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난치성 사마귀 치료에 대한 인유두종 바이러스 4가 항원 백신의 효과와 임상적 고찰
이택근 ( Taek Geun Lee ),황보현 ( Hyun Hwangbo ),이숙경 ( Sook Kyung Lee ) 대한피부과학회 2016 대한피부과학회지 Vol.54 No.8
Background: Although several traditional treatments have been applied for recalcitrant viral warts, these treatments have rarely resulted in complete recovery. To treat the recalcitrant viral wart, alternative therapies are required. Objective: This study aimed to evaluate the efficacy and safety of quadrivalent HPV vaccine for recalcitrant wart treatment. Methods: From 2012 to 2014, 17 patients who provided informed consent were enrolled. All patients received 3 doses of quadrivalent HPV vaccine at 0, 2, and 6 months, respectively. During clinic visits, doctors checked the grade of improvement, patient satisfaction, and treatment side effects. After completion of the 3 doses, the patients were followed up for 5 months with outpatient visits and telephone inquiries. Results: After the third dose, 58.8% of patients showed complete remission and 41.2% showed no response after 5 months. There were no statistically significant differences in sex, age, disease duration, number, anatomic site, and previous treatment between the complete remission group and the no-response group. An adverse effect (syncope) was observed in one patient. Conclusion: Compared with traditional aggressive therapies, quadrivalent HPV vaccine is a simple method and does not usually interfere with the patient’s work or social life. Quadrivalent HPV vaccine is an effective and safe alternative treatment for recalcitrant warts. (Korean J Dermatol 2016;54(8):614∼621)
황보현 ( Hyun Hwangbo ),이택근 ( Taek Geun Lee ),정세원 ( Se Won Jung ),손현호 ( Hyun Ho Son ),이숙경 ( Sook Kyung Lee ) 대한피부과학회 2015 대한피부과학회지 Vol.53 No.7
Squamous cell carcinoma commonly originates from recalcitrant wound sites, including burn scars, pressure sores, stasis ulcers, osteomyelitis, and sites of frostbite. A 62-year-old male was referred to the dermatology department for skin necrosis of his right great toe and walking difficulty. He had a history of smoking, drinking alcohol, and frostbite of his right great toe 9 years prior, which deteriorated into osteomyelitis due to poor care. Although a skin biopsy was recommended before amputation, the two procedures were performed simultaneously due to a lack of toe function due to severe osteolysis. Biopsy of the amputated toe tip showed many lobules consisting of atypical keratinocytes with hyperchromatic nuclei, and severe dermal pleomorphism. After evaluation for distant metastasis, including a (99m) Tc-MDP bone scan, 18F-FDG positron emission tomography scan, computed tomography, and ultrasound, no metastasis was detected. (Korean J Dermatol 2015;53(7):556∼559)
황보현 ( Hyun Hwang Bo ),이택근 ( Taek Geun Lee ),정세원 ( Se Won Jung ),이숙경 ( Sook Kyung Lee ) 대한피부과학회 2014 대한피부과학회지 Vol.52 No.9
Eccrine syringofibroadenoma (ESFA) is a rare, benign adnexal neoplasm of eccrine differentiation. It is typically located on the limbs and presents as a plaque or a solitary hyperkeratotic nodule in an adult. However, there are several clinical subtypes, ranging from a solitary papule or nodule to multiple lesions with linear or diffuse distribution. Despite the diverse clinical presentation, ESFA is histologically similar. It commonly shows proliferation of anastomosing cords and strands of cuboidal epithelial cells with or without lumina embedded in a fibrovascular stroma. Herein, we report an unusual case of ESFA with verrucous surfaced plaque present on the scalp since birth in a 22-year-old man. (Korean J Dermatol 2014;52(9):654∼657)
Self-healing Juvenile Cutaneous Mucinosis 1예
문승현 ( Seung Hyun Moon ),정우석 ( Woo Seok Jeong ),이택근 ( Taek Geun Lee ),권태광 ( Tae Gwang Kwon ),이숙경 ( Sook Kyung Lee ) 대한피부과학회 2016 大韓皮膚科學會誌 Vol.54 No.10
Self-healing juvenile cutaneous mucinosis (SHJCM) is a rare disorder of unknown origin that affects healthy children. It is characterized by multiplication of transient papules and nodules on the head and periarticular area. Histopathologically, lesions show mucin deposition in the dermis or subcutis. A 9-year-old male patient presented with multiple skin-colored papules and nodules on the face and both hands. These papules and nodules had appeared over the preceding months and had been increasing in number. He was otherwise healthy and had no underlying systemic disorders. Skin biopsy in the right thenar nodule revealed deposition of amorphous material stained positively with Alcian blue (pH 2.5) within the dermis and subcutis. Spontaneous resolution occurred over several months without sequelae. (Korean J Dermatol 2016;54(10):814∼818)
문승현 ( Seung Hyun Moon ),진우정 ( Woo Jung Jin ),정우석 ( Woo Seok Jeong ),이택근 ( Taek Geun Lee ),이숙경 ( Sook Kyung Lee ) 대한피부과학회 2018 大韓皮膚科學會誌 Vol.56 No.8
Wells’ syndrome or eosinophilic cellulitis is usually observed in adults who present with pruritic, erythematous and edematous plaques associated with papules or vesicles. It is a rare inflammatory dermatosis of unknown etiology showing an eosinophil-mediated immune response. Classical histopathological features observed in patients are eosinophil-predominant inflammatory infiltration and marked dermal edema, along with ‘flame figures’. An 11-year-old boy presented with edematous plaques surmounted by vesicles on his abdomen and lower extremities. A month prior to presentation, these skin lesions occurred on other parts of his abdomen; however, they resolved spontaneously within a week. Skin biopsies from the recurrent lesions showed features consistent with Wells’ syndrome and a few molluscum bodies in the epidermis. Laboratory tests showed peripheral eosinophilia. We concluded that Wells’ syndrome in this young patient was caused by preceding molluscum contagiosum infection. (Korean J Dermatol 2018;56(8):499∼503)
안성훈(Sung Hoon Ahn),박승국(Seung Kook Park),허정욱(Jung Wook Hur),박성배(Seong Bae Park),허준영(Joon Young Huh),이택근(Taek Geun Lee) 대한소화기학회 1984 대한소화기학회지 Vol.16 No.1
Eosinophilic gastroenteritis is an uncommon disease charaterized by abdominal pain, vomiting, diarrhea, eosinophilia in peripheral blood and eosinophilic infiltration of gut. We experienced a case of eosinophilic gastroenteritis, which developed after ingestion of medicinal plant, Acanthopanax sessili florum, reported with review of literature.