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초음파 장비를 활용한 시멘트 페이스트 단위수량 예측에 관한 실험적 연구
조양제 ( Cho Yang-je ),이한승 ( Lee Han-seung ) 한국건축시공학회 2020 한국건축시공학회 학술발표대회 논문집 Vol.20 No.1
Unit-water content is an element directly related to durability and unit-water content of concrete used at construction site has a great effect on the durability of construction structure. Many methods are being discussed for more convenient and accurate measurements of unit-water content. Therefore, an experimental study was conducted on the prediction of unit-water content using ultrasonic equipment. Depending on the amount of cement in cement paste, the speed of ultrasonic waves varies and the experiment will be carried out using the same reception sensitivity in the future.
딥러닝 모델 구조에 따른 모르타르의 단위수량 평가에 대한 비교 실험 연구
조양제 ( Cho¸ Yang-je ),유승환 ( Yu¸ Seung-hwan ),양현민 ( Yang¸ Hyun-min ),윤종완 ( Yoon¸ Jong-wan ),박태준 ( Park¸ Tae-joon ),이한승 ( Lee¸ Han-seung ) 한국건축시공학회 2021 한국건축시공학회 학술발표대회 논문집 Vol.21 No.2
The unit-water content of concrete is one of the important factors in determining the quality of concrete and is directly related to the durability of the construction structure, and the current method of measuring the unit-water content of concrete is applied by the Air Meta Act and the Electrostatic Capacity Act. However, there are complex and time-consuming problems with measurement methods. Therefore, high frequency moisture sensor was used for quick and high measurement, and unit-water content of mortar was evaluated through machine running and deep running based on measurement big data. The multi-input deep learning model is as accurate as 24.25% higher than the OLS linear regression model, which shows that deep learning can more effectively identify the nonlinear relationship between high-frequency moisture sensor data and unit quantity than linear regression.
고주파 수분 센서를 이용한 시멘트 모르타르의 단위수량 측정에 관한 기초적 연구
조양제 ( Cho Yang-je ),김민서 ( Kim Min-seo ),윤종완 ( Yoon Jong-wan ),박태준 ( Park Tae-joon ),이한승 ( Lee Han-seung ) 한국건축시공학회 2020 한국건축시공학회 학술발표대회 논문집 Vol.20 No.2
The unit-water content of concrete is one of the important factors in determining the quality of concrete and is directly related to the durability of the construction structure, and the current method of measuring the unit-water content of concrete is applied by the Air Meta Act and the Electrostatic Capacity Act. However, there are complex and time-consuming problems with measurement methods. Therefore, high frequency moisture sensor was used for quick and high measurement, and unit-water content of mortar was evaluated through machine running and deep running based on measurement big data.
고주파 수분 센서를 이용한 모르타르의 단위수량 평가에 관한 실험적 연구
조양제 ( Cho Yang-je ),유승환 ( Yu Seung-hwan ),양현민 ( Yang Hyun-min ),윤종완 ( Yoon Jong-wan ),박태준 ( Park Tae-joon ),이한승 ( Lee Han-seung ) 한국건축시공학회 2021 한국건축시공학회 학술발표대회 논문집 Vol.21 No.1
The unit-water content of concrete is one of the important factors in determining the quality of concrete and is directly related to the durability of the construction structure, and the current method of measuring the unit-water content of concrete is applied by the Air Meta Act and the Electrostatic Capacity Act. However, there are complex and time-consuming problems with measurement methods. Therefore, high frequency moisture sensor was used for quick and high measurement, and unit-water content of mortar was evaluated through machine running and deep running based on measurement big data.
CFC-101 ( 녹농균 백신 ) 의 능동 및 수동면역 효과
김영지(Young Gi Kim),김제학(Je Hak Kim),박완제(Wan Je Park),김유삼(Yu Sam Kim),함경수(Kyung Soo Hahm),조양제(Yang Je cho),박관하(Kwan Ha Park) 한국응용약물학회 1994 Biomolecules & Therapeutics(구 응용약물학회지) Vol.2 No.4
The treatment of pseudomonal infection is a perplexed problem because of its modest susceptibility to most of the major antibiotics. A novel Pseudomonas vaccine(CFC-101) was prepared from the outer membrane protein fractions of several Pseudomonas strains. In this study, we examined CFC-101`s effectiveness in both active and passive immunization models. CFC-101 in mice at 0.2 mg/kg, i.p., given three times at two-day intervals, completely prevented the death caused by Pseudomonas aeruginosa. Antibody titer, in accordance with the protective effect in this active immunization, was elevated to its peak level following three consecutive administrations of CFC-101. Thereafter, antibody titer stayed at a constantly high level. Each outer membrane protein fraction from the four CFC-101 producers, exhibited good cross-protective effects in mouse infection models against different Fisher types of P. aeruginosa. In the passive immunization model, 21∼336 ㎍/㎏ of anti-rabbit IgG to CFC-101, when mice being infected with a challenge strain, prevented the Pseudomonas-induced death up to 60%. Therefore, the preventive effect of CFC-101 was verified in both the active and passive immunization models.
김윤희(Yoon Hee Kim),이준수(Joon Soo Lee),김흥동(Heung Dong Kim),조양제(Yang Je Cho),강진호(Jin Ho Kang),이종찬(Jong Chan Lee),강훈철(Hoon-Chul Kang) 대한소아신경학회 2010 대한소아신경학회지 Vol.18 No.2
Purpose : Sleep disorders cause serious complications to growth and development in children given that sleep plays an important role in maintaining physical and psychological health. In this study, we investigated the clinical characteristics of sleep disorders in childhood and adolescence, their polysomnographs (PSG), as well as other related diseases. Methods : Forty-two patients who took PSG in Severance Children's Hospital from September 2006 to April 2010 were involved in this study. Their medical records were retrospectively reviewed. Results : Among 42 patients, there were 29 boys and 13 girls; their mean age was 9 years 10 months. Twenty-three (55%) patients reported headache as their chief complaint. Symptoms associated with headache were insomnia, snoring and mouth breathing, daytime sleepiness, abnormal behavior during sleep, and hyperactivity. Among the 23 patients with headaches, nine (39%) had abnormal PSG. Among 21 patients with snoring and mouth breathing, only five (24%) were diagnosed as obstructive sleep apnea and others had primary snoring. In the analysis of sleep disorders according to age, obstructive sleep apnea was evenly distributed across all ages. Conclusion : In this study, various clinical symptoms related to childhood and adolescence sleep disorder with headache being the most common symptom. Although sleep disorders are harmful to children and adolescence, they are frequently overlooked. Therefore, careful attention related to the diagnosis and treatment of sleep disorders is required.
녹동균 세포외막 단백질 백신 CFC-1-101의 안정성 및 면역원성 검토 : 임상 제 Ⅰ/Ⅱa상 시험
장인진,김익상,유경상,임동석,김형기,신상구,장우현,박완제,이나경,정상보,안동호,조양제,안보영,이윤하,김영지,남성우,김현수 대한감염학회 1998 감염 Vol.30 No.3
목적 : 제일제당에서는 녹농균의 세포외막 단밸질을 유효성분으로 하는 백신인 CFC-101을 개발하였으며, 동물시험에서 이 백신의 안전성과 유효성을 입증하였다. 본 연구에서는 이 녹농균 백신의 인체에 대한 안전성과 면역원성을 평가하는 동시에 인체 접종시의 최적 투여 용량을 결정하기 위하여 제 I/Ⅱa상 임상시험을 수행하였다. 방법 : 건강한 성인 남자를 피험자로 선별하여 각 용량군에 백신투여자 6명, 위약투여자 2명을 배정하였다. 백신 투여군은 0.25mg, 0.5mg 또는 1.0mg 용량의 녹농균 백신을 7일 간격으로 3회에 걸쳐 근육주사 하였으며, 위약 투여군에게는 세포외막 단백질을 제외한 동일한 성분을 투여하였다. 백신접종 후 국소적 또는 전신적인 반응의 발생여부를 관찰하고, 혈액시료를 체취하여 백신의 역가와 유효성을 검정하였다. 결과 : 녹농균 백신 CFC-101은 모든 접종자에서 양호한 내약성을 보였다. 또한 0.5mg 과 1.0mg 백신 투여군에서는 100%의 항체양전율을 나타내었다. 생성된 항체는 녹농균 세포외막단백질에 특이성을 보였고, 녹농균 감염에 대해 방어효능이 있었다. 결론 : 이와같은 결과로부터 이 녹농균 백신은 인체에 안전하게 투여할 수 있으며, 높은 항체 생성능으로 감염방어 효능을 보이고 0.5mg과 1.0mg이 최적용량인 것으로 판단되었다. Background : We developed a Pseudomonas aeruginosa outer membrane protein(OMP) vaccine CFC-101, and the prophylactic efficacy of which has been demonstrated in animal models. In order to evaluate the safety and immunogenicity of the P. aeruginosa vaccine, we carried out a phase I/Ⅱa clinical trial in healthy male volunteers. Methods : Groups of eight volunteers, including two placebo subjects, were vaccinated intramuscularly with three doses of 0.25, 0.5 or 1.0 mg of the vaccine at one week intervals. Sings of systemic and local reactions observed after vaccination were recorded for each vaccinee for 5 days. Physical examinations were performed on days 0, 1, 7, 8, 14, 15, 21, and 42, and clinical laboratory tests were done on days 0, 3, and 21. Blood samples for assay of serum antibody levels were obtained up to 42 days after the first vaccination. Results : The vaccine was generally well tolerated by all vaccinees, showing no significant side effects. In the three dosage groups, all vaccinees, except one receiving the 0.25 mg dose, showed significant elevation in serum IgG antibody titers against the vaccine proteins, indicating 100% seroconversion in 0.5 and 1.0 mg groups. The human antibodies induced by the vaccine were specific for P. aeruginosa OMPs, as confirmed by western blot analysis and immunoprecipitation assays. The capacity of the human antisera to enhance opsonophagocytic killing activity by polymorphonuclear leukocytes and to confer protection against P. aeruginosa infections indicates that the antibodies elicited by the vaccine have protective efficacy. Conclusion : We conclude that the P. aeruginosa OMP vaccine is safe and effective for human use and its optimal dose to be 0.5 or 1.0 mg.