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數種 Steroids의 白鼠赤血球 Fragility에 미치는 影響
呂雄淵,姜班 慶北大學校 醫科大學 1963 慶北醫大誌 Vol.4 No.1
The effects of Steroid, both injected intramusculary and added directly in vitro, on the red cell fragility were studied, and the following results were obtained. 1. In two groups where 1) 1.25㎎ of Cortisone and 2) 1.0㎎ of Prednisolone were injected intramusculary, the red cell osmotic fragility was significantly decreased 7 hours after the injection. 2. The Testosterone and Cortisone showed no remarkable effect on the red cell osmotic fragility in vitro during 20 hours. 3. As a control, the authors studied the red cell fragility in normal rats, and a relation curve of the hemoglobin percentage in hemolyzed solution and transmittancy in Spectrophotometer, were obtained.
심룡근(心朧筋)의 반복수축현상(反復收縮現象)에 관(關)하여
여웅연,Ryo, Ung-Yun,Brooks, Chandler Mcc. 대한생리학회 1967 대한생리학회지 Vol.1 No.1
Present paper is attempted to introduce the phenomenon of 'after contraction' in isolated cardiac-muscle. Papillary muscles were removed from cat right ventricle and were used as a preparation. The muscle strip was Placed in tissue bath which is kept in steady temperature of around $25^{\circ}C$ and was perfuced by Tyrode solution, saturated with 95% $O_2$ and 5% $CO_2.$ under the condition of high calcium (8.2-10.0 mM/l), low sodium (72.4-70.0 mM/l) perfusion with the administration of epinephrine (1-2 mg/l) into tile tissue bath normally triggered muscle contraction was followed by oscillatory, repetitive contractions - after contraction. The phenomenon of after contraction was augumented by decrease in tissue bath temperature and by increase in number of preceding beats and in driving rate. Authors were able to maintain the phenomenon in prominent and steady state giving proper experimental conditions such as fixed bath temperature (ranged from $22^{\circ}C\;to\;27^{\circ}C$), suitable driving rate (20 per minute in average) and perfusion of high calcium, loll sodium and 1-2 mg/l of epinephrine. In some preparations, the strength of after contraction (second contraction) reached up-to 80% of normally triggered contraction and five repetitive contractions were observed as largest number of after contractions. Intracellular action potential measured in the muscle which was beating regulary showing steady after contraction revealed no oscillating after potential in most parts of the muscle but in few cases oscillating changes of after potentials were detectable. In electrogram of the muscle preparation recorded by means of contact electrode prominent, oscillating after potentials were observable when the recorder was set at highest sensitivity. It still is not clear that whether after contraction is the phenomenon which corresponds to those changes in action potential, oscillating after potential, of the muscle preparation. Possible mechanism of the phenomenon of after contraction relating with after potential changes was proposed. Detailed results obtained from further studies on after contraction and concrete discussion on the phenomenon will be reported by authors.
일산화탄소중독견(一酸化炭素中毒犬) 체내(體內)에서의 일산화탄소처리능(一酸化炭素處理能)에 관(關)하여
여웅연(Ryo, Ung-Yun),강반(Kang, Bann) 대한생리학회 1968 대한생리학회지 Vol.2 No.2
The Present study attempted to analyze the fate of CO diffused into the circulating blood through the alveoli. Dogs were induced to CO poisoning by rebreathing CO gas mixture contained in Krog s spirometer, by closed circuit method, for 60 minutes. The spirometer was filled initially with 282 ml of CO and 20 liters of air and oxygen, so the composition of gases were arranged as 1.4% in CO and 50% in O<sub>2</sub> at the begining of the rebreathing. Oxygen was added corresponding to the utilization of O<sub>2</sub> by the animal in proceeding of the experiment. At 60th minutes of CO rebreathing, the concentration of CO in arterial blood and in mixed venous blood were analysed and compared with each other after the CO contents were corrected with the hematocrit measured in the arterial and mixed venous blood. The distribution of CO gas to other tissues was estimated by the analysis of CO diffused into the cystic bile and into the peritoneal gas pocket which was formed by injection of 300 ml air into the peritoneal cavity prior to the CO gas rebreathing. The blood volume was measured by dilution method using <sup>51</sup>Chromium tagged red cells. CO amount vanished in the animal body was calculated by subtraction of total CO content in blood stream and the CO remained in closed circuit breathing system from the CO amount given to the breathing system at the begining of the experiment. Results obtained are summarized as follows: 1. The content of CO corrected by the hematocrit value was slightly less in mixed venous blood than in arterial blood. The amount of CO diffused into the cystic bile and into the peritoneal cavity was averaged to 0.1% and 0.4% of the CO amount in 100 ml of blood, respectively. 2. For 60 minutes of CO rebreathing, CO-hemoglobin saturation reached about 77% at the 60th minutes, CO amount vanished in the experimental animal averaged 36.1 ml/dog/hr., or 21% of the total CO volume in the blood stream. The average vanishing rate of CO during 60 minutes of CO rebreathing per kg of body weight was 2.71 ml/hr. Production of CO measured in ten dogs under hypoxic condition averaged 0.023 ml/kg/hr. The major part of the CO vanished in the dogs seemed to be oxidized to CO<sub>2</sub> by various tissues of the animal. The conclusion might be delivered as such oxidation of CO to CO<sub>2</sub> by animal tissues can play a role in part of the process of recovery and protection of animal from CO-poisoning.