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최명석 대한흉부심장혈관외과학회 1990 Journal of Chest Surgery (J Chest Surg) Vol.23 No.6
Hamartoma had been considered as a congenital malformation of a tumerous lesion since the original description by Albrecht in 1904. Pulmonary hamartoma is able to classified as endobronchial and intrapulmonary hamartoma clinically, and is considered to benign mesenchymal neoplasms which originated in peribronchial connective tissue, and so called mesenchymoma by someone. We have experienced 3 cases intrapulmonary hamartoma which were discovered during routine chest film check up at all cases and are able to detailed histologic examination by electron microscopy at one case.
성인에서 발견된 선천선 식도 - 기관지루 수술 치험 -1예 보고-
최명석 대한흉부심장혈관외과학회 1990 Journal of Chest Surgery (J Chest Surg) Vol.23 No.5
Congenital bronchoesophageal fistula is a rare anomaly that can appear in adult life uncommonly. There was a largest review that include 100 cases in the literature. In our case, he was 48 years old male patient who admitted for chronic coughing and recurrent lobar pneumonia on the right lower lobe since 10 years old. We could confirmed the fistular preoperatively by barium swallow examination and performed division of the fistula. The patient’s postoperative course was unremarkable. According Braimbridge’s classification, it was belonged to the type II.
최명석 대한흉부심장혈관외과학회 1990 Journal of Chest Surgery (J Chest Surg) Vol.23 No.5
Primary choriocarcinoma of the lung is extremely rare and have been reported ten and several cases only in the literature. It is very difficult to confirm the "Pure primary pulmonary choriocarcinoma" clinically, so most cases that have been reported in the literature confirmed by autopsy and the prognosis is relatively poor compared with metastases. We experience one case of the primary pulmonary choriocarcinoma. She was 53 year old multiparous woman[4 \ulcorner0 \ulcorner2 \ulcorner0] who complain right chest pain for 4 years. On plain film and computerized tomogram of the thorax at admission, 2.5cmx3.5cmx5 cm sized, well demarcated ovoid mass was founded on the right middle lobe just below the parietal pleura and growing rapidly on plain film to 5cm x 6.5cm x 7cm after 15 days. We confirm the choriocarcinoma in the lung by percutaneous needle aspiration biopsy and strongly suspect primary after various examination for rule out metastases from the ovary or uterus. We perform middle lobe lobectomy because that can not confirm the primary or the metastases because there are not complete histological examination by bilateral ovariectomy and hysterectomy, and under the belief that extragestational or extragonadal primary choriocarcinoma is more resistant to the chemotherapy, and could be reduce the duration of hospitalization and the amount of chemotherapy used to achieve remission On 14th postoperative day, serum p-HCG level was returned to normal limit, and perform chemotherapy two times on 3rd and 5th week for prevention surgical traumatic hematogenous metastases or undetected microfocus, but the patient expire on 68th postoperative day due to intracerebral hemorrhage in the intracranial choriocarcinoma which strongly suspected surgical traumatic hematogenous metastases.etastases.
최명석,Ankush Gupta,서정화,S. Velmathi,James N. Wilson,Jong S. Park 대한화학회 2015 Bulletin of the Korean Chemical Society Vol.36 No.1
In this study, we report the efficient identification of proteins using (6-hydroxy-2-naphthyl)ethenyl pyridinium dyes (HNEPs). These dyes exhibited characteristic fluorescence responses, showing enhanced fluorescence with a red shift in the case of bovine serum albumin. The nature of the interaction between the dye and the protein was examined using a combination of various spectroscopic techniques. A time-dependent density functional theory analysis supported the strong environment-dependent fluorescence emission properties of the dyes. The current investigation clearly demonstrates that a selective optical response HNEPs can find potential usefulness as bio-sensing probes.
최명석,이상환 한국콘텐츠학회 2020 한국콘텐츠학회논문지 Vol.20 No.6
With the recent development of digital technology, the research paradigm is evolving towards data-driven. National management and utilization of research data is a key element not only to enhance research transparency and efficiency, but also to prepare for a data-driven society. Policies and infrastructure for sharing and utilization of research data from publicly-funded research are being actively promoted worldwide. In Korea, related regulations were recently revised to mandate to submit a data management plan (DMP) when proposing a national R&D project. In order to effectively implement the sustainable DMP system, researchers need various support. In addition, guidelines and implementation procedures are essential for management and utilization of research data at the national or institutional level. In this paper, we provide an overview of the data management plan, examine the current status and issues in Korea, and suggest a template and checklists of data management plan, and an implementation procedure at research institutes. 최근 디지털 기술의 발전으로 연구 패러다임이 데이터 중심으로 변화하고 있다. 연구데이터의 국가적 관리와 활용은 연구의 투명성과 효율성을 제고하고, 나아가 데이터 기반으로 급변하는 사회에 대비하기 위한 필수 요소이다. 주요 선진국에서는 공적 지원에 의해 수행된 연구에서 생산되는 연구데이터의 공유·활용을 위한 정책과 인프라 구축이 적극적으로 추진되고 있다. 국내에서도 2019년 국가연구개발과제 제안시 데이터 관리 계획을 제출하도록 관련 규정이 개정되었다. 데이터 관리 계획 제도가 효과적으로 실행되고 지속성을 유지하기 위해서는 연구자에게 다양한 지원 여건이 필요하다. 또한 데이터 관리 계획 가이드라인과 이행 절차는 국가 또는 기관 차원의 연구데이터 관리․활용을 위해 필수적이다. 이 연구에서는 데이터 관리 계획의 개요와 국내의 추진 현황 및 이슈를 살펴보고, 작성 가이드라인과 체크리스트, 적용프로세스, 그리고 연구기관에서의 이행 방안을 제시한다.