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Changes of Ubiquitin C-terminal Hydrolase L1 Following Ischemic Injury in Mouse Kidney
심세환,김석호,유명조,유일정,김종훈,임채웅,권중기,체가로바이리나,Keiji Wada,Sohail Ejaz,김범석 한국조직공학과 재생의학회 2009 조직공학과 재생의학 Vol.6 No.13
The kidney has shown the capacity to regenerate and repair after ischemic injury. However, the adult renal stem/progenitor cells are still not identified or characterized. It has been recently suggested that the renal papilla is a niche for adult renal stem cells. Here, we describe the characterization of ubiquitin C-terminal hydrolase L1 (UCH-L1) positive cells in the intact mouse kidney and their dynamics after ischemic injury. Previously, UCHL1 expression was identified in normal/pathologic kidney of human and rats, and suggesting that UCH-L1 functions in the regulation of the cell cycle and proliferation and in nephrogenesis. In this study, UCH-L1 was selectively expressed in the renal papilla, which was exclusively showed numerous BrdU-positive cells in the intact mouse kidney. In addition, UCH-L1/BrdU-positive cells were increased in the medulla and cortex after renal ischemic injury and both positive cells were colocalized. These results suggest that a function of UCH-L1 may be in repairing cells during mouse renal regeneration after ischemic injury.