개의 적출방광 평활근에서 Imipramine과 $K^+$ 통로 봉쇄제와의 상호작용

허준영,최은미,최형철,하정희,이광윤,김원준,Huh, Joun-Young,Choi, Eun-Mee,Choi, Hyoung-Chul,Ha, Jeoung-Hee,Lee, Kwang-Youn,Kim, Won-Joon 대한약리학회 1995 대한약리학잡지 Vol.31 No.2

The study was undertaken to examine the possibility of the involvement of $K^+$ channels in the mechanism of relaxant-action of imipramine on the isolated canine detrusor muscle strips. Canine urinary bladder were isolated, and smooth muscle strips of 15 mm long and 2 mm wide from the mid-portion of anterior wall were made in the Tyrode solution of $0{\sim}4^{\circ}C$. The strips were prepared for isometric myography in Biancani's isolated muscle chamber containing 1 ml of Tyrode solution, which was maintained with pH 7.4 by aeration with $95%\;O_2/5%CO_2\;at\;37^{\circ}C$. RP 52891, a non-specific $K^+$ channel opener, concentration-dependently suppressed the spontaneous phasic contractions of the detrusor strips. Imipramine, a tricyclic antidepressant, also reduced the spontaneous contractions in a concentration-dependent manner. RP 52891 was more potent than imipramine(p<0.05), and Imipramine was more efficient than RP 52891(p<0.05).Procaine, a voltage-dependent $K^+$ channel blocker, glibenclamide, an ATP-dependent $K^+$ channel blocker, and apamin, a calcium-dependent $K^+$ channel blocker antagonized the relaxant effect of RP 52891, but not of imipramine. Imipramine reduced the electric field stimulation (EFS) -induced contractions concentration-dependently. None of the $K^+$ channel blockers employed for this study, procaine, glibenclamide or apamin antagonized the inhibitory action of imipramine on the EFS-induced contraction. These results suggest that in canine detrusor, the $K^+$ channels of the characteristics of voltage-dependent, ATP-dependent and/or calcium-dependent are exist, and the inhibitory action of imipramine on the contractility of the detrusor is independent from the $K^+$ channels.

구강점막에서 약물의 직접적용을 위한 연구

정성희,옥수민,허준영,고명연,안용우,Jeong, Sung-Hee,Ok, Soo-Min,Huh, Joon-Young,Ko, Myung-Yun,Ahn, Yong-Woo 대한안면통증구강내과학회 2010 Journal of Oral Medicine and Pain Vol.35 No.4

A common method for treating oral mucosal diseases is taking medication by oral administration. The oral administration is the method of least resistance. Because large part of drugs is degraded by liver, it is necessary to take more drugs getting to appropriate level in blood stream. And there are so many side effects when patients take drugs by oral administration. In so many cases, the patients who suffer from oral mucosal problems have the other general diseases simultaneously. Willingly or not, some patients can't take the medicine by oral administration. Number of topical drugs for oral mucosal disease is less than that for skin diseases because the environment of oral mucosa prevents activity of medicine. In this paper, research on effects of topical type medication for treating oral mucosal diseases is conducted through investigating currently used medications and their effects. In addition, effects of dissolved oral medications with appropriate solvent are demonstrated if this medication is useful for patients clinically.

구강안면운동장애에 대한 필로카핀의 적용

정성희,옥수민,허준영,고명연,안용우,Jeong, Sung-Hee,Ok, Soo-Min,Huh, Joon-Young,Ko, Myung-Yun,Ahn, Yong-Woo 대한안면통증구강내과학회 2012 Journal of Oral Medicine and Pain Vol.37 No.2

하악 및 구강주위근육의 조절되지 않는 움직임으로 정의 되는 구강안면운동장애(orofacial movement disorder, OMD)는 노인층에서 많이 발생하며 그 원인이 아직 정확히 밝혀지지 않고 치료방법 또한 다양하다. 임상적 특징을 분석하고 치료방법을 연구한 자료는 많이 있으나 타액분비와 OMD의 상관관계에 대한 구체적인 연구는 아직 없다. 본 연구에서는 부산대학교치과병원 구강내과에 내원한 OMD 환자 중 구강건조감을 호소한 4명의 환자를 증례로 하여 필로카핀(pilocarpine)을 경구로 투여한 후 OMD 증상의 변화를 관찰하였다. 연구결과 타액분비량의 저하를 보여 구강건조증으로 진단된 증례와 정상타액분비량을 보이는 증례 모두에서 필로카핀의 경구투여 후 OMD증상의 개선을 보였다. 따라서 향후 OMD와 구강건조증의 상관관계에 대한 추가적인 연구가 필요할 것으로 사료된다. Orofacial movement disorders (OMD) are uncontrolled movement of the muscles involving the face, tongue, lip and mandible. Due to variable oral and lingual muscles affected, the patients with OMD are interfered with the appropriate performance such as chewing, swallowing and talking. In this study, there are 4 OMD cases with oral dryness that saliva flow rate is decreased or not. The symptoms are improved after oral administration of pilocarpine to 4 patients with OMD. Therefore, we suggest that objective or subjective oral dryness could be etiologic factor in OMD and pilocarpine could be regarded as medication for OMD.

구강편평태선에 대한 스테로이드 가글의 효과비교 연구

정성희,박수현,옥수민,허준영,고명연,안용우,Jeong, Sung-Hee,Park, Su-Hyeon,Ok, Soo-Min,Huh, Joon-Young,Ko, Myung-Yun,Ahn, Yong-Woo 대한안면통증구강내과학회 2012 Journal of Oral Medicine and Pain Vol.37 No.1

Oral lichen planus(OLP) is a chronic inflammatory disease with cell-mediated immune responses, but the exact cause is unknown. The treatment aim of OLP is not complete cure but to alleviate symptoms. In this study, two kinds of corticosteroid gargling solutions used for comparing the effects. From 2002 to 2010, 180 patients diagnosed with oral lichen planus and received topical steroid therapy in the Pusan National University Dental Hospital. Each of two types of solution contained dexamethasone (dexamethasone disodium phosphate) and prednisolone ($solondo^{(R)}$). A period of relief of symptoms and recurrence was recorded. The group using solution containing dexamethasone(dexa gargle) was prescribed to 33 patients(25 female, 8 male) and another group containing prednisolone (solon gargle) included 147 patients (114 female, 33 male). The effect of dexa gargle seemed faster than the solon gargle. There was no significant difference for recurrent rate between the groups using dexa and solon gargle. 피부와 구강점막에서 발견되는 편평태선은 만성 염증성 질환으로 세포매개성 면역반응이 주로 언급되고 있으나 아직 정확한 원인은 밝혀지지 않았다. 따라서 완전한 치료법은 아직 없으며 증상의 완화를 치료목표로 하고 있다. 본 연구에서는 구강편평태선의 일차적인 치료법으로 사용되는 corticosteroid의 두 가지 가글용액의 효과를 비교하였다. 2002년부터 2010년까지 부산대학교 치과병원 구강내과에서 구강편평태선으로 진단받은 환자들 중 corticosteroid 가글용액을 처방받은 환자들 총 180명의 환자기록을 조사하였다. 사용된 두 종류의 가글용액은 각각 dexamethasone(dexamethasone disodium phosphate, 0.05%)과 prednisolone($solondo^{(R)}$)을 포함하는 용액이었으며 약물 사용 후 증상의 완화 및 재발의 시기를 기록하여 분석하였다. Dexamethasone gargle(dexa gargle) 처방군은 33명(여성 25명, 남성 8명), prednisolone gargle(solon gargle)처방군은 147명(여성 114명, 남성 33명)이었으며 환자군의 평균연령대는 50대였다. 약물투여 후 초기 2주이내에 증상이 호전된 경우는 dexa gargle을 사용한 환자군에서 유의성 있게 나타났으나 증상재발의 경우는 두가지 가글용액의 차이가 나타나지 않았다. 구강편평태선 환자에 대한 도포용 스테로이드 가글을 이용한 치료에서 증상의 빠른 호전을 기대하기 위해서는 solon gargle보다는 dexa gargle을 사용할 수 있으나 재발율에 있어서는 두 약물의 차이가 발견되지 않았다.

SCL-90-R을 이용한 여성 편평태선 환자분석

김익환,김창용,김경희,허준영,옥수민,정성희,안용우,고명연,Kim, Ik-Hwan,Kim, Chang-Yong,Kim, Kyung-Hee,Huh, Joon-Young,Ok, Soo-Min,Jeong, Sung-Hee,Ahn, Yong-Woo,Ko, Myung-Yun 대한안면통증구강내과학회 2011 Journal of Oral Medicine and Pain Vol.36 No.4

Personal characteristics of female lichen planus patients were analyzed psychologically using the SCL-90-R. The subjects were 51 female lichen planus patients who visited Orofacial pain clinic of the Department of Oral Medicine, Pusan National University Yangsan Dental Hospital from 2009 to 2010. The female control group were collected from Pusan Kyungnam area. 45 female burning mouth syndrome patients, 36 female temporomandibular joint disorder patients, 23 female trigeminal neuralgia patients were subjected at Orofacial pain clinic of the Department of Oral Medicine, Pusan National University Hospital from 1998 to 2010. 1. Lichen planus patients group, burning mouth syndrome patient group, temporomandibular joint disorder patients group, trigeminal neuralgia patients group and the control group were within normal range. 2. The T-Scores of O-C, IS, DEP, ANX, HOS, PHOB in lichen planus patients group were significantly higher than in the control group. 3. The T-Scores of O-C, IS, DEP, ANX, PAR, PSY in chronic group was significantly higher than in acute group. 4. The T-Scores of SOM, O-C, DEP, ANX, in burning mouth syndrome patients group was significantly higher than in lichen planus patient group. 5. There was no significant T-score difference between lichen planus group and temporomandibular joint disorder patient group. 6. There was no significant T-score difference between lichen planus group and trigeminal neuralgia patient group.

SRRS를 이용한 구강 편평태선 환자의 생활변화에 관한 연구

고명연,박수현,옥수민,허준영,안용우,정성희,Ko, Myung-Yun,Park, Su-Hyeon,Ok, Su-Min,Huh, Joon-Young,Ahn, Yong-Woo,Jeong, Sung-Hee 대한안면통증구강내과학회 2012 Journal of Oral Medicine and Pain Vol.37 No.1

편평태선은 피부와 점막에 발생하는 만성 염증성 질환으로써 신체 여러 부위에 침범하여 매우 다양한 임상소견을 나타낸다. 아직 정확한 원인은 밝혀지지 않았으나 피부나 점막에서 유도된 항원변화에 대한 상피와 결체조직 사이의 세포매개성 면역반응에 의한 것으로 알려져 있다. 중년 여성에서 호발하고, 증상의 악화와 완화가 번갈아 일어나는 것이 이 질환의 특징으로, 정신적 스트레스, 유전적 요인, 환경적 요인, 약물 등의 여러 요소가 증상의 악화에 관여하는 것으로 추정된다. 피부 편평태선 환자의 60-70%에서 구강 편평태선이 동반되고, 구강 편평태선 환자의 2/3 가량이 단독병소로써 나타난다. 이번 연구에서는 정서적 스트레스가 구강 편평태선을 악화시키는데 있어 어떤 영향을 미치는지 평가하고자 한다. 임상검사 혹은 조직검사 결과 구강 편평태선으로 진단된 환자 30명과 치과대학 학생들의 부모들 중 구강 편평태선의 증상 및 병력이 없는 30명을 대상으로 하였다. 스트레스 상황의 평가를 위해서는 한국적 문화에 맞게 적절하게 변형한 Holmes와 Rahe의 사회적 재적응 평정척도 설문지(SRRS)를 이용하였다. 분석결과 구강 편평태선 환자들이 대조군에 비해 최근 1년 동안 더 많은 수의 스트레스성 사건들을 경험한 것으로 나타났다. Lichen planus is a chronic inflammatory mucocutaneous disease that affects multiple sites of the body. Often it involves the oral mucosa, but also involve other sites such as skin, genitals, scalp and nails. There is no clear cause of oral lichen planus (OLP), current data suggest that OLP is a T-cell mediated autoimmune disorder which may have an altered self-peptide triggering apoptosis of oral epithelial cells. Usually OLP appears in middle-aged women which tends to be chronic with periods of exacerbation and remission. There are many theories those causes the OLP such as psychological and environmental factors, genetic tendency, drugs and more. 60-70% of lichen planus is accompanied by oral lesions, and more than half of its cases are not able to defined by their skin. In this study, among all the possibility(possible) theories, we tried to evaluate the influence of emotional stress in exacerbating OLP. There were thirty patients with a clinical or histological diagnosis of OLP and other thirty subjects who did not show any signs of systemic disorders include OLP. They were evaluated by using modified Holmes and Rahe's Social Readjustment Rating Scale (SRRS). As a result, a significantly higher level of stress was found in the OLP patients than the control group. Therefore it could be concluded that psychological stressors play an important role in the exacerbating OLP.

만성 신경병성 통증의 약물 치료: 근거-중심의 약물 치료

조상훈,안용우,옥수민,허준영,고명연,정성희,Cho, Sang-Hoon,Ahn, Yong-Woo,Ok, Soo-Min,Huh, Joon-Young,Ko, Myung-Yun,Jeong, Sung-Hee 대한안면통증구강내과학회 2011 Journal of Oral Medicine and Pain Vol.36 No.2

Neuropathic pain is defined by "pain is initiated or caused by primary lesion or dysfunction in the nervous system" and several etiologic conditions can induce the neuropathic pains. Various groups of drugs are used to treat the neuropathic pains. Not depending on anecdotal case or habitual choice, to obtain the more effective pharmacotherapy, relative-comparison index is suggested through multiple analyses of clinical trials. Depending on relative-comparison index, first-line medications and second-line medications for neuropathic pain are recommended. To support the Quality of life in patients, selection of medication is made on such recommendations.

신원불상자의 개인식별에서의 치아의 역할에 대한 고찰

안용우,고철희,허기영,이상섭,옥수민,허준영,고명연,정성희,Ahn, Yong-Woo,Ko, Chul-Hee,Huh, Ki-Yeong,Lee, Sang-Seob,Ok, Soo-Min,Huh, Joon-Young,Ko, Myung-Yun,Jeong, Sung-Hee 대한안면통증구강내과학회 2010 Journal of Oral Medicine and Pain Vol.35 No.2

Forensic odontology in individual identification has been progressing rapidly and its significance has been increasing. But not all individual identification can be done single method solely. Therefore, understanding the advantage and disadvantage of each method is necessary to achieve forensic individual identification properly in each case for it to be applied promptly, economically and precisely. Now We have identified almost 20 case in Busan and Kyeong Nam area in 2008, 2009 and we would like to report some of cases. Finally We will consider role of forensic odontology.

사람 동맥 평활근 세포에 대한 Rosmarinic Acid의 항동맥경화 활성

정재하(Jung Jae Ha),윤현정(Hyun Jeong Yun),허준영(Joon Young Huh),김재은(Jai Eun Kim),박선동(Sun Dong Park) 한의병리학회 2009 동의생리병리학회지 Vol.23 No.6

호산구성 (好酸球性) 위장염 (胃腸炎) 보고

안성훈(Sung Hoon Ahn),박승국(Seung Kook Park),허정욱(Jung Wook Hur),박성배(Seong Bae Park),허준영(Joon Young Huh),이택근(Taek Geun Lee) 대한소화기학회 1984 대한소화기학회지 Vol.16 No.1

Eosinophilic gastroenteritis is an uncommon disease charaterized by abdominal pain, vomiting, diarrhea, eosinophilia in peripheral blood and eosinophilic infiltration of gut. We experienced a case of eosinophilic gastroenteritis, which developed after ingestion of medicinal plant, Acanthopanax sessili florum, reported with review of literature.