Iopamidol과 Ioversol 제제 조영제의 온도변화에 따른 물리화학적 분석

한범희 대한방사선과학회 2020 방사선기술과학 Vol.43 No.4

In this study, the P contrast agent of Iopamidol, which is a nonionic iodide contrast agent most commonly used as a vascular contrast agent in medical institutions, and the O contrast agent of Ioversol, were studied. The physicochemical changes according to the temperature change were compared and analyzed using the Bruker Avance 500MHz Nuclear Magnetic Resonance Spectrometer owned by the Korea Basic Science Institute (KBSI). There was no physical or chemical change in the O contrast medium of Ioversol formulation in temperature change. However, in the P contrast agent of Iopamidol, a doublet peak began to appear in the 1.1 ppm region of the sample at 60℃, and the doublet peak was clearly observed in the sample at 80℃. As a result of this study, 1H-NMR analysis revealed that the P contrast agent of the Iopamidol formulation was dissociated from chemical bonds as it rose to a high temperature of 60℃ or higher, resulting in the formation of foreign substances. It was evaluated that the O contrast agent of Ioversol formulation had physico-chemical stability than the P contrast agent of Iopamidol formulation. As shown in this study, it is necessary to analyze the physical and chemical changes of contrast agents according to various environmental factors.

DNA GLYCOSYLASE IN BACILLUS SUBTILIS WHICH RELEASES PRIMARILY 3 - METHYLADENINE

한범희,고용송,양철학 한국생화학분자생물학회 (구 한국생화학회) 1987 추계학술대회집 Vol.- No.-

진단용 X선 장치에서 방사선출력의 재현성 평가 (IEC 60601-2-54 표준규격을 기반으로)

한범희,정홍량,임청환,김종일,이상호,한상현,홍동희,김창규,유인규,모은희 한국디지털정책학회 2014 디지털융복합연구 Vol.12 No.2

Iopamidol과 Ioversol 제제 조영제의 사용 후 보관 기간에 따른 ¹H-NMR 분석

한범희(Beom-Hee Han) 대한방사선과학회(구 대한방사선기술학회) 2021 방사선기술과학 Vol.44 No.3

Since the side effects of contrast agents occur in many ways, hospitals must clearly identify the contrast agents and know how to manage them. Storage of contrast media It is common practice to store contrast media in a warm room to reduce viscosity and improve patient comfort. However, it is important to recognize that long-term storage at high temperatures can shorten the shelf life of a product. Therefore, in this study, the presence or absence of chemical changes according to the storage period after using the contrast medium was analyzed. As the analysis equipment, a 500 MHz Nuclear Magnetic Resonance Spectrometer of Bruker Avance (Germany) possessed by Korea Basic Science Institute (KOREA BASIC SCIENCE INSTITUTE; KBSI) was used. For the X-ray iodide contrast medium, Pamiray contrast medium of Iopamidol and Optiray contrast medium of Ioversol, samples remaining after 7 days, 20 days, 30 days, and 1 year were collected, By acquiring the spectrum from the 1H-NMR spectrometer of the contrast medium stimulated by It was compared and analyzed with the standard sample. In conclusion, depending on the storage period of the contrast medium, no peaks of physical and chemical changes were observed in both the Pamiray contrast medium of Iopamidol and the Optiray contrast medium of Ioversol after 7 days, 20 days, 30 days, and 1 year after use.

진단용 DR 발생장치에서 IEC 표준규격과 상용부하의 공기커마 직선성에 대한 일관성 비교

한범희(Beomhui Han),김종일(Chongyeal Kim),이상호(Sangho Lee),한상현(Sanghyun Han),유인규(Ingyu You) 한국방사선학회 2012 한국방사선학회 논문지 Vol.6 No.5

본 연구에서는 IEC 60601-2-54에서 제시한 표준을 근거로 부하조건에서의 제한된 간격으로 걸친 공기커마를 절대측정하여 X선의 직선성을 면밀히 평가하여 다음과 같은 결과를 얻었다. 10대를 대상으로 한 모든 진단용 X선 발생장치(DR)는 IEC 60601-2-54 표준에서 제시한 공기커마의 직선성이 부적합으로 나타났고, 일반적인 조사선량의 직선성 평가방법에서는 4대에서 최고 관전압의 50%와 80%의 두 개 측정 계열 모두 부적합으로 나타났으며, 나머지 6대에서는 최고 관전압의 50%와 80%의 두 개 측정 계열 모두에서 적합으로 나타났다. IEC 60601-2-54 표준에서 제시한 직선성 시험과 기존의 조사선량 직선성 시험이 많은 차이를 보였다. IEC 60601-2-54 표준+에서 제시한 공기커마의 직선성은 국제표준의 권고사항이므로 기존의 조사선량 직선성 보다 상당히 타당성이 있고, 방사선량을 정량화하기 위한 표준으로 IEC 60601-2-54 표준에서 제시한 공기커마의 직선성이 진단용 X선 영상장치 성능관리에 중요한 평가 요소라 사료된다. In this study, based on IEC 60601-2-54 standard load conditions presented in the limited interval over the air kerma at the absolute linearity closely evaluated by measuring the X-ray results were as follows: 10 units targeted all Diagnostic X-ray generating device (DR) presented in the IEC 60601-2-54 standard linearity of air kerma emerged as inappropriate, the general evaluation of the dose linearity from four in the top 50% and 80 kVp % of the two measurement series were as irrelevant all the rest from six of the top tube voltage of 50% and 80% of the two measurement series, appeared in all suitable. Presented in IEC 60601-2-54 standard dose linearity testing and conventional linearity tests showed many differences. IEC 60601-2-54 standard linearity in the proposed international standards of air kerma is the recommendation of the existing dose linearity considerably more feasible, and to quantify the amount of radiation as the standard suggested by the standard IEC 60601-2-54 air kerma of a diagnostic X-ray imaging device linearity performance management is considered key elements in the critical appraisal.

이동건강검진차량에서 외부의 누설선량 측정

한범희(Beom-Hee Han),한상현(Sang-Hyun Han),모은희(Eun-Hee Mo),김종일(Chong-Yeal Kim) 한국콘텐츠학회 2015 한국콘텐츠학회논문지 Vol.15 No.3

이동건강 검진차량에서 검진을 받는 환자나 종사자들에 대한 피폭선량이 증가하고 있으나 차량 외부의 누설방사선량에 대한 조사는 아직도 미비하다 할 수 있다. 이에 본 연구에서 실험을 통한 결과는 다음과 같이 나타났다. 누설선량이 가장 많이 발생하는 곳은 출입문에서는 우측으로 1.14±1.75 mR/h, X선 발생기가 근접한 측면에서는 상부로 0.65±1.25 mR/h, X선 발생기와 떨어진 측면에서는 하부로 0.91±1.25 mR/h, 검출기가 인접한 후면에서는 상부가 96.98±158.88 mR/h으로 다양한 위치에서 누설선량이 나타났다. 측정 위치별로는 검출기가 인접한 후면에서 67.48±97.03 mR/h으로 누설선량이 가장 높았다. 진단용 방사선 발생장치의 안전관리에 관한 규정에는 주당 최대누설선량이 모두 만족하였지만 후면에서의 누설선량은 시간당으로 표시될 때는 무시 못 할 누설선량이 측정되었다. 따라서 이동건강검진차량에서 외부의 누설선량은 우리가 간과해서 아니 되며 관심을 가지고 방사선 방어시설의 방어벽 누설선량 기준을 다시 평가하는 기회가 필요하며, 이동건강검진차량을 이용한 X선 촬영이 증가함에 따라 시간당 선량으로 적절한 기준을 정하기 위한 방안과 노력이 요구된다고 하겠다. Checked out by the moving vehicle health checks for patients, practitioners, and the increase in radiation dose outside the vehicle, but an investigation into the leakage of radiation can still be negligible. In this study, through experimental results were as follows: Dose that occurs most often where the leak in the right door 1.14±1.75 mR/h, X-ray generator in terms of proximity to the top 0.65±1.25 mR/h, X-ray generator and away to the bottom in terms 0.91±1.25 mR/h, the adjacent rear detector in the upper part 96.98±158.88 mR/h dose of the leak appeared in various locations. By measuring position from the rear of the adjacent detector 67.48±97.03 mR/h dose had the highest leakage into. Generating device for diagnosis of radiation safety regulations regarding the maximum leakage dose per week, but all met back when it is displayed in the leakage dose Hourly rates do not ignore the leakage radiation dose were measured. Therefore, a mobile health screening in a vehicle outside of the leakage radiation dose to the liver and move on we are not interested twelve barrier leakage radiation dose of defense has a chance to re-evaluate the standards required, and move the vehicle health check using the X-ray increases as the dose per hour, depending on the criteria for choosing the appropriate measures that will require effort.

건강검진차량에서 외부 누설방사선량 측정

한범희(Beom-Hee Han),정홍량(Hong-Ryang Jung) 한국콘텐츠학회 2011 한국콘텐츠학회 종합학술대회 논문집 Vol.9 No.1

¹H-NMR Spectroscopy를 이용한 Non-ionic Monomer 조영제의 화학적 구조 분석

한범희(Beom-Hee Han) 대한방사선과학회(구 대한방사선기술학회) 2021 방사선기술과학 Vol.44 No.4

Studies on the side effects of contrast agents are being discussed based on various cases, but studies analyzing the chemical structure of the underlying contrast agents are difficult to understand as the manufacturers have not disclosed them. Therefore, in this study, the chemical structure of the contrast medium was analyzed using 1H-NMR spectrometer for Omnipaque contrast medium prepared from Iohexol, which is a nonionic iodide contrast medium, Xenetix contrast medium from Iobitridol, and Iomeron contrast medium from Iomeprol. As a result, it was found that the Omnipaque contrast medium of Iohexol had 6 carboxyl groups, 3 carbonyl groups, 4 amine groups, 1 methyl group, and 2 cyano groups. It was found that the Xenetix contrast medium of the iobitridol formulation had 6 carboxyl groups, 3 carbonyl groups, 2 amine groups, and 4 cyano groups. It was found that the Iomeron contrast agent of the Iomeprol formulation had 5 carboxyl groups, 3 carbonyl groups, 4 amine groups, 1 methyl group, and 2 cyano groups. As shown in this study, the chemical structure of the non-ionic monomer contrast agent increases its affinity with water by binding a number of hydroxyl groups (OH) to the carboxyl group. It is necessary to accurately identify each of these factors and analyze the physical and chemical changes of the contrast medium according to various environmental factors.

DXA측정기 종류에 따른 요추부와 대퇴경부 골밀도 값의 측정오차 비교

한범희(Beom-Hee Han),정홍량(Hong-Ryang Jung),임청환(Cheong-Hwan Lim),이혜남(Hye-Nam Lee),정천수(Cheon-Soo Jeong),이상호(Sang-Ho Lee) 한국콘텐츠학회 2010 한국콘텐츠학회논문지 Vol.10 No.3

본 연구는 골밀도측정기 Norland와 Osteocore, Lunar 세 기종을 이용하여 각각 100명씩 총 300명을 대상으로 신체특징 중 연령, 신장, 체중으로 구분하여 측정오차를 비교분석하였으며, 요추부와 대퇴경부를 각각 정상(T-score?-1.0), 골감소증(-1.0>T-score>-2.5), 골다공증(T-score?-2.5)으로 분류하여 각각의 그룹에서 측정오차를 비교분석하여 다음과 같은 결론을 얻었다. 연령과 신장에서 Norland측정기가 측정오차의 변화가 가장 적었으며, 체중에서는 Lunar측정기가 측정오차의 변화가 가장 적은 것으로 나타났다. 또한, 요추부를 기준으로 골밀도 측정오차를 비교한 결과 Lunar, Norland, Osteocore 세 기종 모두 골감소증에서 측정오차의 변화가 가장 적은 것으로 나타났고, 대퇴경부를 기준으로 골밀도 측정오차를 비교한 결과 Lunar, Norland, Osteocore 세 기종 모두 골다공증에서 측정 오차의 변화가 가장 적은 것으로 나타났다. 각 변수에 있어서 기종 마다 측정오차가 다르게 나타났으며, 이를 해결하기 위해서는 표준화된 공통 Phantom을 사용하여 각 회사의 측정치를 환산 비교하고, 소프트웨어의 교체에 따른 상호보정이 필요할 것으로 사료된다. In this study, three different devices, Norland, Osteocore and Lunar were used to compare and analyze the measurement error by each bone density measurement device by classifying the physical characteristics into age, height and weight, the subject of total 300 sampling 100 persons for each device. Categorizing Lumbar region and Femoral neck as normal (T-score?-1.0), osteopenia (-1.0>T-score>-2.5) and osteoporosis (T-score?-2.5), the findings were observed as follows. Norland device showed the least measurement error in age and height, while Lunar showed the least in weight among the devices. And, the result of comparing the bone density measurement error based on the lumbar region showed that all of Lunar, Norland and Osteocore have the least variation of measurement error in osteopenia and the result of comparing based on the femoral neck showed that all of Lunar, Norland and Osteocore have the least variation of measurement error in osteoporosis. For each variable, the measurement error was observed to be vary upon the device. To solve this, standardized common Phantom should be used to compare and converge the measured value of each company and cross-calibration would be necessary when replacing the software.

폐경 후 여성에서 골밀도와 심혈관위험인자의 관련성에 대한 연구

한범희(Beom-Hee Han),정홍량(Hong-Ryang Jung) 한국콘텐츠학회 2009 한국콘텐츠학회논문지 Vol.9 No.10

본 연구는 골밀도검사를 받은 폐경 후 여성들을 대상으로 신체특징을 조사한 다음 혈압측정과 혈액검사를 실시하였으며, 총 653명을 대상으로 하였다. 통계 분석은 SPSS for Windows 프로그램(version 12.0)을 사용하였고, ANOVA 및 카이제곱으로 관련성을 비교분석하였으며, 변인 예측을 위해 선형회귀분석방법을 실시하여 다음과 같은 결론을 얻었다. 골밀도와 심혈관위험인자 중 신장, 체중, 체질량지수는 T-score와 유의한 양의 관계가 나타났고(p<0.001), 연령, 수축기혈압, 이완기혈압, 총콜레스테롤, 고밀도지단백콜레스테롤, 중성지방, 혈당에서 T-score와 유의한 음의 관계가 있는 것으로 나타났으며(p<0.001), 골밀도에 가장 큰 영향을 미치는 변인은 체중(18.7%)으로 나타났다. 골밀도와 심혈관위험인자의 관계는 모두에서 유의한 관련성이 나타났다. 따라서 인구의 노령화와 함께 여성들에게서 골다공증 문제가 더욱 중요시되고 있는 추세이므로 골다공증의 발생기전을 규명하고 효율적인 예방 전략을 수립하기 위한 체계적인 연구의 시도가 계속되어야 할 것으로 사료된다. The study surveyed 653 people who have been blood pressure measuring and body feature in postmenopausal women received BMD test, The statistical analysis was done using the SPSS 12.0 for windows and the study using comparison analyzed at ANOVA, X 2. linear regression analysis, the following conclusions were made. As a result of analyzing the relationship between BMD and Cardiovascular Risk Factor were found to be a positive significant component(p<0.001) height, weight, BMI. After the analyses of the age, systolic blood pressure, diastolic blood pressure, total cholesterol, high density lipoprotein cholesterol, triglyceride and glucose were shown to be a negative significant component(p<0.001). Weight was the one that was mostly affected BMD(18.7%). As a result of analyzing the relationship between BMD and Cardiovascular Risk Factor had a significant component at all. According to the problem with osteoporosis in women is becoming a major issue in society, The study is considered to be tried to make phased and, better organized to establish preventive strategies and warranted causes of osteoporosis.