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      • KCI등재후보

        뇌하수체 미세선종에 의한 쿠싱병의 접형골경유 수술의 치료성적

        이윤용(Yun Yong Lee),김진성(Jin Seong Kim),문병술(Byeong Sul Mun),신찬수(Chan Soo Shin),김성연(Seong Yeon Kim),조보연(Bo Youn Cho),이홍규(Hong Kyu Lee),고창순(Chang Soon Koh),정희원(Hee Won Joeng),한대희(Dae Hee Han),한문희(Moom Hee 대한내과학회 1997 대한내과학회지 Vol.53 No.6

        N/A Background: Cushing's disease is a hypercortisolic state attributable to hypersecretion of ACTH at pituitary gland Most of these diseases are due to pituitary microadenoma. Selective removal of adenoma by transsphenoidal microsurgery is the treatment of choice for Cushing's disease. We evaluated 25 cases to analyze results of transsphenoidal microsurgery and to identify prognostic factors that may predict successful outcome. Methods: From 1989 to 1995, 25 patients were diagnosed as having Cushing's disease in Seoul National University Hospital. They were underwent pituitary microsurgery and confirmed to have pituitary microadenoma radiologically and pathologically. About these patients. retrospective evaluation was done. Results: The patients consist of 21 females and 4 males and the age was ranged from 23 to 49 years. 19 patients (76%) were judged as immediate remission. The preoperative clinical, hormonal, and radiological characteristics of the remission and failure groups were similiar The patients who were immediate remission were followed from 3 months to 72 months. 3 patients had recurrences(15.8%) at 4, 8, 49 months after operation. The pre and postoperative clinical, hormonal, and radiological characteristics of the long-term remission and recurrence groups were similiar. We could not find any predictable factors of surgical outcome. Conclusion: The first line trearment of Cushing's disease is transsphenoidal microsurgery. However considering relative late and high rate of recurrence of Cushing's disease following curative surgery, careful longterm follow up is mandatory.

      • KCI등재

        보문 : 분리기술·열역학·멤브레인기술·초임계기술·이은용액 ; 활성탄을 이용한 산업체 악취물질의 열적 흡탈착 연구

        김주연 ( Joo Yeon Kim ),이영우 ( Young Woo Rhee ),한문희 ( Mun Hee Han ) 한국화학공학회 2012 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.50 No.3

        활성탄을 이용한 산업체 악취물질 제거 특성을 규명하기 위하여 일반적으로 사용되는 상업용 활성탄의 탈착반응 특성을 조사하였다. 활성탄의 물리·화학적 특성을 조사하기 위해 BET 비표면적을 분석하였으며, 활성탄의 흡착력을 평 가하기 위해 요오드가를 측정하였다. 활성탄에 흡착된 악취물질의 탈착반응특성 평가를 위해 열중량분석기 (Thermogravimetric Analyzer; TGA)를 사용하였다. 활성탄의 흡·탈착에 따른 반응특성을 알아보기 위해 Friedman 법 과 Freeman-Carroll 법을 이용하여 활성화에너지와 반응차수를 계산하였다. 활성탄은 신탄일 때 보다 재생탄일 때 흡착능력이 현저히 떨어졌으며, Friedman 법을 이용하여 활성화 에너지를 계산한 결과 15.9~23.4 kJ/mol, Freeman-Carroll 법을 이용하여 계산한 결과 22.7~33.8 kJ/mol로 나타났다. Desorption reaction characteristics of the commercial activated carbons which were used for the removal of industrial odorants were investigated. BET specific surface area was analyzed to investigate the chemicophysical property of activated carbon. Adsorptivity of activated carbon was estimated by iodine number. Thermogravimetric analyzer (TGA) was used to investigate the desorption characteristics. Activation energies and reaction orders for reaction characteristics according to adsorption and desorption of activated carbons were estimated by employing the Friedman method and Freeman-Carroll method. Adsorptivity of reprocessed activated carbons were significantly lower than that of fresh activated carbons. In this study, it was found that the activation energies were 15.9~23.4 kJ/mol in Friedman method and 22.7~33.8 kJ/mol in Freeman-Carroll method.

      • MDS-Spiral Coil을 이용한 뇌 동맥류의 경혈관적 치료

        정은철,최혜영,서대철,한문희 梨花女子大學校 醫科大學 醫科學硏究所 1995 EMJ (Ewha medical journal) Vol.18 No.4

        수술적 치료가 적용되지 않았거나 수술적 접근이 어려웠던 2례의 동맥류환자에서 MDS coil을 이용하여 경헐관적 색전을 시행하였다. 후하소동맥의 동맥류의 경우는 4×80mm coil 한개를 색전한 후 후하소뇌동맥의 혈류가 일시적으로 감소하였으나 추적검사상 이상소견없이 완전한 색전을 보였다. 후교통동맥류의 예에서는 5×80mm coil세개를 성공적으로 삽입하고 3×8mm coil을 추가로 삽입하였을 때 coil의 일부가 동맥류의 경부에서 내경동맥으로 빠져 나왔다. Curved microsnare catheter를 이용하여 일부를 제거하고 일부는 동맥류와 내경동맥에 걸쳐있었다. 색전직후의 동맥조영검사상 동맥류는 성공적으로 색전되었으며 동맥조영검사상 내경동백을 폐색하지 않으므로 시술을 중지하였다. 뇌의 동맥류환자에서 수술이 불가능하거나 수술적 접근이 어려운 경우, 수술후 동맥류가 재발한 경우 또는 파열되지 않은 동맥류 등에서 MDS coil을 이용한 경혈관적색전술은 시술을 대치할 수 있는 유용한 치료법이다. 0bjectives : To report e experience of performing embolization procedure of aneurysms with mechanical detachable coils(MDC). Methods : Two patients underwent embolization of eneurysms with mechanical detachable coils. One patient who had an aneurysm in the left posterior inferior cereberllar artery(PICA) underwent the embolization procedure with one spiral coil(4mm×80mm) and another patient who had an aneurysm in the left posterior(P-comm.) communicating artery aneurysm underwent the embolization procedure with four spiral coils(three 5mm×8mm and one 3mm×80mm). Results : Immediately after coil placement in the PICA the flow of contrast in the PICA reduced significantly. It may resulted from compression of the origin of PICA by the coil-packed aneurysm. The posttreatment course was not uneventful In case of P-comm. aneursym, the last coil(3mm×80mm) which embolized in the aneurysm, escaped from the aneurysm into the left internal carotid artery. Thej retrieval of the coil in the internal carotid artery with 3F microretrieval cathter was sucesfully performed. Conclusion : This preliminary experience suggests that the embolization procedure with mechanical detachable coils is a usful modality of treatment of cerebral aneurysm in case ofinoperable cases.

      • SCOPUSSCIEKCI등재

        뇌동정맥기형의 치료에 있어서 색전술의 역할 : Experience of 15 Cases

        이상형,김봉수,심기범,성정남,박인성,한문희,한대희 대한신경외과학회 1993 Journal of Korean neurosurgical society Vol.22 No.2

        The authors report the results of treatment in 15 patients with intracranial arteriovenous malformations(AVM's) who underwent embolization with n-butyl cyanoacrylate(NBCA) and poly vinyl alcohol(PVA) particle between March. 1990 and August. 1992 at Seoul National University Hospital and discuss about role of endovascular treatment in the management of intracranial AVM' s. Seven patients(46.7%) had pre-operative embolization, microsurgery was done in six patients and radiosurgery was done in one patient In patients with pre-operative embolization. endovascular treatment had helped microsurgery in dissection, diminution of blood transfusion, and shorter time of surgery. AVM's of two patients(l2.5%) were totally occluded by embolization alone. But they had morbidity after embolization due to inadvertent occlusion. AVM's of six patied40 % were partially occluded and recurrence of previous symptoms bleeding revascularization, increase of AVM nidus developed during follow up. It is concluded that role of endovascular treatment is in tracranial AVM's ajuvant. definite, palliative. Except surgical resection after embolization, embolization alone should be done very cautiously in definite and palliative treatment.

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