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두개 기저부 척삭종의 세포유전학 및 분자생물학의 최신 지견
안정용(Jung Yong Ahn),심유식(Yu Shik Shim),조준형(Jun Hyung Cho),장종희(Jong Hee Chang),이규성(Kyu Sung Lee) 대한두개저학회 2008 대한두개저학회지 Vol.3 No.1
Chordomas are rare, low-to-intermediate grade malignant tumors arising from notochordal remnants in the midline skeletal axis. They account for <1% of central nervous system tumors and <5% of all primary malignant bone tumors. It is characterized by slow growth, local recurrence, and low metastasis rates. An increasing variety of techniques is now available to detect genetic alterations in chordomas, herein, we review the current knowledge of the genetic alterations in the skull base chordomas. The distribution of copy number changes is composed by two approaches; the low-resolution banding karyotyping and high-resolution whole genome CGH approach. The mapping of candidate genes in chordoma genesis awaits the application of high resolution targeted approaches. Chromosome 1p36.13 and 7q33 represent a candidate region for a chordoma gene. In gene expression study, many genes, such as HER2/neu, epidermal growth factor receptor, c-Met, platelet-derived growth factor receptor A and B, KIT receptors, E-cadherin, neural cell adhesion molecule, progesterone receptor B, estrogen receptor alpha, transforming growth factor alpha and basic fibroblast growth factor, fibronectin, and Cathepsin K, are differentially expressed and act a potential therapeutic target.
수 차례 재발한 스파르가눔증으로 치료를 받았던 환자에서 발생한 폐 스파르가눔증
오윤정 ( Yun Jung Oh ),김미진 ( Mi Jin Kim ),조준형 ( Jun Hyung Cho ),차치운 ( Chi Woon Cha ),김도훈 ( Do Hoon Kim ),오미정 ( Mi Jung Oh ),진재용 ( Jae Yong Chin ),최성실 ( Sung Sil Choi ),권계원 ( Kye Won Kwon ) 대한결핵 및 호흡기학회 2009 Tuberculosis and Respiratory Diseases Vol.67 No.3
Sparganosis is a zoonosis caused by the migrating larvae of cestode genus Spirometra. We report a rare form of sparganosis that invades the lung. A 44-year-old man presented with newly appeared pulmonary nodules that were found accidentally on regular medical checkup, and on sequential chest CT, which we checked at an interval of every 2 months, revealed that the pulmonary lesion had migrated. The patient had a medical history of having undergone surgical excisions for sparganosis in muscles and in subcutaneous tissues of the lower abdomen, perianus, thigh, right axilla, and scapula area, several times over 7 years. A right middle lobectomy was performed and the lesion was diagnosed as sparganosis based on the characteristic histological findings.
제지용 도공안료의 표면개질에 의한 도공지 물성과 인쇄적성에 관한 연구 (1)
민동진 ( Dong Jin Min ),조준형 ( Jung Hyung Cho ),이용규 ( Yong Kyu Lee ),김용식 ( Yong Sik Kim ) 한국공업화학회 2003 공업화학 Vol.14 No.2
제지산업에 경쟁력을 부여찰 수 있는 방법의 일환으로 제지용 무기안료외 표면을 개질처리하였다. 재지용 무기안료인 clay, talc, CaCO_3, TiO_2의 입도를 측정한 뒤, 선택된 모입자(clay,talc, CaCO_3)와 자입자(TiO_2)를 계산식에 의한 배합비로 혼합하였, 분체의 대전현상을 이용하여 모입자 주위에 자입자를 부착시킨 다음 고속기류 중 충격력으로 개질처러하였다. 표면개질시 자입자가 모입자에 흡착될 때의 에너지를 측정하여 입도 변화에 따른 표면개질 효율성을 측정하였다. 표면개질안료와 혼합안료의 백색도, 산란도 등을 측정하여 표면개질처리시 안료외 광학적 성질변화를 확인하였다. 그리고 표면개질된 안료를 액상에 투입하고, 입자전하측정기와 재타전위측정기를 이용하여 정전기적 성질변화를 측정하였다. 본 연구의 결과로부터, 표면개짙처리된 제지용 무기안료의 기본적인 분체물성이 개선되었음을 알 수 있었다. The surface of inorganic pigments was modified as an alternative method to provide a competitive edge for the nation`s paper industries. The particle sizes of inorganic pigments for paper applications such as clay, talc, CaCO_3, and TiO_2 were measured. The selected core particles and fine particles were then mixed at a calculated ratio. When the sample was electrified the fine particles adhered to the larger ones due to the static electricity. These powders were then modified by the impact force resulting from a very high-speed air circulation. During the surface modifying of pigments, the energy change caused by the fine powder adhering to the core powder was measured and utilized in examining the efficiency of the surface modification due to the change in particle size. The change of optical properties of pigment during the surface modification was confirmed by measuring the brightness and scattering rate of surface modified pigments and mixed pigments. After putting these surface modified pigments in water, their static electricity properties were measured with a particle charge detector and a zeta potential tester. From these results, it was revealed that some of the basic powder properties of paper-making inorganic pigment were improved.
토끼에서 oxytetracycline의 정맥 및 근육 투여시의 약물동태학
김은정,윤효인,박승춘,오태광,조준형,Kim, Eun-jung,Yun, Hyo-in,Park, Seung-chun,Oh, Tae-kwang,Cho, Chun-hyung 대한수의학회 1994 大韓獸醫學會誌 Vol.34 No.2
The study was carried out to determine the pharmacokinetic parameters after intravenous(iv) and intramuscular(im) administration (10mg/kr) in healthy rabbits. The results obtained through the experiments were summarized as follows: 1. Bioassay (Bacillus cereus 11778) was evaluated very useful for the determination of oxytetracycline(OTC) in the rabbit serum and tissues, with the detection limit of $0.125{\mu}g/ml$. 2. The pharmacokinetic profiles of OTC (10mg/kg, iv) in rabbits were best described with a two compartment open model $(C=29.5e^{-4,3t}{\pm}3.6^{-0.2t})$, whereas that of OTC (10mg/kg, im) showed a one compartment curve fitting. 3. Following iv administration, a rapid distribution phase was predominant [$t_{\frac{1}{2}}({\alpha}):1.43{\pm}0.98hr$ (♂), $0.5{\pm}0.1hr$(♀)], and then more slow elimination phase ensued [$t_{\frac{1}{2}}({\beta}):4.52{\pm}0.76hr$(♂), $7.32{\pm}2.52hr$(♀)]. Other computer generated pharmacokinetic values were as follows:C1 [$67.76{\pm}18.59ml/kg/h$(♂), $76.03{\pm}22.98ml/kg/h$ (♀)] Vd [$257.74{\pm}180.47ml/kg$ (♂), $92.33{\pm}23.62$ (♀)] AUC [$25.6{\pm}4.44mgh/L$ (♂), $39.6{\pm}12.13mgh/l$ (♀)]. There were no statistical significance between both sexes for all the parameters at the confidence level of 95%. 4. After im administaration, the absorption from the injection sites was very rapid [ Ka:$0.18{\pm}0.03h^{-1}$ (♂), $0.24{\pm}0.02h^{-1}$ (♀)] followed by a monoexponential elimination fashion. The time to peak blood level (Tmax) were calculated $1.64{\pm}0.15hr$ and $1.34{\pm}0.24hr$, in the male and female, respectively. The peak levels (Cmax) at the corresponding time were $1.69{\pm}0.23{\mu}g/ml$ (♂) and $2.08{\pm}0.16{\mu}g/ml$ (♀), with no statistical differences (p>0.05).
HYSTAP 장치를 이용한 펄프슬러리 내 첨가제들의 응집특성 평가
최경화(Kyoung-Hwa Choi),박정은(Jung Eun Park),조준형(Jun Hyung Cho) 한국펄프·종이공학회 2018 펄프.종이技術 Vol.50 No.2
Effects of molecular weight and charge density of a C-PAM (cationic polyacrylamide) used as a retention aid on the flocculation of the pulp slurry have been investigated by measuring a hydrostatic pressure using the hydrostatic pressure tester (HYSTAP). It was found that a hydrostatic pressure of pulp slurry was increased with increasing C-PAM dosages. Flocculation property between PCC (precipitated calcium carbonate) and pulp fibers in pulp slurry was improved by C-PAM addition. Especially, the flocculation property of pulp slurry increased with when higher molecular weights and charge densities of C-PAM were added. While, the formation of handsheets was decreased with the improvement of flocculation property of pulp slurry samples by addition of C-PAM. These decreasing tendency was corresponding with the increasing changes of hydrostatic pressure of pulp slurry samples in respect of molecular weights and charge densities of CPAM. The tensile strength of handsheets was slightly decreased by addition of C-PAM while the burst strength was not changed. The changes in tensile strength of handsheet according to a molecular weight of C-PAM were agreed with those of a hydrostatic pressure. But, the changes in respect with the charge density of C-PAM wasn’t corresponding with the change of a hydrostatic pressure. In other words, tensile strength of handsheet was most decreased by addition of the C-PAM having a lowest charge density.