 40∼50%, 미역과 청각 등이 25% 정도의 니트로사민 생성억제작용을 나타내어, 해조류가 야채류에 비하여 억제효과가 좋았다. 또한, 야채 및 해조추출물의 첨가량이 증가함에 따라 니트로사민 생성억제효과도 증가하였다. 2. 반응용액의 pH변화에 따른 야채 및 해조추출물의 니트로사민 생성억제작용을 살펴본 결과, pH 6.0에서 가장 높은 억제효과를 보였고, pH 1.2와 pH 4.2에서는 서로 비슷한 억제효과를 나타내었다 NDMA의 생성억제절대량은 pH 1.2에서 가장 많았다. 3. 야채 및 해조추출물들을 30㎎씩 취하여 동량의 ascorbic acid아 니트로사민 생성억제효과를 비교해 본 결과, 야채추출물들 중 마늘, 파 및 생강은 pH 1.2에서 ascorbic acid와 거의 동등한 효과를 나타내었고 해조류중 김과 파래는 오히려 ascorbic acid보다 높게 나타났다. 4. 야채 및 해조추출물들을 80℃에서 10분간 가열처리한 후 니트로사민 생성억제효과를 가열 전과 비교해 본 결과, 가열 전후에 있어서 뚜렷한 유의차를 볼 수 없었다. 5. 야채 및 해조추출물들은 NaBH₄ 처리로 니트로사민 생성억제작용이 감소하였다. The present paper was investigated in the inhibitory action of vegetable and seaweed water-soluble extracts on the formation of carcinogenic N-nitrosodimethylamine(NDMA). The vegetable and seaweed extracts obtained from garlic(Allium sativum), onion(Allium cepa), green onion(Allium fistuiosum), Chinese pepper(Fagara mandshurica), green pepper (Capsicum annuum), red pepper(Capsicum annuum), ginger(Zingiber officinale), carrot (Daucus carota), laver(Porphyra tenera), sea lettuce(Entero compresa), sea mustard (Undaria pinnatifida) and sea staghorn(Codium fragile) were incubated with sodium nitrite-dimethylamine mixtures at 37℃ under different pH conditions. The formation of NDMA was reduced to 10∼40% and 25∼50% by the addition of vegetable and seaweed extracts 30㎎ at pH 1.2, respectively. The inhibition degree by the extracts at pH 1.2 was similiar to that at pH 4.2 and to that by ascorbic acid at pH 1.2. The inhibitory action of the extracts against NDMA formation was not decreased by heat treatment at 80℃ for 10min, but decreased by the treatment of sodium borohydride. It is assumed that reducing powers of the extracts participated in their inhibitory actions.

훈방대상 비행청소년의 분노, 분노대처 및 스트레스 반응

박상군(Sang-Kun Park),이후경(Hoo-Kyeong Lee),윤성철(Sung-Chul Yoon),안현주(Hyun-Joo Ahn),김선재(Sun-Jae Kim),방양원(Yang-Weon Bang),장혜진(Hye-Jin Jang) 대한소아청소년정신의학회 2005 소아청소년정신의학 Vol.16 No.2

Association between the 5-HTTLPR Genotype and Childhood Characteristics in Mood Disorders

Tae Kyung Eun,Seong Hoon Jeong,Kyu Young Lee,Se Hyun Kim,Yong Min Ahn,Yang Weon Bang,Eun-Jeong Joo 대한정신약물학회 2016 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.14 No.1

Objective: The features of childhood attention deficit hyperactivity disorder (ADHD) are significantly associated with adult mood disorders. Some genetic factors may be common to both ADHD and mood disorders underlie the association between these two phenotypes. The present study aimed to determine whether a genetic role may be played by the serotonin transporter-linked polymorphic region (5-HTTLPR) in the childhood ADHD features of adult patients with mood disorders. Methods: The present study included 232 patients with major depressive disorder (MDD), 154 patients with bipolar disorder (BPD), and 1,288 normal controls. Childhood ADHD features were assessed with the Korean version of the Wender Utah Rating Scale (WURS-K). The total score and the scores of three factors (impulsivity, inattention, and mood instability) from the WURS-K were analyzed to determine whether they were associated with the 5-HTTLPR genotype. Results: In the BPD type II group, the 5-HTTLPR genotype was significantly associated with the total score ( p =0.029) and the impulsivity factor ( p =0.004) on the WURS-K. However, the inattention and mood instability factors were not associated with the 5-HTTLPR genotype. BPD type I, MDD and normal control groups did not exhibit any significant associations between the WURS-K scores and the 5-HTTLPR genotype. Conclusion: The findings suggest that the 5-HTTLPR genotype may play a role in the impulsivity component of childhood ADHD in patients with BPD type II. Because of a small sample size and a single candidate gene, further studies investigating other candidate genes using a larger sample are warranted to determine any common genetic links.

Predictive Factors for the Mortality of Cardiovascular Patients at Coronary Care Unit

Eun Suk Shin,Myung Ho Jeong,Sang Chun Lim,Myung Ja Choi,Seon Young Jeong,Gill Yup Kim,Eun Jeong Lee,Su Mi Bang,Hyo Ran Lee,Young Joon Hong,Hyung Wook Park,Ju Han Kim,Weon Kim,Young Keun Ahn,Jeong Gwan Korean Society of Critical Care Medicine 2004 Acute and Critical Care Vol.19 No.1

BACKGROUND: Recently the incidence of coronary artery disease has been increased rapidly in Korea. After the introduction of coronary care unit, the mortality rate of cardiovascular patients has been decreased. The predictive factors for mortality in patients admitted at Coronary Care Unit (CCU) are important in the management of acutely ill cardiovascular patients. METHODS: One thousand one hundred and thirty patients (64.8+/-14.5 years), who were admitted at CCU from January 2002 to June 2003, were analyzed. The patients were divided into two groups according to mortality: the survived group (Group I: n=1055, 63.3+/-13.3 years) and the moribund group (Group II: n=75, 64.8+/-14.1 years). Clinical characteristics, risk factors, clinical diagnosis, laboratory, echocardiographic and coronary angiographic findings were compared between the two groups. RESULTS: The overall mortality at CCU was 6.6%, 75 out of 1130 patients. Age and sex were not different between both groups. Coronary artery disease was the most common cause of admission (886 out of 1130 patients) and death (46 out of 75 patients). Coronary angiographic findings were not different between the two groups. Left ventricular ejection fraction (LVEF) by echocardiogram was higher in Group I than in Group II (53.1+/-15.6% vs. 42.3+/-16.3%, p