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EYEMAX free RGP 콘택트렌즈의 임상성능에 대한 유용성 평가
유근창,서정성 대한시과학회 2010 대한시과학회지 Vol.12 No.1
목적: 본 연구는 안정피로 개선용 EYEMAX free(Happy vision, Korea) RGP 렌즈에 대한 원거리 및 근거리 시력보정효과, 렌즈착용 후 증상, 안정피로에 대한 피험자의 만족도 등의 임상성능에 대한 유용성을 평가하고자 하였다. 방법: 18세~43세 남·여 35(70안)명을 대상으로 EYEMAX free RGP 렌즈를 착용 한 달 후 근거리시력과 원거리시력, 렌즈착용 증상, 렌즈 적응도, 안정피로 개선효과에 대하여 조사하였다. 결과: 피검사자의 원거리 및 근거리 안경교정시력이 각각 0.97±0.08D, 1.04±0.19D이었으나, 렌즈 착용 한 달 후 원거리 및 근거리 교정시력은 각각 1.19±0.16D, 1.30±0.13D로 안경교정시력 보다 높게 나타났다. 렌즈착용 1개월 후 자각증상의 빈도가 높은 증상은 건조감과 이물감이었으며, 피험자의 렌즈 적응도는 쉬운 적응이 23명, 보통의 적응이 9명이었으며, 3명만 적응이 어렵다고 하였다. 렌즈착용에 대한 6개 항목 만족도의 유효성 평가에서 평가점수가 0~2점의 피험자 수의 백분율이 66.7% 이상으로 유효성이 있는 것으로 나타났다. 결론: 전체 피험자 수에 대한 유효성 평가에서 EYEMAX free RGP 렌즈는 교정 후 원거리 및 근거리 시력보정 효과에 대한 피험자 수의 백분율이 97.2%로 나타나 시력교정에 대한 유효성이 있으며, 안정피로 개선에 대한 만족도가 높은 기능성 RGP 렌즈라고 생각된다. Purpose: To analyze clinical performance of Auto ref-Keratometer(ARK-510A: NIDEK Co.) and Corneal Analyzer (OPD-SCANⅡ: NIDEK Co.). Method: 33 subjects(mean age of 27.42±3.3) who have no ocular disease were recruited. Automatic refraction(ARK-510A: NIDEK Co.), OPD-SCAN Ⅱ: NIDEK Co.) and subjective refraction were measured twice with one day interval at the least. The values were converted to J vector(M, J0, J45) in order to evaluate reliability and accuracy. Result: Mean difference and 95% limit of agreement of test-retest by ARK-510A were M=-0.027±0.405D(-0.821~0.767D), J0=0.020±0.138D(-0.250~0.290D), J45=-0.002±0.097D(-0.192~ 0.188D) and M=0.094±0.495D(-0.876~1.064D), J0=0.026±0.138D(-0.244~0.300D), J45=0.002±0.093D(-0.180~0.184D) by OPD-SCANⅡ respectively. Reliability coefficient of ARK-510A was M=0.992, J0=0.976, J45=0.932, and that of OPD-SCANⅡ was M=0.989, J0=0.967, J45=0.903. Mean difference and 95% limit of agreement between measurements of subjective refraction and ARK-510A was M=0.258±0.600D(-0.918~1.434D), J0=-0.088±0.116D(-0.315~0.139D), J45=-0.009±0.120 (-0.244~0.226D) and those between subjective refraction and OPD-SCANⅡ was M=0.381±0.624D(-0.842~1.604D), J0=0.022±0.098D(-0.170~0.214D), J45=0.001±0.108D(-0.210~0.212D). Accuracy of two instrument was different at M(p=0.006) and J0(p=0.000) significantly. Conclusion: Automatic refractometer (ARK-510A) was showed better accuracy and repeatability than those of corneal analyzer(OPD-SCANⅡ). It is considered that corneal analyser can be used clinically to measure refractive error.
Maillard 반응모델로 부터 얻은 Maillard reaction products의 항산화 효과
유근창,최영록,김미현,김태희,주진우 강원대학교 동물생명과학연구소(구 강원대학교 동물자원공동연구소) 2007 동물자원연구 Vol.18 No.-
The objective of current study is to determine antioxidant activities of Maillard reaction products (MRPs) obtained from Maillard reaction model systems with different combinations of 15 individual amino acids and 3 different sugars(glucose, fructose and lactose). Antioxidant activities of MRPs were determined using techniques of measuring DPPH and ABTS-radical scavenging activities. The results indicated that radical scavenging activities of MRPs were significantly increased compared to individually thermal treated amino acids and sugars. Among the model systems, the systems containing glycine or lysine + sugars (glucose, fructose and fructose) displayed the stronger DPPH and ABTS radical scavenging activities than other model systems. In addition, when the thermal treatment time was increased, radical scavenging activities of MRPs were increased in a reaction time-dependent manner. Further investigation using bioassay-directed fractionation was performed using two model systems (glycine+glucose, lysine+glucose) which displayed the strongest radical scavenging activities. The reaction solution were subjected to partition with a different polarity of solvent (hexane, ethyl acetate, n-butanol, and water) for evaluation of their radical scavenging activity. Among them, ethyl acetate fraction exhibited the strongest DPPH-radical scavenging activity in both model systems.
Antioxidant Activity of Dopamine-Modified Hydrogels Containing Cross-linked Hyaluronic Acid
유근창,황정희,이철우 대한시과학회 2018 대한시과학회지 Vol.20 No.4
Purpose : : In this study, we made dopamine-functionalized hydrogels containing a cross-linked hyaluronic acid (HA) network and investigated their antioxidant activities. Methods : In the first step, we made poly hydroxyethyl methacrylate(p(HEMA))-based hydrogels post-modified with an interpenetrating polymer network(IPN) structure composed of HA polymers and a p(HEMA) network. The subsequent functionalization with dopamine via an amide coupling reaction resulted in the antioxidant hydrogels. Their antioxidant activities were evaluated using 2,2’-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) and 2,2-diphenyl-1-picrylhydrazyl radical scavenging assays. Results : The dopamine-modified hydrogels exhibited significant antioxidant activities, whencompared to unmodified control. The presence of the HA–IPN structure improved the surface wettability of the hydrogel while dopamine-conjugated IPN hydrogel did not demonstrate the significant difference compared to hydrogel control. Dopamine-modified hydrogels exhibited high transmittance (>88%). Conclusion : The results demonstrate that the development of antioxidant hydrogels based on dopamine-conjugated HA–IPN structures may help develop ophthalmic and biomedical materials.