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RISS 인기검색어
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- 저자 : 최석채(Suk Chae Choi) (검색결과 3 건)
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당뇨병 환자에서 자율신경병증과 교정한 QT 간격과의 관계
조정구(Chung Gu Cho),임동석(Dong Suk Lim),최석채(Suk Chae Choi),홍석욱(Seung Wook Hong),장근(Geun Jang),김동훈(Dong Hun Kim),김창일(Chang Il Kim),박옥규(Ock Kyu Park) 대한내과학회 1991 대한내과학회지 Vol.41 No.2
N/A A simple method for evaluating alterations in cardiac sympathetic innervation may be measurement of the QT interval. Ninety-nine diabetic patients were separated into 4 groups based on the presence and degree of cardiac autonomic neuropathy (CAN) with noninvasive cardiovascular reflexes and blood pressure responses. None of the patients had evidence of ischemic heart disease, arrhythmia, or electrolyte imbalance. The corrected QT interval (QTc) was determined at rest with Bazett's formula. As a group, diabetic patients with 4 abnormalities of cardiac autonomic function had a longer QTc interval than those with no evidence of CAN. Diabetic patients with > 1 abnormality had a prolonged QTc interval compared with the control group of 68 healthy nondiabetic subjects. The frequency of prolonged (>430 ms, normal+2SD) resting QTc intervals increased with the increased number of abnormalities (0, 1-3, ?4): 19, 33, and 49%, respectively, Thirty out of 35 (86%) patients with a QTc >430ms had evidence of CAN. However, 59% (43 out of 73) of the patients with CAN had a normal QTc interval. These data provide evidence of a relationship between the presence and severity of CAN and degree of QTc interval prolongation. Compared with cardiovascular reflexes and blood pressure tests for CAN, the QTc interval in the group of diabetic patients studied without evidence of heart or electrolyte imbalance was an insensitive but specific marker. An abnormal QTc interval may be an additional diagnostic tool for evaluating CAN in patients with diabetes mellitus.
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장거리 달리기 선수에서 횡문근융해와 생화학적 지표의 변화에 대한 연구
김태현,조지현,이영진,나용호,최석채,안선호,송주흥,최석준 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.5
Background: Exercise has almost always been intuitively considered beneficial, but although rewards greatly outweigh risks, exercise occasionally produces bad or even fatal outcomes such as acute renal failure or sudden death. Exertional rhabdomyolysis has been occasionally reported in adult patients following such strenuous activities as military basic training, weight lifting, and marathon running. The purpose of the present study was to investigate whether exertional rhabdomyolysis developed, and how exercise could influence biochemical markers of rhabdomyolysis during resting, exercise, and recovery period in long-distance runners. Methods: Twenty-four young long-distance runners who volunteered to participate in the study, trained with running over 200km every week for 2 to 3 years were studied. Levels of serum creatine kinase(CK), lactate dehydrogenase(LDH), asparatate amino-transferase (AST), and myoglobin, and urine myoglobin were measured at 24hr(pre-exercise period) before, immediately (post-exercise period), and at 24hr(recovery period) after 10km running. Ten long-distance runners who were randomly selected at 24hr after 10km running, including one complaining of calf pain, and age-matched nine young control students were subjected to bone scan with technetiun-99m methylene diphosphonate(99mTc-MDP) Results: Serum CK activities in pre-exercise period were higher than that of the upper normal range. Serum CK and LDH activities were significantly increased in post-exercise period compared with pre-exercise periad(p$lt;0.05), were not decreased to the level of post-exercise in recovery period. The level of serum myoglobin was increased and decreased significantly,(p$lt;O.05, p$lt;0.01, respectively) and urine myoglobin and serum AST activities were remained within nomal range in each period. The mean uptake count of 99mTc-MDP in both lower extremities of runners was significantly greater than that of the control group(p$lt;0.001), and had good correlation with the serurn CK activities of post-exercise, and recovery period(r=0.87 p$lt;0.001, r=0.8 p$lt;0.01, respectively). Conclusion: This study suggests that rhabdomyolysis in the well trained long-distance runners may be developed in low grade, but ongoing injuries during each running. For the diagnosis of rhabdomyolysis in the well trained long-distance runners, serum CK levels are thought to be the most useful marker, and the cut-off value of serum CK levels should be lowered less than usual five times of normal value. A quantitative measurements of 99mTc-MDP uptake with serum CK levels can be more helpful in making the diagnosis of rhabdomyolysis in the well trained long-distanc runners.
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