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- 저자 : 한능희(Neung Hee Han) (검색결과 4 건)
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백서에서 제 5 , 6 번 요추신경의 결찰에 의하여 유발된 작열통성 통증에 대한 Ketamine의 치료효과
이원형(Won Hyung Lee),한능희(Neung Hee Han),김태헌 대한통증학회 1995 The Korean Journal of Pain Vol.8 No.1
N/A We produced the causalgiform pain by the tight ligation of L5 and L6 spinal nerves in the adult rats. To evalute the effect of ketamine noncompetitive NMDA(N-methyl-D aspartate) antagoinst on the causalgiform pain, we tested the changes of; withdrawal sensitivity to the innocuous mechanical stimulation of Von Frey hair 2.35 g(mechanical allodyniag withdrawal frequency to the cold stimulation of acetone(cold allodynia); and total withdrawal time(second) to the cold(4 ℃) plate stimulation(cold hyperalgesia) after the administration of I mg, 3 mg, 10 mg/kg ketamine. The results were as follows.' 1) Cold hyperalgesia was significantly reduced(p<0.05) by 1 mg, 3 mg, 10 mg/kg ketamine. 2) Cold allodynia and mechanical allodynia was significantly reduced(p<0.05) by l0mg/kg keiamine. Above results suggest a therapeutic utility of ketamine in treatment of causalgia especial- ly, cold hyperalgesia.
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개왕절개술을 위한 마취유도시 Propofol 과 Thiopental 의 비교
배진호,최세진,한능희,손수창 대한마취과학회 1992 Korean Journal of Anesthesiology Vol.25 No.2
Thiopental sodium has been used in anesthesia of Caesarean section since 1936 and is regarded as the standard induction agent. Propofol has properties which suggest that it might be a useful alternative to thiopental. We compared propofol with thiopental for induction of anesthesia in elective Caesarean section in the present study. Particular attentaion was paid to induction characterisitics and the neonatal effects of both agents. The results were as follows. 1) Side effect during induction were rare in both groups. But both agents caused mild discomfort on injection. 2) There were significant increase in systemic arterial pressure, diastoric pressure and heart rate at postintubation I minute in both groups. But there were no significant differences in cardio vascular response between both groups during the induction. 3) The Apgar scores of the neonates did not differ significantly, and the blood gas analyses of neonates were within the normal range in both groups. We conclude that propofol, in a dose of 2.5 mg/kg, is an acceptable alternative to thiopental for the induction of general anesthesia in Caesarean section.
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Midazolam 의 중추신경계에 미치는 영향과 Flumazenil 의 길항작용에 대한 연구
김문호,이정은,최세진,한능희,손수창 대한마취과학회 1991 Korean Journal of Anesthesiology Vol.24 No.2
The effects of midazolam and diazepam which were used as an induction agent of general anesthesia were evaluated. And flumazenil which is a potent competitive inhibitor of the specific binding of benzodiazepines at the receptor level was evaluated too. Sixty patients were divided into three groups as follows: Group I (n=20); Midazolam (average 0.24 mgkg-1) was administered as an induction agent and flumazenil (average 0.24 mgkg-1) was administered in recovery room Group II (n=20); Diazepam (average 0.35 mgkg-1) was administered as an induction agent and flumaxenil (average 0.25 mgkg-1) was administered in recovery room Group III (n=20); Midazolam (average 0.24 mgkg-1) was administered as an induction agent and normal saline was administered in recovery room instead of flumaxenil The result were as follows: 1) Systolic and diastolic blood pressure and heart rate were not changed significantly, except diastolic blood pressure decreased significantly (p$lt;0.05) in group II, after intravenous administration of midazolam and diazepam. But these were all increased significantly (p$lt;0.001) after endotracheal intubation in all groups. 2) Systolic and diastolic blood preasure and heart rate were not changed significantly after intravenous administration of flumazenil in group I, II and there were no significant differences between each groups. 3) Tidal volume was increased significantly (p$lt;0.05) in group 1 from 15 min after administration of flumazenil. There were no significant changes in all groups in respiratory rate. SaO₂ was increased significantly (p$lt;0.05, p$lt;0.001) in group I, II from 5 min after administration of flumazenil. But it was increased significantly (p$lt;0.05) in group III from 20 min after administration of normal saline too. EtCO₂ was decreased insignificantly in all groups. 4) Recovery from anesthesia according to Modified Steward Coma Scale was much improved immediately after administration of flumazenil and was significant (p$lt;0.001) statistically in group I, II from 5 min after administration of flumazenil and reached complete recovery from 20 min after administration of flumaxenil. It was increased gradually and become significant in group III from 10 min after administration of normal saline. These changes of group I, II were significant (p$lt;0.05) compared with group III and reached complete recovery from 60 min after administration of flumazenil.
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백서 신경장해성 통증시 Dynorphin, Enkephalin, c-Fos 유전자 발현에 관한 연구
김혜자,이원형,신용섭,최세진,한능희,임규,황병두,손수창,황원재,윤석화 대한마취과학회 1996 Korean Journal of Anesthesiology Vol.31 No.3
Background: We studied the time course of gene expression of dynorphin, enkephalin, c-fos, and the changes of allodynia, and the effect of chemical sympathectomy on the gene expression and allodynia in neuropathic rat. Methods: In two groups of rat (Sprague-Dawley), the left L5 and L6 spinal nerves were tight ligated. In gene expression group (N=25), behavioral tests for mechanical allodynia and cold allodynia were perfomed for the next two weeks. After the test of allodynia, the expression of dynorphin, enkephalin, c-fos were assessed by Northern blot hybridization. In chemical sympathectomy group (N=16), after chemical sympathectomy (guanethidine 70 mg/kg intraperitoneally, from postoperative 7 days to 9 days), the changes of allodynia and the gene expression of enkephalin, c-fos were tested. Results: Mechanical allodynia and cold allodynia was developed on the postoperative 3, 5, 7, 14 days. Preprodynorphin mRNA expression was reached peak level at the postoperative 8 hrs, sustained increase by the postoperative 3 days, but preproenkephalin mRNA expression increased slightly after operation. c-Fos mRNA expression was increased immediately at the postoperative 30 min, 1 hr, returned to normal level thereafter, and increased again on the postoperative 3, 5, 7 days that neuropathic pain was developed. Mechanical allodynia and cold allodynia were decreased by chemical sympathectomy. The increased c-fos mRNA expression and pain at postoperative 7 days was reduced by chemical sympathectomy. Conclusion: These results suggest that the transient gene expression of dynorphin and c-fos after tight ligation of L5 and L6 spinal nerves induces the development neuropathic pain, and late c-fos expression is related to neuropathic pain.
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