Chronic Obstructive Pulmonary Disease in a Dressage Horse

정효훈,안계명,김아람,노하정,오태호 한국임상수의학회 2010 한국임상수의학회지 Vol.27 No.2

A 14-year-old gelded dressage horse weighing 500 kg was presented to the Equine Medical Center of the Seoul Racecourse of Korea Racing Authority (KRA) due to coughing and mucopurulent nasal discharge. The horse was initiated with empirical antibiotic in the first place. However, the clinical signs did not improve but were rather exacerbated even after 3 weeks of therapy. Extensive diagnostic procedures including transtracheal wash (TTW) fluid cytology were undertaken. The localized wheezes and crackles were auscultated and an increase in the amount of mucopurulent exudate in trachea was observed at endoscopy. Infiltration of neutrophils was observed in the TTW fluid cytology implying chronic obstructive pulmonary disease (COPD). Therefore, the systemic glucocorticoid therapy was to be given for 3 weeks with improved ventilation provided at the same time. The respiratory symptoms started to improve in 7 days of therapy and were fully resolved by when the therapy was terminated. The horse is clinically normal now and being monitored for development of any signs of chronic obstructive pulmonary disease.

Uroperitoneum Secondary to the Rupture of the Urinary Bladder in a Thoroughbred Foal

정효훈,박경원,이은비,강태영,서종필 한국임상수의학회 2021 한국임상수의학회지 Vol.38 No.6

A 13-day-old Thoroughbred female foal weighing 59 kg was referred to the Jeju National University Equine Hospital with clinical signs including depression, labored breathing, tachycardia, anorexia, and marked distended abdomen. Uroperitoneum secondary to a rupture of the urinary bladder was diagnosed based on the history, clinical signs, and ultrasound imaging. An emergency laparotomy for cystorrhaphy under inhalation anesthesia was performed, and the patient recovered uneventfully. A course of extensive supportive therapy with systemic antibiotics after surgery was carried out. The foal fully recovered and was discharged after 14 days of hospitalization. The follow-up after seven months revealed the patient to be clinically healthy. This report describes a case of uroperitoneum secondary to the rupture of the urinary bladder in a Thoroughbred foal, along with the clinical outcomes of surgical repair and intensive treatment in detail.

Recurrent Superficial Pyoderma Caused by Mixed Infection of Proteus mirabilis and Staphylococcus pseudointermedius in a Yorkshire Terrier Dog

정효훈,오태호 한국임상수의학회 2011 한국임상수의학회지 Vol.28 No.5

An 8-year-old spayed Yorkshire Terrier Dog was presented to the Veterinary Teaching Hospital of Kyungpook National University because of the recurrent superficial pyoderma. At the presentation, pustules and papules were present throughout the body. Numerous rods with a few cocci were observed on impression smears and they were confirmed to be Proteus mirabilis and Staphylococcus pseudointermedius consecutively. The patient was treated with systemic enrofloxacin and amoxicillin-clavulanic acid based on the results of antimicrobial sensitivity tests with once a week basis 4% chlorhexidine shampoo. An excellent clinical response was achieved in 2 weeks of therapy and the lesions were fully resolved in 6 weeks. The possibility of P. mirabilis infection should not be overlooked by clinicians in dogs with recurrent superficial pyoderma although it’s been considered to be rare.

황백, 연교 및 감초 추출물을 이용한 국소제제의 Staphylococcus intermedius에 대한 항균효과

정효훈,오태호 한국임상수의학회 2005 한국임상수의학회지 Vol.22 No.4

This study was performed to examine the antibacterial efficacy of topical agent extracted from Phellodendri cortex, Forsythia fructus and Glycyrrhizae radixas an alternative dermatological agent. Also, the most efficacious concentration of this agent and the skin-contact time inhibiting the vegetation of bacterial cells in various dilutions were determined. Five strains of Staphylococcus intermedius were exposed to various dilutions of this agent. The efficacy was assessed after exposure for time periods varying between 0 and 30 min. The antibacterial efficacy was shown to be the strongest at dilution of 1 : 2. The number of viable organisms decreased significantly after 8 minutes of exposure time and was the smallest after 30 minutes of exposure time. This alternative dermatological agent is considered to be effective against Staphylococcus intermedius and has a potential to be a new topical agents for the treatment of pyoderma in dogs.

양액내 NO3--N과 NH4+-N의 비율이 체리 세이지와 파인애플 세이지의 생육 및 생리반응에 미치는 영향

정효훈,이영현 한국인간·식물·환경학회 2007 인간식물환경학회지 Vol.10 No.4

체리 세이지(Salvia coccinea L.)와 파인애플 세이지(Salvia officinalis L.)을 수경재배 할 때, 양액내 NO3--N : NH4+-N의 비율이 두 품종 허브의 생육에 미치는 영향과 성분에 미치는 영향을 알아보고자 질산태질소와 암모늄태 질소의 비를 100:0, 75:25, 50:50, 25:75, 0:100의 다섯 개의 처리구를 나누어 실험하였으며 아래와 같은 결론을 얻었다. 체리 세이지와 파인애플 세이지의 생육에서는 NO3--N : NH4+-N의 비가 50:50과 75:25인 처리구의 생장이 21.9cm, 23.4cm로 NH4+-N 단용 처리구보다 생장율이 높았다. NH4+-N 의 함유량은 체리세이지의 shoot의 25:75 혼용구에서 38mg/g DW로 가장 낮은 함유량을 보였으며, 75:25의 혼용구에서 44mg/g DW를 보였고, 파인애플 세이지는 45mg/g DW의 가장 높은 함유량과 38mg/g DW의 가장 낮은 함유량을 보였으며 50:50의 비에서 40mg/g DW의 함유량을 보였다. NRA의 함유량은 시간이 지나면서 shoot에서 많은 활성을 보였고 체리세이지는 NO3--N : NH4+-N비가 50:50인 혼용 처리구에서 0.81nmole/g FW ․ h-1의 함유량을 보였고 파인애플 세이지는 50:50 혼용구에서 최대 0.86nmole/g FW ․ h-1의 함량을 나타내었다. GSA(glutamine synthtase activity)의 활성에서 12주후, 체리 세이지는 질산태 질소 단용구에서 9.2umole/g FW ․ h-1의 함량을 파인애플 세이지는 11umole/g FW ․ h-1의 높은 함량을 보였다. 이상의 결과로 NO3-의 단용구 또는 NH4+의 단용구보다는 NO3--N : NH4+-N의 혼용구에서 생육의 증가를 보였고, NRA의 함량과 생장 또한 단용구보다는 혼용구에서 높게 나타났음을 알 수 있었다. 특히 NO3--N : NH4+-N의 처리비가 75:25 에서의 혼용 처리구에서 다른 혼용구보다 생육의 높은 증가를 보였다. 따라서 75:25의 혼용비가 두 종의 세이지 생육에 적합한 비라고 생각된다. This study was conducted to investigate the effect of five different NO3--N : NH4+-N ratio (100:0, 75:25, 50:50, 25:75, 0:100) in nutrient solution on the growth responses of cherry sage(Salvia coccinea L.) and pineapple sage(Salvia officinalis L.). Cherry sage and pineapple sage were grown under the condition of those treatments for twelve weeks. Cherry sage was showed that shoot length remarkably increased was grown the greatest when NO3--N : NH4+-N treatment was 75:25, but pineapple sage was 50:50. However, when NO3--N : NH4+-N ratio was 100:0 or 0:100, those shoot length was showed the poorest. NRA(nitrate reductase activity) was increased in the condition of those treatments for twelve weeks. In the shoot case, NRA of cherry sage was the highest when NO3--N : NH4+-N treatment was 50:50, and pineapple sage was 75:25. At 25:75 or 50:50 ratio, those of soluble protein, total nitrogen, free amino acid and nitrate contents were increased, but was not showed significant. At 0:100 ratio, those contents was showed more lower. After 12 weeks, GSA(glutamine synthetase activity) was increased in the shoot of both cherry sage and pineapple sage, and NO3--N : NH4+-N treatment was 75:25 ratio that was appearanced the highest in those GSA content. So, the growth responses of cherry sage and pineapple sage were suitable at NO3--N : NH4+-N ratio(75: 25).

양액내 NO₃_N : NH₄_N의 비율에 따른 체리 세이지와 파인애플 세이지의 생육 및 생리반응

정효훈(Hyo-Hun Jung),이영현(Young-Hyun Lee) 한국생물환경조절학회 2007 한국생물환경조절학회 학술발표논문집 Vol.16 No.2

실내조경 소재개발을 위한 자생 상록양치류의 대량번식 : 2. 포자배양에 의한 배양온도, 조명시간 및 배지가 전엽체 발달에 미치는 영향

이영현,정효훈 순천향대학교 기초과학연구소 2006 순천향자연과학연구 논문집 Vol.12 No.2

This study was carried out to establish the mass propagation system of korea green native ferns in vitro for developing materials of interior landscape architecture. This study was also performed to investigate the effect of cultural temperature, light time and medium on the development of prothallus in korea green native ferns. The clone formation of cultural temperature, up to 30℃ , was enhanced the formation of prothallus in Crytomium fatcatum, Asptenium scotopendrium, and PoIystichum tepidocauton. The 16 hours of light time for prothallus formation were favorable in korea native ferns when compare to the dark condition, In the case of medium, prothllaus clone formation were more effective on the culture with MS than the 1/2 MS and agar medium in each species.

Effects of Loratadine, Cetirizine, and Terfenadine on Histamine-Induced Wheal and Erythema Responses in Normail Canine Skin

정아영,정효훈,허우필,엄기동,장광호,오태호 한국임상수의학회 2002 한국임상수의학회지 Vol.19 No.2

This crossover study was performed in order to compare the effects of cetirizine, loratadine, and terfenadine in canine skin. Five healthy dogs were used. Cetirizine 0.5mg/kg, loratadine 5mg and terfenadine 5mg/kg were administered orally 4 hours before the experiment. Erythema indices and wheal size were assessed by Mexameter (MX 18, CK, Germany) and skin reaction guide, respectively. Cetirizine-induced erythema inhibition was generally higher than other drugs and was significantly different from placebo. Cetirizine was superior to placebo at 3, 4, 5, 6, 7, and 8 minutes (p<0.01). Cetirizine also was superior to placebo at 9 minutes (p<0.05). Loratadine and terfenadine erythema inhibition were better than after placebo treatment from 4 to 9 minutes, but erythema index of terfenadine at 7 minutes was not observed probability of 95% and 99%. At 10 minutes, intradermal injection of the histamine caused a mean wheal dimension for placebo, cetirizine, loratadine, and terfenadine, which were 13.25±0.75mm, 7.5±1.02mm (53% reduction, P<0.007), 6.2±0.58mm (43% reduction, p<0.01), and 8.4±0.67mm (37% reduction, p<0.05), respectively, comparing with placebo. Loratadine and cetirizine were good antihistamines for clinical therapy for atopic dermatitis in dog.

개에서 Malassezia 피부염에 대한 itraconazole 치료 18례

정아영,허우필,정효훈,엄기동,이근우,오태호 한국임상수의학회 2005 한국임상수의학회지 Vol.22 No.2

Itraconazole was found to be an effective antifungal for the treatment of canine Malassezia dermatitis (MD). MD was diagnosed in 18 dogs, which were treated with itraconazole administered orally at 5mg/kg of body weight, q12hrs, for 21 to 30 days. High prevalence breeds of MD were Maltese (22%), Cocker Spaniel (17%), Pekingese (11%), and Vizsla (11%). The dermatological signs of Malassezia dermatitis were crust (31%), alopecia (25%), hyperpigmentation (25%), scales (19%), erythema (13%), lichenification (11%), pustule (11%), ear swelling (11%), papules (5%), and offensive odor (5%). Commonly affected areas were ear canal (41%), axillae (18%), groin (15%), perianal (12%), ventral aspect of the neck (9%), interdigital spaces (1%), and muzzle (1%). Sixty seven percent of dogs with MD had cocci. Clinical responses of itraconazole were seen good, moderate, no responses of itraconazole, in 89%, 0%, and 11%, respectively, according to the owner's satisfaction to follow up call. Recurrence was detected on five good responsive dogs and adverse effects of the treatment were detected in only one dog. On the basis of this clinical study, itraconazole is a good choice in the treatment of canine Malassezia dermatitis. Efficacy, frequency of administration and veterinary approval are the major advantages.

경주마에서 와이어와 폴리메틸메타크릴레이트 합성충진제를 사용한 제측열제의 치료 1례

박경원,안승주,이은비,천용우,정효훈,강태영,서종필 한국임상수의학회 2020 한국임상수의학회지 Vol.37 No.5

A 4-year-old Thoroughbred stallion was referred to J&C Equine Hospital with a quarter crack of the right front foot. On visual inspection, there was a medial quarter crack with laminar necrosis. The first step to treat this problem was to remove the necrotized tissue around the crack using Dremel tools, disinfecting crack, administering antibiotics through regional limb perfusion and systemically administering antibiotics and anti-inflammatory drugs consistently. After one month’s anti-inflammatory management, the quarter crack was treated successfully using two series of wiring with one week’s term and polymethylmethacrylate composites (Equilox ). After treatment, this racehorse successfully resumed training and racing in Korea Racing Authority Seoul Race Course, and won three times, finishing second and third place once, out of thirteen starts.