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홍승화,권혜은,김성훈,채희동,김정훈,강병문,Hong, Seung-Hwa,Kwon, Hye-Eun,Kim, Sung-Hoon,Chae, Hee-Dong,Kim, Chung-Hoon,Kang, Byung-Moon 대한생식의학회 2003 Clinical and Experimental Reproductive Medicine Vol.30 No.3
Ectopic pregnancy is a common medical problem that is difficult to diagnose and potentially may lead to significant mortality or morbidity. The incidence of ectopic pregnancy is definitely increasing ue to the rise in pelvic inflammatory disease (PID), pelvic surgery, intrauterine device (IUD), and assisted reproductive technologies, such as in vitro fertilization and embryo transfer (IVF-ET). Combined ectopic gestations are much rare and their true incidence is unknown. Multiple ectopic gestations may occur in a variety of locations. The majority involve one or both fallopian tubes. We report a case of combined tubal and cervical pregnancies, and discuss their management.
한국인 중증 전자간증 산모에서 Thermolabile Methylenetetrahydrofolate Reductase 유전자의 다양성에 관한 연구
홍승화(Seung Hwa Hong),김용범(Yong Beom Kim),지일운(Ill Woon Ji),정은환(Eun Hwan Jeong),김학순(Hak Soon Kim),노재숙(Jae Sook Rho),김정규(Jeong Kyu Kim),조명찬(Myeong Chan Cho) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.11
N/A Objective : This study was performed to evaluate C to T substitution at nucleotide 677 of meth- ylenetetrahydrofolate reductase gene in Korean women, which is genetically homogeneous, with preeclamptic or normotensive pregnancies. Methods : Methylenetetrahydrofolate reductase genotypes were determined in 63 Korean women with severe preeclamptic pregnancies and 60 controls with normotensive pregnancies, using polymerase chain reaction and restriction enzyme analysis. Results : The methylentetrahydrofolate reductase genotype and allele frequencies in preeclamptic and control women did not differ significantly. The frequency of the T677 allele was 38.1% in the preeclamptic group and 41.7% in the control group, and TT homozygosity was found in 12 preeclamptic women (19.0%) and 10 controls (16.7%). Conclusion : It seems like that there is no evidence of association of preeclampsia with methylenetetrahydrofolate reductase gene polymorphism, at least in the Korean population.
한국인 전자간증 임부에서 Factor V 유전자의 다형성에 관한 연구
홍승화 ( Seung Hwa Hong ),김정규 ( Jeong Kyu Kim ),최정원 ( Jeong Weon Choi ),지일운 ( Ill Woon Ji ),정은환 ( Eun Hwan Jeong ),김학순 ( Hak Soon Kim ) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.11
목적: 본 연구는 한국의 전자간증 임부에서 전자간증과 factor V 유전자의 다형성간에 연관성을 평가하는데 그 목적이 있다. 연구 방법: 2000년 3월부터 2002년 3월까지 충북대학병원을 방문하여 분만한 100명의 정상 대조군과 113명의 전자간증 임부를 대상으로 말초혈액채취의 방법으로 DNA를 얻어 PCR을 시행하고 제한효소로 절단하여 2% 한천젤에 전기영동하였으며, 자외선 형광하에서 절단된 band의 크기를 확인하였다. 결과: 정상 대조군과 전 Objective: This study was to evaluate the association of the G1691A mutation of factor V gene with preeclamptic patients in Korea. Methods: Factor V genotype were determined in 113 preeclamptic patients and 100 normotensive pregnant women. A 267 base-pair
이상경 ( Sang Kyoung Lee ),홍승화 ( Seung Hwa Hong ),박연진 ( Yeon Jin Park ),지일운 ( Il Woon Ji ),정은환 ( Eun Hwan Jeong ),김학순 ( Hak Soon Kim ),김용민 ( Yong Min Kim ) 대한주산의학회 2005 Perinatology Vol.16 No.4
Cauda equina syndrome develops as rapidly progressive neurologic deficit of lower extremities and urogenital system often resulting in serious outcome such as complete irreversible paraparesis, therefore prompt diagnosis and decompression is mandatory. However, if it occurs after childbirth, it may be overlooked being regarded as symptoms related to pregnancy and delivery. We experienced a cauda equina syndrome by prolased disc in a 32-year-old woman just after Caesarian section who was managed with prompt decompressive surgery and achieved favorable result. Because of the importance of early detect and prompt decompression for cauda equina syndrome and possible occurrence at perinatal period, we report this case reviewing the literature especially concerning about changes of spine and disc during pregnancy and after delivery.
자궁내막증 환자의 자궁내막 및 이소성 자궁내막조직에서의 혈관내피성장인자 수용체 전령리보핵산의 발현
박정열 ( Park Jeong Yeol ),김정훈 ( Kim Jeong Hun ),홍석호 ( Hong Seog Ho ),이영진 ( Lee Yeong Jin ),홍승화 ( Hong Seung Hwa ),권혜은 ( Kwon Hye Eun ),김성훈 ( Kim Seong Hun ),채희동 ( Chae Hui Dong ),강병문 ( Kang Byeong Mun ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.3
목적 : 본 연구는 자궁내막증 환자의 이소성 자궁내막과 정상 위치의 자궁내막 그리고, 자궁내막증이 없는 환자의 자궁내막에서 혈관내피성장인자 수용체 (vascular endothelial growth factor receptor, VEGFR) 의 발현정도를 비교하기 위하여 시행되었다. 연구 방법 : 양성 부인과 질환의 수술적 치료를 통하여, 자궁내막증으로 확인된 환자들을 실험군으로 하였으며, 자궁내막증이 없는 환자들을 대조군으로 하였다. 실험군의 이소성 자궁내막조직 및 정상 위치의 자궁 내막조직과 대조군의 자궁내막조직내의 혈관내피성장인자 수용체의 전령리보핵산 (messenger ribonucleicacid, mRNA)의 발현정도는 실시간 역전사 중합효소연쇄반응 (real time reverse transcriptase-polymerase chain reaction, RT-PCR)응 이용하여 정량화하였고, ANOVA (analysis of variance)와 Kruskal-Wallis test로 차이를 분석하였다. 결과 : 환자군의 경우 정상 위치 및 이소성 자궁내막내 혈관내피성장인자수용체-1, -2, -3 mRNA 모두 증식기와 분비기 모두에서 대조군에 비해 유의하게 증가해 있었다. 한편 자궁내막증 환자의 이소성 자궁내막조직에서의 혈관내피성장인자 수용체-1은 후기증식기에 비해 중간분비기때 유의하게 증가하였고 혈관내피성장인자 수용체-3의 경우엔 후기증식기에 비해 중간분비기때 유의하게 감소하는 양상을 나타냈다. 특히 자궁내막증 환자의 이소성 후기증식기 자궁내막조직에서의 혈관내피성장인자 수용체-3은 대조군의 후기증식기 및 중간분비기 자궁내막조직에 비해서는 물론 자궁내막증 환자의 정상 자궁내막에서의 후기증식기 및 중간분비기 자궁내막조직에 비해서도 뚜렷하게 높은 발현 양상을 보였다. 결론 : 이상의 결과는 자궁내막증의 발생에 혈관내피성장인자 수용체 전령리보핵산의 발현 증가가 관여되어있음을 시사하고, 이들중 특히 혈관내피성장인자 수용체-1, 3은 월경주기에 따른 변화 양상을 나타내는 것으로 보아 혈관내피성장인자가 자궁내막증의 발생에 자가분비 및 주변분비 방식으로 관여할 가능성이 있는 것으로 보인다. 특히 혈관내피성장인자 수용체-3은 이소성 자궁내막조직의 증식과 높은 관련성을 갖는 것으로 보인다. Objective : To Investigate the expression of vascular endothelial growth factor receptor-1, -1, and -3 (VEGFR-1, -2, and -3) mRNA in the eutopic and ectopic tissues in women with endometriosis. Methods : At the time of laparoscopy or laparotomy for endometriosis, infertility or other benign gynecologic conditions, a biopsy specimen was taken from the endometrial cavity and a peritoneal endometriotic implant simultaneously whenever appropriate. For control samples, endometrial tissues were obtained from women without visual evidence of endomtriosis. We employed real time quantitative RT-PCR to quantify VEGFR gene expression of these tissues. Comparisions between each group were made using ANOVA (analysis of variance) and Kruskal-Wallis test and statistical significance was defined as p<0.05. Results : The expression of VEGFR-1, -2, and, -3 mRNA was significantly higher in both eutopic and ectopic endometrial tissues of women with endometriosis than in control endometrial tissues during both proliferative and mid-secretory phase. In ectopic endometrial tissue, VEGFR-1 mRNA expression was significantly increased during the mid-secretory phase compared to the proliferative phase. There was a marked increase especially in VEGRF-3 mRNA expression in ectopic endometriotic lesions during the proliferative phase but its expression decreased during the mid-secretory phase. Conclusion : mRNA for VEGFR-1, -2, and -3 in an endometriotic lesions might be differentially expressed and their expression appears to be associated with the development of endometriosis.
단일 융모막 쌍태아에서 한쪽 태아의 터너 증후군 증례 보고
장정희 ( Jeong Hui Jang ),경규상 ( Kyu Sang Kyeong ),홍덕호 ( Deok Ho Hong ),홍승화 ( Seung Hwa Hong ),지일운 ( Il Woon Ji ),정은환 ( Eun Hwan Jeong ) 대한주산의학회 2014 Perinatology Vol.25 No.4
Monochorionic twins with discordant karyotypes are rare and mostly caused by post-zygotic mitotic nondisjunction. A 32 year old nulliparous woman at 11 weeks of gestation with spontaneous twin pregnancy wasreferred to our hospital. An amniocentesis was performed in both amniotic sacs at 15 weeks of pregnancy. Onefetus in monochorionic twin pregnancy was diagnosed with Turner syndrome with cystic hygroma, and theother fetus was normal. Because of high mortality rate in abnormal fetuses, the umbilical cord coagulation wasperformed using radiofrequency ablation to prevent the damage of co-twin that may be caused by the demiseof one fetus. After delivery, chorionicity of placenta was ascertained by pathologic exam. Postnatal findings ofphysical exam, abdominal and brain sonography were normal in the surviving neonate.
선택적 태아감수술을 이용하여 성공적으로 만삭분만에 이른 자궁각 임신을 동반한 병합임신
이지영 ( Lee Ji Yeong ),오지영 ( O Ji Yeong ),홍승화 ( Hong Seung Hwa ),권혜은 ( Kwon Hye Eun ),김성훈 ( Kim Seong Hun ),채희동 ( Chae Hui Dong ),김정훈 ( Kim Jeong Hun ),강병문 ( Kang Byeong Mun ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.9
Heterotopic pregnancy refers to the simultaneous occurrence of an ectopic gestation with an intrauterine one. The incidence of heterotopic pregnancy in the general population is about 1 to 30,000 pregnancies, but it has been increased due to the rise in p
태아심박동이 있는 자궁경관임신에서 태낭내 methotrexate 직접주입법에 의한 보존적 치료
신서규(Seo Kyu Sin),윤태진(Tae Jin Yoon),홍승화(Seung Hwa Hong),김용범(Yong Beom Kim),지일운(Ill Woon Ji),정은환(Eun Hwan Jeong),김학순(Hak Soon Kim) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.11
N/A Objective : The purpose of this study was to determine the effectiveness of intra-amniotic methotrexate instillation for the treatment of viable cervical pregnancy. Materials and Methods : Four patients were enrolled in this study after confirmation of cervical pregnancy by ultrasonography. Viable cervical pregnancy was determined by ultrasonographic findings with the entire chorionic sac containing a live fetus below the internal os, empty uterine cavity, and significantly dilated or barrel shaped cervical canal. Under the transvaginal ultrasonographic guidence, 50 mg of methotrexate was injected directly into the amniotic sac after complete aspiration of amniotic fluid. Serial serum β-human chorionic gonadotropin (β-hCG) was evaluated weekly until normalized. Results : All the patients were successfully treated with conservative method and one patient received hysterectomy due to arterio-venous malformation diagnosed during follow up. Initial serum β-hCG concentration was 22,484-93,803 mIU/ml and decreased by log scale after treatment. Conclusion : Intra-amniotic methotrexate instillation without concomitant feticide injection or feticidal procedure can be used for the initial treatment in viable cervical pregnancy. Initial titer or falling rate pattern of serum β-hCG did not seem to be related with the prognosis.