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기업의 사회적 책임과 기업이미지가 정부이미지에 미치는 영향 분석
현성애,항윤원 한국인사행정학회 2019 한국인사행정학회보 Vol.18 No.3
본 연구는 기업의 사회적 책임(CSR: Corporate Social Responsibility)과 기업이미지가 정부이미지에 어떻게 영향을 미치는가에 대해 설문조사를 통해 검증했다. 조사 결과, 세 집단(대학생, 일반인, 공무원)별로 상이한 결과가 나타났다. 먼저, 대학생 및 일반인 집단은 기업이미지와 정부이미지 간 긍정적 관계가 확인되었으나, 공무원 집단에서는 의미 있는 차이가 나타나지 않았다. 한편, CSR이 정부이미지에 미치는 영향을 살펴본 결과, 대학생 집단에서는 CSR이 효율성을 제외한 정부이미지 모두에 긍정적 영향을 미치는 것으로 나타났다. 또한 일반인 집단에서는 미래지향성을 제외한 나머지 정부이미지 요인에 경제적 CSR이 긍정적 영향을 미치는 것으로 나타났고, 공무원 집단에서는 CSR이 정부이미지에 아무런 영향을 미치지 않는 것으로 나타나 기업이미지를 독립변수로 삼았을 경우와 유사한 결과를 보였다. 요약컨대, 본 연구에서는 CSR 활동에 대한 대중의 평가뿐만 아니라 기업이미지에 대한 일반적 견해도 정부이미지에 긍정적 영향을 미치는 것으로 나타나 정부의 직접적인 CSR 관리를 통해 긍정적인 정부이미지 형성을 기대할 수 있을 것으로 보인다. 따라서 정부는 CSR에 대한 관리와 장려가 필요하다는 정책적 시사점을 도출할 수 있다.
Comparison of electrophysiological effects of calcium channel blockers on cardiac repolarization
이향애,현성애,박성걸,김기석,김성준 대한약리학회 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.1
Dihydropyridine (DHP) calcium channel blockers (CCBs) have been widely used to treat of several cardiovascular diseases. An excessive shortening of action potential duration (APD) due to the reduction of Ca2+ channel current (I Ca) might increase the risk of arrhythmia. In this study we investigated the electrophysiological effects of nicardipine (NIC), isradipine (ISR), and amlodipine (AML) on the cardiac APD in rabbit Purkinje fibers, voltage-gated K+ channel currents (I Kr, I Ks) and voltage-gated Na+ channel current (I Na). The concentration-dependent inhibition of Ca2+ channel currents (I Ca) was examined in rat cardiomyocytes; these CCBs have similar potency on I Ca channel blocking with IC50 (the half-maximum inhibiting concentration) values of 0.142, 0.229, and 0.227 nM on NIC, ISR, and AML, respectively. However, ISR shortened both APD50 and APD90 already at 1 μM whereas NIC and AML shortened APD50 but not APD90 up to 30 μM. According to ion channel studies, NIC and AML concentration-dependently inhibited I Kr and I Ks while ISR had only partial inhibitory effects (<50% at 30 μM). Inhibition of I Na was similarly observed in the three CCBs. Since the I Kr and I Ks mainly contribute to cardiac repolarization, their inhibition by NIC and AML could compensate for the AP shortening effects due to the block of I Ca.
Wide Spectrum of Inhibitory Effects of Sertraline on Cardiac Ion Channels
이향애,김기석,현성애,박성걸,김성준 대한약리학회 2012 The Korean Journal of Physiology & Pharmacology Vol.16 No.5
Sertraline is a commonly used antidepressant of the selective serotonin reuptake inhibitors (SSRIs) class. In these experiments, we have used the whole cell patch clamp technique to examine the effects of sertraline on the major cardiac ion channels expressed in HEK293 cells and the native voltage-gated Ca2+ channels in rat ventricular myocytes. According to the results, sertraline is a potent blocker of cardiac K+ channels, such as hERG, IKs and IK1. The rank order of inhibitory potency was hERG >IK1>IKs with IC50 values of 0.7, 10.5, and 15.2 μM, respectively. In addition to K+ channels, sertraline also inhibited INa and ICa, and the IC50 values are 6.1 and 2.6 μM, respectively. Modification of these ion channels by sertraline could induce changes of the cardiac action potential duration and QT interval, and might result in cardiac arrhythmia.
NF1-B, C bind and repress the TSHβ subunit gene
김기광,송석배,박준호,구완림,현성애,김균언 忠南大學校 大學院 2005 論文集 Vol.23 No.-
TSH β-subunit is a subunit of the TSH, which is produced by thyrotropes of the anterior pituitary grand. TSH β-subunit gene is elaborately regulated by thyrotrope-specific transcription factors. In this study, EMSA and DNase I protection assays were employed to characterize the interactions between nuclear proteins of the thyrotropes and the -577/-565 region of the TSH β-subunit promoter. Interestingly enough, multiple sequence alignments showed that this -577/-565 region is highly conserved among several mammalians including human, chimpanzee, rat, mouse and dog. In addition, transcription factor cluster analysis identified the NF1 binding sequences in these conserved regions. Based on these observations, we demonstrated that NF1 physically interact with the -577/-565 region of the TSH β-subunit promoter and functionally repress the transcription. Taken together, these results suggest that transcription factor NF1 is involved in the TSH β-subunit gene regulation in thyrotropes of the anterior pituitary gland.