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Potassium Chloride 및 Acetylcholine 이 위저평활근수축에 미치는 영향
황장용(Jang Yong Hwang),안병철(Byeong Cheal Ahn),윤영미(Young Mee Youn),김성국(Sung Kook Kim),권영오(Young Oh Kweon),최용환(Yong Hwan Choi),정준모(Joon Mo Chung),김중영(Choong Young Kim) 대한내과학회 1995 대한내과학회지 Vol.49 No.5
N/A Objectives: To examine the relation of acety1choline(ACh)-and potassium chloride(KCl)-induced contraction to utilization of extracellular calcium in gastric smooth muscles, we studied. Methods: Using isolated longitudinal muscle of mouse gastric fundus, ACh-and KC1-induced isotonic contractions were compared with the contractions in the presense of calcium channel antagonists (diltiazem, verapaimil). Results: 1) By the addition of ACh(10(-2)mM), submaximal contractions developed at 30second, then to be maximal level of contraction at 1minute which sustained for 6minutes. However, by the addition of KCl(1,8mM), the smooth muscle contraction progressively increased to reach maximal level at 6minutess, 2) The ACh-induced contractions were not affected by various concentration of diltiazem(4.4±10(4)~4.4±10(-3)mM) and verapamil(7.3±10(-3),6±10(-2)mM). However, the KCl-induced contractions were depressed by diltiazem and verapamil in dose-dependently. Conclusion: These results suggest that KCI- induced contractions of gastric fundus smooth muscle utilize extracellular calcium, however Ach-induced contractions of the smooth muscle do not.
羅蓮淑,鄭英採,金敎善,黃長龍,崔龍煥,鄭俊謨 慶北大學校 醫科大學 1984 慶北醫大誌 Vol.25 No.2
應急實을 방문하는 患者중 吐血과 血便을 主訴로 하는 患者 123名에게 緊急內視鏡檢査를 施行하여 다음과 같은 成績을 얻었다. 對象은 男子가 86.2%, 女子가 13.8% 이었으며 50代가 35.8%로 가장 많았다. 出血部位는 胃가 가장 많았고 病別로는 胃潰瘍이 43.1%, 食道靜脈瘤 19.5%, 다음이 Mallory-Weiss 裂傷, 十二指腸潰瘍의 順이었다. 과거의 出血病歷이 없었던 예가 81.3%로 가장 많았고 3번이상 經驗한 例가 5.5% 이었으며 出血후 6時間 이내에 內視鏡檢査를 施行하 예는 23.1% 이었는데 87.9%가 24時間 이내에 檢査를 받았다. 輸血을 받지 않는 경우가 25.6% 이었으며 5단위 이상받은 예는 38.9%이었다. 胃出血患者中 誘發因子로 推定되는 것으로는 알콜, 副腎皮質홀몬제, 감기약, 鎭痛劑등이 있었다. Urgent endoscopy was performed for one hundred twenty three patients who were admitted to emergency room due to hematemesis and/or melena by upper gastrointestinal bleeding. The ratio of men to women was approximately 6:1 and peak incidence was in the 6th decade. The sources of bleeding were in the order of gastric ulcer(43.1%), esophageal varices(19.5%), Mallory-Weiss tear(10.6%) and duodenal ulcer(9.8%) etc. No previous history of upper gastrointestinal hemorrhage was noted in 81.3% of the patients and also more than 3 times of that was noted in 5.5% of the patients. Urgent endoscopy was performed within 6 hours after bleeding episode in 23.1% of the patients but within 24 hours it was 87.9%. 25.6% of the patients required no transfusion and 38.9% of the patients required mord than 5 units of blood. The possible causative agents of gastric bleeding in these cases included alcohol, steroids, drugs for the cold, analgesics, and herb drugs.
김대환,김영재,정준모,최용환,정영채,김교선,이국희,황장용 대한소화기내시경학회 1984 Clinical Endoscopy Vol.4 No.1
Clinical and endoscopic features on 86 patients with acute upper gastrointestinal mucosal lesien were evaluated. Males were predaminant about 3 times of female. Most of patients were in 4 th to 6 th decade. The prevalent locations were proximal part of the stomach and dodenal bulb. Most,freqent chief camplaints was epigastric pain. Eeloscopieally aoute ulcers were characterized by shallow in depth, variant size and shape, rather clear ulcer margin without mucosal fold eonvergence and multiple lesions rather than sigle. The inducing factors of the acute mucosal lesiona whiah were noted were alcohol, HCI, analgesics, herb drug, steroid, antibiotlies and orgaaie ipheephorus.