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        足部白癬茵의 韓方治療劑 開發을 위한 硏究

        최규동,권영규,Choi, Gyu-dong,Kwon Young kyu, Yeong-Gyu 대한한방안이비인후피부과학회 2000 한방안이비인후피부과학회지 Vol.13 No.1

        Minimum inhibitory concentration(MIC) of Sophorae Subprostratae Radix. Aconiti Radix, Hibisci Syriaci Cortex and those mixture. Phellodendri Cortex, Sophorae Radix, Torilis Fructuson on various species of the dermatophytes on Microsporium gypseum, Trichophytone rubrum and Epidermophytone floccosum were determined after 4 weeks of incubation at $25^{\circ}C$ in Sabouraud dextrose broth. The results were summarized as followes : 1. Antifungal effects of Phellodendri $Cortex\;{\cdot}Hibisci$ Syriaci Cortex and mixture of Sophorae Subprostratae Radix, Aconiti Radix, Hibisci Syriaci Cortex on T rubrum which is the most common organism of tinea pedis were more effective than that of the others. 2 These results suggested that herbal medicines such as Phellodendri $Cortex\;{\cdot}Hibisci$ Syriaci Cortex and mixture of Sophorae Subprostratae Radix, Aconiti Radix, Hibisci Syriaci Cortexse can be used to treat tinea pedis and to improve untoward effects associated with the administration of antifugual agents.

      • KCI등재

        帶狀疱疹 患者의 治驗3例 報告

        최규동,채병윤,Choi, Gyu-Dong,Chae, Bhung-Yoon 대한한방안이비인후피부과학회 1997 한방안이비인후피부과학회지 Vol.10 No.1

        an acute, unilateral, self-limited inflammatory disease of cerebral ganglia and the ganglia of posterior nerve roots and peripheral nerves in a segmented distribution, caused by the chickenpox virus, and characterized by groups of small vesicles in the cutaneous areas along the course of affected nerves, and associated with neuralgic pain. three case of herpes zoster has severe post herpetic neuralgia. these patients has been treated with westernmedicine. But they could not expect to improve condition. We exprienced three cases of herpes zoster that have a result of effect with oriental treatment and lazer threaphy.

      • KCI등재

        黃連, 秦皮, 秦皮散이 綠膿菌性 角膜炎에 미치는 效果에 관한 實驗的 硏究

        최규동,채병윤,Choi, Gyu-dong,Chae, Byung-yoon 대한한방안이비인후피부과학회 1999 한방안이비인후피부과학회지 Vol.12 No.1

        Coptidis Rhizoma, Fraxini Cortex, Jinpisan(秦皮散) have been as eye washes of inflammatory eye disease in the oriental medicine. Especially Jinpisan(秦皮散) has been used for the disease which is similar to Peudomonas aeruginisa keratitis. This research was attempted to investigate the effect of Coptidis Rhizoma, Fraxini Cortex, Jinpisan(秦皮散), on Peudoronas aeruginisa keratitis. Pseudomonas aeruginosa keratitis causes a deep rapid intense ulceration which often leads to perforation of the cornea within 48 hours. In this research, we induced keratits in the rabbits by inoculating Pesudomonas aeruginosa(9027) and observed the effect on the keratitis and the irritation against the external eye. Also we mesured the minimum inhibitory consentration(MIC) of Coptidis Rhizoma, Fraxini Cortex, Jinpisan(秦皮散) by agar diliution method and the anti-bacterial activites by disk method. The tested bacteria were as follows : a) Pseudomonas aeruginosa (9027), b) Streptococcus pneumoniae(6303), c) Staphylococcus epidermidis(12228), d) Staphylococcus aureus(6538P). The results were as follows ; 1. The groups which were applied eye washes of Fraxini Cortex, Jinpisan reavealed a significant effect, but the group applied eye wash of Coptidis Rhizoma reveaded no effect on Pseudomonas aeruginosa keratitis. 2. Applying eye washes of Coptidis Rhizoma, Fraxini Cortex, Jinisan revealed an irritation against external eyes. 3. Coptidis Rhizoma showed an anti-bacterial activity on Pseudomonas aeruginosa, Streptococcus pneumoniae, Staphylococcus epidermidis, Staphylucoccus aureus by agar diliution method 4. Coptidis Rhizoma showed an anti-bacterial activity on Pseudomonas aeruginosa, Streptococcus pneumoniae, Staphylococcus epidermidis, Staphylococcus aureus by disk method. 5. Fraxini Cortex showed an anti-bacterial activity on Pseudomonas aeruginosa, Streptococcus pneumoniae, Staphylococcus epidermidis, Staphylococcus aureus by agar diliution method 6. Fraxini Cortex showed an anti-bacterial activity on Pseudomonas aeruginosa, Sireptococcus pneumoniae, Staphylococcus epidermidis, Staphy1ococcus aureus by disk method. 7. Jinpisan showed an anti-bacterial activity on Pseudomonas aeruginosa, Streptococcus pneumoniae, Staphylococcus epidermidis, Staphylococcus aureus by agar diliution method. 8. Jinpisan showed an anti-bacterial activity on Pseudomonas aeruginosa, Streptococcus pneumoniae, Staphylococcus epidermidis, Staphylococcus aureus by disk method. According to the above results, Fraxini Cortex, Jinpisan(秦皮散) are recognized to have an effective treatment on the Pesudomonas aeruginosa keratitis, so this experiment is thought to be a basic ingredient in proving the effect of Fraxini Cortex, Jinpisan which is applied many in documents and clinical medicine. In the comparison of anti-bacterial activity and results of treatment on the Pesudomonas aeruginosa keratitis, Jinpisan(秦皮散) was more effective than Coptidis Rhizoma, Fraxini Cortex.

      • KCI등재

        장기요양노인병원에서 발생한 보라색 오줌 증후군 또는 Purple Urine Bag Syndrome 16예 보고 및 문헌 리뷰

        최규동(Gyu-Dong Choi),가혁(Hyuk Ga),박기호(Ki-Ho Park),유병익(Byung-Ik Yoo),김성민(Sung-Min Kim),강문철(Moon-Chul Kang),이은자(Eun-Jah Lee),박승태(Seung-Tae Park) 대한임상노인의학회 2007 대한임상노인의학회지 Vol.8 No.2

        연구배경: 1978년 란셋 잡지에 보라색 소변에 대한 보고가 최초로 있은 이래, 이 현상에 대한 생화학적, 미생물학적, 임상적 규명이 있었다. 보라색 소변은 환자나 환자 가족에게 불편하거나 걱정스러운 질병이다. 그러나 대개의 경우 환자의 건강에 실제적인 위험이 되는 경우는 거의 없다. 심지어 보라색 소변은 열심히 치료할 필요가 없다고 주장하는 사람도 있다. 이에 대조군 연구를 통하여 보라색 소변의 위험요인과 임상적인 의미(심각성)에 대하여 평가를 하고자 한다. 방법: 2007년 2월부터 4월 사이에 인천은혜병원에 입원하고 있는 381명의 환자들 중 도뇨관을 삽입하고 있는 65명을 대상으로 하였다. 이 65명은 65세 이하이거나 1개월 이하동안 도뇨관을 갖고있는 환자는 제외한 숫자이다. 대상 환자는 모두 실리콘제의 폴리카테터와 일회용 소변주머니를 사용하였고 카테터의 교환주기는 특별한 경우 외에는 1개월마다 교환하였다. 대상환자 중 16명이 보라색 소변을 보여, 멸균생리식염수로 방광세척을 한 뒤 카테터와 소변 주머니를 소독된 새 것으로 무균적으로 교환한 뒤 소변배양을 실시하였다. 관련 환자와 대조군의 비교항목들을 통계처리하여 통계적인 유의성을 확인하였으며, 변수의 분석은 신뢰도 95%로(P value 0.05) 카이스퀘어 가설검정과 만-휘트니 U검사를 실시하였다. 결과: 보라색 소변을 보였던 환자들의 나이 평균은 80세였고 전원이 와상상태의 할머니였다. 대상환자의 진단명 중 가장 많은 것은 치매였다. 평균 도뇨기간은 22개월 이었다. 보라색소변을 보인환자군은 보이지 않은 환자들 보다 평균 도뇨기간이 길었으며, 변비가 더 심하였고 변비치료용 좌약 사용빈도가 높았다. 대조군에서는 조사기간 전 1개월 이내에 항생제를 사용한 빈도가 약간 더 높았으나 통계적인 의미는 확실하지 않았다. 결론: 보라색소변은 장기요양노인병원에서 흔히 발생하는 문제이다. 이전 연구들에서 없었던 보라색 소변과 항생제사용과의 관련성 및 변비치료제로 bisacodyl 좌약사용과의 관련성, 소변 카테터의 삽입기간 등에 대한 정보를 추가하여 얻을 수 있었다. Background: Since the first report of purple urine bag syndrome (PUBS) by Barlow and Dickson in 1978, many researchers have tried to reveal the clinical and bacteriological background of this phenomenon. To the best of our knowledge, most of them were case or case series reports and only three were case-control studies which compared the clinical, biochemical, or bacteriological background between patients with and without PUBS. It is certain that PUBS is an uncomfortable or troubling issue for some patients and their families. However, most of the patients who presented with PUBS were, largely, asymptomatic and it is apparent that PUBS is not a disease per se, nor does it appear to represent any real danger to patient's health, and some authors go so far as to even advocate that it is unnecessary to treat PUBS-affected patients aggressively. In this case-control study, we reviewed risk factors and clinical significance of PUBS in geriatric wards. Methods: Of the 381 hospitalized patients in a hospital specialized in the long term care of the elderly handicapped (Incheon Eun-Hye Hospital, Incheon, Korea), 65 patients who featured urinary catheterization during the period from February 2007 and April 2007 were enrolled in this study. Subjects who were younger than 65 or catheterized duration was less than one month were excluded. The same types of silicone Foley balloon catheter and disposable plastic urine bag were used for all patients. Routine Foley catheter change interval was one month. For the 16 patients who exhibits PUBS, bladder irrigation with normal saline and immediate change of urine bag and catheter were performed. And urine culture was done. Variables were statistically analyzed by chi square test or Mann-Whitney's U-test. P values less than 0.05 were considered statistically significant. Results: The PUBS patients mean age was 80, and bed ridden female. Most common diagnosis was dementia. Mean duration of the catheterization was 22 months. The PUBS patients were more constipated than non-PUBS control group and used more bisacodyl suppository. Antibiotics usage within one month before this survey in PUBS group is more frequent than control group with borderline statistical significance. Conclusion: PUBS is frequently occurring problem in long-term care geriatric wards. Causative factors are tryptophan putrefaction (decreased intestinal absorption, motility), alkaline urine, oxygen (air, Foley catheterization). All factors are bacterial infection related. Our results were the same as previous results. Relationship with antibiotics usage, bisacodyl suppository and constipation, long term usage of the Foley catheter notified also. Female predomination is related with easy, frequent urinary infection, and more population in old age.

      • KCI등재
      • KCI등재

        다양한 측정 환경 및 반사 조건에 대한 시각안전 LIDAR 신호 분석

        한문현,최규동,서홍석,민봉기,Han, Mun Hyun,Choi, Gyu Dong,Seo, Hong Seok,Mheen, Bong Ki 한국광학회 2018 한국광학회지 Vol.29 No.5

        LIDAR는 정밀 측정이 가능한 특성을 기반으로 정확한 정보 획득과 고해상도 3차원 영상 구현에 유리하기 때문에 사용자의 개입 없이 정확한 정보 획득과 판단이 요구되는 자율 주행 시스템에 필수적으로 적용되고 있다. 최근 LIDAR를 접목한 자율 주행 시스템이 인간의 생활권 안에서 활용되면서 시각안전 문제에 대한 해결과 함께 다양한 환경에서 정확한 장애물 인식을 통한 신뢰성 있는 판단이 요구되고 있다. 본 논문에서는 1550 nm 시각안전 광원을 활용한 Single-Shot LIDAR system (SSLs)을 구성하고 다양한 측정 환경, 반사 물질, 물질의 각도에 대한 LIDAR 신호 분석 방법과 결과를 보고한다. 실내, 주간, 야간의 환경에서 25 m 거리에 위치한 5% 알루미늄 반사판과 건물 벽을 활용하여 각 측정 환경에서 반사율이 다른 물질에 대한 신호를 분석하고, 다양한 각도를 갖는 실제 장애물을 고려하여 반사 물질의 각도 변화에 대한 신호 분석도 진행하였다. 이러한 신호 분석은 수신 정보의 신뢰도 판별을 위한 SNR과 거리 정보 정확성의 지표인 타이밍 지터를 활용하여 측정 환경 및 반사 조건과 LIDAR 신호 간의 상관관계 확인이 가능한 장점이 있다. Since LIDAR is advantageous for accurate information acquisition and realization of a high-resolution 3D image based on characteristics that can be precisely measured, it is essential to autonomous navigation systems that require acquisition and judgment of accurate peripheral information without user intervention. Recently, as an autonomous navigation system applying LIDAR has been utilized in human living space, it is necessary to solve the eye-safety problem, and to make reliable judgment through accurate obstacle recognition in various environments. In this paper, we construct a single-shot LIDAR system (SSLs) using a 1550-nm eye-safe light source, and report the analysis method and results of LIDAR signals for various measurement environments, reflective materials, and material angles. We analyze the signals of materials with different reflectance in each measurement environment by using a 5% Al reflector and a building wall located at a distance of 25 m, under indoor, daytime, and nighttime conditions. In addition, signal analysis of the angle change of the material is carried out, considering actual obstacles at various angles. This signal analysis has the merit of possibly confirming the correlation between measurement environment, reflection conditions, and LIDAR signal, by using the SNR to determine the reliability of the received information, and the timing jitter, which is an index of the accuracy of the distance information.

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