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Other up-to-date treatment modalities of vitiligo
최종원 ( Chong Won Choi ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
Vitiligo is an acquired depigmenting disorder that occurs in about 1% of the population. The white macules and patches in vitiligo patients are the consequence of melanocyte destruction in the skin and they can be an emotional stress on the vitiligo patients. The immune modulating agents (systemic/topical steroids, topical calcineurin inhibitors) and phototherapy (narrow band UVB and excimer laser) are the mainstay of current modalities for the treatment of vitiligo. Despite the increased knowledge of pathogenesis and the enthusiastic use of above-mentioned treatment modalities, current management for vitiligo cannot ensure the complete cure. To overcome the limitation, diverse attempts have been tried and various results have been reported. Herein, I will talk about the up-to-date treatment modalities of vitiligo through a review of recently published papers. The talk will include the use of cytokines and its analogue (α-MSH analogue, afamelanotide), inhibitors for cell signaling pathways (Janus kinase inhibitor, tofacitinib), antibiotics (tetracycline and its derivative, minocycline), and lasers (CO<sup>2</sup> fractional laser) in the treatment of vitiligo. Recent clinical trials and the possible mechanism of each modality will be briefly reviewed.
허근,최종원,Huh, Keun,Choi, Chong-Won 대한약학회 1984 약학회지 Vol.28 No.1
After pretreatment with ginseng followed by induction of acute intoxication of alcohol, the activities of alcohol dehydrogenase (ADH), microsomal ethanol-oxidizing system (MEOS) and aldehyde dehydrogenase(Ald DH) increased respectively compared to the groups treated with alcohol alone. In case that ginseng was given to rats fed with 5% alcohol instead of water for 60 days, the activities of ADH and MEOS increased compared to the groups treated. On the contrary, the activity of Ald DH in mitochondrial fraction decreased to an extent of about 35% in chronic alcoholism, but after pretreatment of ginseng the activity was restored to the control level. On the other hand, the catalase activity was not significantly affected by either treatment. Ginseng butanol fraction significantly increased the serum isocitrate dehydrogenase activity which is inhibited by alcohol-treated in rat. Alcohol-induced lactate dehydrogenase activity was decreased to control level in liver by ginseng treatment. And the serum level of lactic acid also decreased by ginseng treatment in alcohol-intoxicated rat. Ginseng butanol fraction markedly decreased the xanthine oxidase activity in the ethanol-treated rat liver. It was also observed that ginseng reduced the blood concentration of uric acid on experimentally reduced hyperuricemia by alcohol treatment. Uricase activity was not affected by either treatment. Ginseng butanol fraction decreased the hepatic aniline hydroxylase activity which was induced by alcohol-treated rat. These results suggest that the treatment with ginseng can be promoted the recovery from alcohol intoxication and some therapeutic effect on alcoholinduced metabolic disease.
인삼 성분이 Ethanol의 장관내 흡수에 미치는 영향
허근,최종원,Huh, Keun,Choi, Chong-Won 대한약학회 1983 약학회지 Vol.27 No.2
The effect of ginseng butanol fraction (total sponin) on the absorption rate of ethanol in rat intestine was examined. Ginseng butanol fraction showed inhibitory effect on the intestinal absorption of ethanol in situ as well as in vitro test. Ginseng butanol fraction markedly decreased the ethanol blood level, delayed onset time of ethanol effect and shortened sleeping time when it was adminstered orally together with ethanol. These results suggest that ginseng may alter the ethanol blood level by decreasing the intestinal absorption of ethanol.
Alcohol 투여한 Xanthine Oxidase 활성에 미치는 인삼의 영향
허근(Keun Huh),최종원(Chong-Won Choi) 한국생약학회 1980 생약학회지 Vol.11 No.1
본 교실에서는 인삼추출물이 alcohol및 alcohol의 대사산물이며 독성이 강한 acetaldehyde를 처리하는 과정에 관여하는 효소의 활성을 현저히 증가시키는 작용이 있음을 보고한 바 있다. 한편 alcohol투여로써 야기되는 뇨산의 혈중농도의 증가가 인삼추출물에 의하여 감소됨을 관찰하였다. 연자 등은 alcohol에 의하여 유도되어진 뇨산의 혈중농도 증가를 인삼 추출물이 어떠한 기전으로 조절하는 가를 검토하였다. 1) 급성 alcohol 중독으로 증가되었던 간장중의 xanthine oxidase의 활성이 인삼추출물의 투여로써 정상으로 되었다. 2) 만성 alcohol 중독에서도 증가되었던 본 효소의 활성이 인삼추출물의 투여로 정상으로 회복되었다. 3) 급성 및 만성으로 alcohol을 투여하여 증가되었던 X, O의 활성은 인삼추출물을 각각 8㎎/㎏ 및 10㎎/㎏ 투여로써 현저한 감소를 보였으며, 이는 allopurinol 10㎎/㎏의 효과와 유사하였다. 4) 본 효소의 활성을 알코올 투여로써 증가시킨 후 in vitro실험을 행하였던 바 in vivo에서와는 반대로 적은 량(0.025㎎/㎖)에서는 증가되었으며 많은 량(0.06㎎/㎖)에서는 억제의 상반된 효과를 관찰할 수 있었다.