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Changes of Ubiquitin C-terminal Hydrolase L1 Following Ischemic Injury in Mouse Kidney
심세환,김석호,유명조,유일정,김종훈,임채웅,권중기,체가로바이리나,Keiji Wada,Sohail Ejaz,김범석 한국조직공학과 재생의학회 2009 조직공학과 재생의학 Vol.6 No.13
The kidney has shown the capacity to regenerate and repair after ischemic injury. However, the adult renal stem/progenitor cells are still not identified or characterized. It has been recently suggested that the renal papilla is a niche for adult renal stem cells. Here, we describe the characterization of ubiquitin C-terminal hydrolase L1 (UCH-L1) positive cells in the intact mouse kidney and their dynamics after ischemic injury. Previously, UCHL1 expression was identified in normal/pathologic kidney of human and rats, and suggesting that UCH-L1 functions in the regulation of the cell cycle and proliferation and in nephrogenesis. In this study, UCH-L1 was selectively expressed in the renal papilla, which was exclusively showed numerous BrdU-positive cells in the intact mouse kidney. In addition, UCH-L1/BrdU-positive cells were increased in the medulla and cortex after renal ischemic injury and both positive cells were colocalized. These results suggest that a function of UCH-L1 may be in repairing cells during mouse renal regeneration after ischemic injury.
사육사슴 및 야생고라니의 소 바이러스성 전염병에 대한 혈청학적 연구
조영숙 ( Young Suk Jo ),추금숙 ( Keum Suk Chu ),이정원 ( Jeong Woo Lee ),카머게리 ( Gerry A Camer ),체가로바이리나 ( Irina Chekarova ),설민숙 ( Min Suk Seol ),박현종 ( Hyun Jong Park ),김범석 ( Bum Seok Kim ),임채웅 ( Chae Woong Lim 한국가축위생학회 2009 韓國家畜衛生學會誌 Vol.32 No.2
Farmed deer could be susceptible carrier to bovine viral infectious disease. But unfortunately, there has not been an overall study over this subject in Korea so far. Therefore, a study was conducted to see serum antibodies to bovine leukosis, food and mouth disease, bovine viral diarrhea and infectious bovine rhinotracheitis in deer using the sera of farmed deer. As a result, two deer in a farms showed positive in bovine leukosis antibodies, using ELISA. For wild water deer, no antibodies were found for those diseases. As a result, it can be assumed that deer were relatively low rate of exposure to highly contagious disease such as viral bovine infectious disease in Korea. As this study was conducted over limited in number of subject and regions, continued study should be carried out in order to prevent and control the interspecies transmission in the future.