심룡근(心朧筋)의 반복수축현상(反復收縮現象)에 관(關)하여

여웅연,Ryo, Ung-Yun,Brooks, Chandler Mcc. 대한생리학회 1967 대한생리학회지 Vol.1 No.1

Present paper is attempted to introduce the phenomenon of 'after contraction' in isolated cardiac-muscle. Papillary muscles were removed from cat right ventricle and were used as a preparation. The muscle strip was Placed in tissue bath which is kept in steady temperature of around $25^{\circ}C$ and was perfuced by Tyrode solution, saturated with 95% $O_2$ and 5% $CO_2.$ under the condition of high calcium (8.2-10.0 mM/l), low sodium (72.4-70.0 mM/l) perfusion with the administration of epinephrine (1-2 mg/l) into tile tissue bath normally triggered muscle contraction was followed by oscillatory, repetitive contractions - after contraction. The phenomenon of after contraction was augumented by decrease in tissue bath temperature and by increase in number of preceding beats and in driving rate. Authors were able to maintain the phenomenon in prominent and steady state giving proper experimental conditions such as fixed bath temperature (ranged from $22^{\circ}C\;to\;27^{\circ}C$), suitable driving rate (20 per minute in average) and perfusion of high calcium, loll sodium and 1-2 mg/l of epinephrine. In some preparations, the strength of after contraction (second contraction) reached up-to 80% of normally triggered contraction and five repetitive contractions were observed as largest number of after contractions. Intracellular action potential measured in the muscle which was beating regulary showing steady after contraction revealed no oscillating after potential in most parts of the muscle but in few cases oscillating changes of after potentials were detectable. In electrogram of the muscle preparation recorded by means of contact electrode prominent, oscillating after potentials were observable when the recorder was set at highest sensitivity. It still is not clear that whether after contraction is the phenomenon which corresponds to those changes in action potential, oscillating after potential, of the muscle preparation. Possible mechanism of the phenomenon of after contraction relating with after potential changes was proposed. Detailed results obtained from further studies on after contraction and concrete discussion on the phenomenon will be reported by authors.

일산화탄소중독견(一酸化炭素中毒犬) 체내(體內)에서의 일산화탄소처리능(一酸化炭素處理能)에 관(關)하여

여웅연(Ryo, Ung-Yun),강반(Kang, Bann) 대한생리학회 1968 대한생리학회지 Vol.2 No.2

The Present study attempted to analyze the fate of CO diffused into the circulating blood through the alveoli. Dogs were induced to CO poisoning by rebreathing CO gas mixture contained in Krog s spirometer, by closed circuit method, for 60 minutes. The spirometer was filled initially with 282 ml of CO and 20 liters of air and oxygen, so the composition of gases were arranged as 1.4% in CO and 50% in O₂ at the begining of the rebreathing. Oxygen was added corresponding to the utilization of O₂ by the animal in proceeding of the experiment. At 60th minutes of CO rebreathing, the concentration of CO in arterial blood and in mixed venous blood were analysed and compared with each other after the CO contents were corrected with the hematocrit measured in the arterial and mixed venous blood. The distribution of CO gas to other tissues was estimated by the analysis of CO diffused into the cystic bile and into the peritoneal gas pocket which was formed by injection of 300 ml air into the peritoneal cavity prior to the CO gas rebreathing. The blood volume was measured by dilution method using ⁵¹Chromium tagged red cells. CO amount vanished in the animal body was calculated by subtraction of total CO content in blood stream and the CO remained in closed circuit breathing system from the CO amount given to the breathing system at the begining of the experiment. Results obtained are summarized as follows: 1. The content of CO corrected by the hematocrit value was slightly less in mixed venous blood than in arterial blood. The amount of CO diffused into the cystic bile and into the peritoneal cavity was averaged to 0.1% and 0.4% of the CO amount in 100 ml of blood, respectively. 2. For 60 minutes of CO rebreathing, CO-hemoglobin saturation reached about 77% at the 60th minutes, CO amount vanished in the experimental animal averaged 36.1 ml/dog/hr., or 21% of the total CO volume in the blood stream. The average vanishing rate of CO during 60 minutes of CO rebreathing per kg of body weight was 2.71 ml/hr. Production of CO measured in ten dogs under hypoxic condition averaged 0.023 ml/kg/hr. The major part of the CO vanished in the dogs seemed to be oxidized to CO₂ by various tissues of the animal. The conclusion might be delivered as such oxidation of CO to CO₂ by animal tissues can play a role in part of the process of recovery and protection of animal from CO-poisoning.

일산화탄소중독시(一酸化炭素中毒時) 폐(肺)로 부터의 일산화탄소(一酸化炭素) 방산(放散)에 관(關)하여

강반(Kang, Bann),김근주(Kim, Kun-Joo),여웅연(Ryo, Ung-Yun) 대한생리학회 1967 대한생리학회지 Vol.1 No.2

In order to evaluate the elimination of CO through the lung comparing with the decrease of CO content in the blood, authors had induced acute CO poisoning on 9 dogs. Arterial CO-Hb saturation, CO concentration, %, in expired gas and eliminated CO amount through the lung were measured at 1,5,10,30,60, and 120 minutes after acute CO poisoning in 6 dogs breathing room air and 3 dogs breathing room air and oxygen alternately. Results obtained are summarized as follows. In room air breathing group, arterial CO-Hb saturation averaged 50.8% , and 53.67 ml of CO was blew off through the lung during 120 minutes and in alternately air and oBygen breathing group, the arterial CO-Hb saturation averaged 65.6% and 95.6 ml of CO was blew off through the lung. The amount of CO eliminated in expired gas for 120 minute was much less than the amount of decreased CO in arterial blood which was calculated with the decreased CO-Hb content in the estimated circulating blood volume. Such difference between the amount of eliminated CO in expired gas and the decreased CO in blood might be attributed to the oxidation of CO to CO₂ in the tissues. Concentration of CO in expired gas was markedly increased and the rate of decrease in arterial CO-Hb saturation is enhanced by oxygen breathing. In early period of recovery from acute CO poisoning, neither the CO concentration in expired gas, nor, the rate of CO elimination (unlit 2 minutes after CO poisoning) showed close correlation with the blood CO-Hb saturation level. The reason seemed to be due to irregularly depressed or unevenly stimulated respiration which were induced by acute CO poisoning.

사람의 消化管內 Gas 組成

李鶴九(Hack Koo Lee),全烈慶(Yul Kyung Chun),呂雄淵(Ung Yun Ryo) 대한외과학회 1967 Annals of Surgical Treatment and Research Vol.9 No.7

數種 Steroids의 白鼠赤血球 Fragility에 미치는 影響

呂雄淵,姜班 慶北大學校 醫科大學 1963 慶北醫大雜誌 Vol.4 No.1

數種 Steroids의 白鼠赤血球 Fragility에 미치는 影響

呂雄淵,姜班 慶北大學校 醫科大學 1963 慶北醫大誌 Vol.4 No.1

The effects of Steroid, both injected intramusculary and added directly in vitro, on the red cell fragility were studied, and the following results were obtained. 1. In two groups where 1) 1.25㎎ of Cortisone and 2) 1.0㎎ of Prednisolone were injected intramusculary, the red cell osmotic fragility was significantly decreased 7 hours after the injection. 2. The Testosterone and Cortisone showed no remarkable effect on the red cell osmotic fragility in vitro during 20 hours. 3. As a control, the authors studied the red cell fragility in normal rats, and a relation curve of the hemoglobin percentage in hemolyzed solution and transmittancy in Spectrophotometer, were obtained.

寒冷露出, X-線照射 및 數種 Steroid가 赤血球 Fragility에 미치는 影響에 關하여

呂雄淵 최신의학사 1963 最新醫學 Vol.6 No.5

一酸化炭素 中毒犬에서 發見된 律動的 頻度變化 呼吸型

呂雄淵 대한의학협회 1968 대한의학협회지 Vol.11 No.10

一酸化炭素 Gas Pocket에 관한 硏究

呂雄淵 대한의학협회 1964 대한의학협회지 Vol.7 No.11

흰쥐의 腹腔內에 投與한 C0^60 - Vitamin B_12의 臟器內分布 및 排泄에 관하여

張益柱,金圭秀,呂雄淵 慶北大學校 1964 論文集 Vol.8 No.-

Present study describes on the distribution of intraperitoneally administered Co^60-Vitamin B_12 in the liver, kidney and spleen, as well as its fecal excretion in the rats. The albino rats were administered 48.3μ㎎ of Co^60-Vitamin B_12 intraperitoneally and were sacrified by decapitation on the 3rd day after Vitamin B_12 administraion. The liver, kidney and spleen were removed and the rats' feces were collected every day for 3 days. The contents of Co^60-Vitamin B_12 in the liver, kidney, spleen and the feces were measured with the well type scintillation counter and the data were compared with the orally administered control group. The results were as follows; 1. The mean contents of Co^60-Vitamin B_12 in intraperitoneally administered rat's liver, kidney and spleen were 3-5 times more than those of control group. 2. Fecal excretion rate of intraperitoneally administered Co^60-Vitamin B_12 was markedly less than that of control group. And the total amount of excreted Co^60-Vitamin B_12 in feces was comparatively more than generally expected amount in the intraperitoneally administered group. 3. The authors were impressed that the absorption rate of intraperitoneally administered Vitamin B12 was significantly less than that of intramuscularly or intravenously administered Vitamin B_12, reported by other authors. 4. The above results indicate that a further study is necessary to prove the exact mechanism of absorption and fecal excretion of intraperitoneally administered Vitamin B_12.