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구조활성상관(QSAR)에 의한 피마엽 추출물의 HIV-1 효소억제활성인자 예측
한창호,유영법,Han, Chang-Ho,Yu, Young-Beob 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.4
Objectives : For the purpose of developing new anti-HIV agents from natural sources, the extracts of Ricinus communis were tested for their inhibitory effects on essential enzymes reverse transcriptase (RT), protease and alpha-glucosidase. Inhibition activity of major compounds of Ricinus communis were predicted from quantitative structure activity relationships (QSAR) in silico. Methods and Results : In the anti-HIV-1 RT using enzyme-linked oligonucleotide sorbent assay (ELOSA) method, water and methanol extracts (100ug/ml) of Ricinus communis showed strong activity of 94.2% and 82.7%, respectively. In the HIV-1 protease and alpha-glucosidase inhibition assay, neither water nor methanol extracts of Ricinus communis inhibited the activity of the enzyme to cleave any substrates as oligopeptides and oligosaccharides. Conclusions : We found that for these samples it is possible that the inhibition of the RT in vitro is due to the secondary metabolites of Ricinus communis such as ricinine and quercetin. It would beof great interest to identify the compounds which are responsible for this inhibition, since all therapeutically useful agents up to date are RT inhibitors.
한창대 한국화학공학회 1972 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.10 No.3
A first attempt is presented at investigating the problems of the automatic control of a diammonium phosphate granulation plant. This system is chosen for its simplicity, requiring one solid and one liquid feed stream to the granulator. A dynamic model is developed for the granulator in the form of a set of nonlinear differential equations in the zeroth, first and second moments of the granulator discharge stream particle size distribution. The equations are linearized and it is shown that the responses to similar disturbances of both the nonlinear and linear systems agree closely. Using the linear form, the model is extended to include the entire plant and a feed forward controller is designed by which disturbances in feed rate are used for manipulating the product recycle ratio to maintain constant the average particle size of granulator product.
초임계유체를 이용한 고삼으로부터 Genistein의 추출
한창남 ( Chang Nam Han ),강춘형 ( Choon Hyoung Kang ) 한국화학공학회 2015 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.53 No.4
본 연구에서는 초임계 이산화탄소를 용매로 사용하여 고삼으로부터 genistein을 추출하였다. 공용매와 추출 온도 및 압력 등에 따른 추출효율을 측정하였으며, 공용매로 메탄올과 에탄올을 사용하여 200 bar에서 300 bar의 압력범위와 35℃와 50℃의 온도범위에서 연구를 수행하였다. 조건에 따라 서로 다른 genistein의 추출효율을 보였으며, 특히 높은 압력과 높은 온도에서 가장 높은 추출효율이 관찰되었다. 또한 메탄올이 에탄올보다 더욱 효과적인 공용매 특성을 보였으며 농도가 높을수록 추출효율도 증가하였다. DPPH 라디칼 소거 활성을 측정하여 고삼 추출물의 항산화 활성을 비교하였다. This study was directed to finding an optimum extraction condition of genistein from the S. flavescens with supercritical carbon dioxide as a solvent. In this effort, effects of the extraction conditions including pressure, temperature and a co-solvent on the extraction efficiency were investigated. The aqueous ethanol and methanol solutions were used as co-solvents while the tested operating pressure and temperature ranges were from 200 bar to 300 bar and from 308.15 K to 323.15 K, respectively. The concentration of genistein was determined by means of HPLC equipped with a UV detector. From the results, it was observed that an increase in pressure led to the higher extraction efficiency. Further, methanol showed better performance as a co-slovent than ethanol. The DPPH radical scavenging activities were measured to compare antioxidant activities of S. flavescens extracts.
단일 롤 방법으로 제작한 3원계 Al-Cr-Si 급냉리본의 구조 및 열 특성
한창석,김기웅,김우석 한국재료학회 2021 한국재료학회지 Vol.31 No.5
Al-Cr-Si ternary quench ribbons are fabricated using a single roll method and investigated for their structural and thermal properties. In particular, the sinterability is examined by pulse current sintering to obtain the following results. The Al74Cr20Si6 composition becomes a quasicrystalline single phase; by reducing the amount of Cr, it becomes a twophase mixed structure of Al phase and quasicrystalline phase. As a result of sintering of Al74Cr20Si6, Al77Cr13Si10 and Al90Cr6Si4 compositions, the sintering density is increased with the large amount of Al phase; the sintering density is the highest in Al90Cr6Si4 composition. In addition, as a result of investigating the effects of sintering temperature and pressurization on the sintered density of Al90Cr6Si4, a sintered compact of 99% or more at 513 K and 500 MPa is produced. In particular, since the Al-Cr-Si ternary crystal is more thermally stable than the Al-Cr binary quaternary crystal, it is possible to increase the sintering temperature by about 100 K. Therefore, using an alloy of Al90Cr6Si4 composition, a sintered compact having a sintered density of 99 % or more at 613 K and 250 MPa can be manufactured. It is possible to increase the sintering temperature by using the alloy system as a ternary system. As a result, it is possible to produce a sintered body with higher density than that possible using the binary system, and at half the pressure compared with the conventional Al-Cr binary system.
복합운동의 운동유형 순서변화가 비만여성에게 미치는 영향
한창수(Han, Chang-Soo),이규승(Lee, Gyu-Seung),이무식(Lee, Moo-Sik),나백주(Na, Bak-Ju),황혜정(Hwang, Hye-Jeong) 한국산학기술학회 2009 한국산학기술학회 학술대회 Vol.- No.-
본 연구는 복합운동 유형 순서 변화에 따른 생리적, 생화학적 변화를 비교 하고자 40대 비만여성을 대상으로 12주간 복합운동을 실시하였다. 복합운동 유형은 유산소성 운동과 저항성 운동그룹 그리고 저항성 운동과 유산소성 운동그룹으로 구성하였다. 체지방량의 경우 A그룹의 평균변화량이 B그룹 평균변화량보다 더 많이 감소하였고 통계적으로 유의한 차이를 보였다(p<0.01). 혈당의 경우는 A그룹보다는 B그룹이 더 많이 감소하였으며 통계적으로 유의한 차이를 보였다(p<0.01). 따라서, 비만 중년 여성의 체중감량을 위한 신체구성 변화 유도를 위해서는 복합운동의 순서 변화에 따른 운동유형이 선택적으로 사용되어질 수 있다.