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임기정(Gi Jung Im),신영기(Young Gi Cinn),장지원(Ji Won Chang),최준(Joon Choi),채성원(Sung Won Chae),정학현(Hak Hyun Jung) 고려인삼학회 2009 Journal of Ginseng Research Vol.33 No.2
Sudden idiopathic sensorineural hearing loss is a disease that develops within several hours to several days. Its etiology has not yet been verified, but the disturbance of the circulation of blood in the inner ear, inner-ear hydrops, and viral infection are considered possible causes of the disease. This study was conducted to evaluate the effect of Panax ginseng extract, which is known to have a vasodilatory effect, on sudden sensorineural hearing loss. Sixty-nine patients suffering from sudden sensorineural hearing loss were admitted to Korea University Anam Hospital from March to December 2008. They were divided into the experimental (30 ears) and control (39 ears) groups. Ginseng extract (2700㎎/day, 4 weeks) was added to the therapeutic regimen in the experimental group. The effect of ginseng extract therapy was analyzed according to the factors relating to the prognosis. A considerable hearing improvement was documented in both groups (32.2 ㏈ in the experimental group and 25.8 ㏈ in the control group). However, there was little beneficial effect of ginseng extract on additional hearing improvement compared with control. The total recovery rate of the experimental group (80.0%) was better than that of the control group (58.9%), and the experimental group’s high-tone hearing gain at 3 ㎑ (29.7 ㏈) was better than that of the control group (21.7 ㏈). The results of the study suggest that the effects of ginseng therapy tend to be superior to those of the conventional therapy, but the difference between the two is not statistically significant. The hearing gains tend to be in the higher frequencies and may be due to the promotion of cellular differentiation from the supporting cells.
기니픽의 正圓窓膜에서 高分子量 物質의 透過性에 關한 電子顯微鏡的 硏究
鄭學鉉,柳洪均 고려대학교 의과대학 1991 고려대 의대 잡지 Vol.28 No.1
Studies on the permeability of the round window membrane. which is the barrier between the middle ear and inner ear, are important because ototoxic substances that occur in otitis media with effusion have the potential to cross the round window membrane and to cause inner ear damage. The permeability of electron dense tracers, such as cationized ferritin, ferritin and iron dextran, was studied in the normal and endotoxin (lipopolysaccharides from E.coli) induced pathologic round window membrane of guinea pig under transmission electron microscopy to investigate changes of the permeability of macromolecules in otitis media. In the normal round window membrane, cationized ferritin and irom dextran were penetrated into the epithelial cell by pinocytosis and were founded in the middle and inner layer, but ferritin was not penetrated into the epithelial cell. The pathologic round window membrane, 3 days following the application of endotoxin, showed the morphologic alteration, such as vacuolation of epithelial cell, interstitial edema and polymorphonuclear leukocytes infiltration in the middle layer, but there were no disruption of intercellular junction and epithelial loss. In the pathologic round window membrane, the permeability of cationized ferritin and iron dextran was not increased and ferritin was not penetrated into the epithelial cell. In otits media, the defense mechanism of the round window membrane must be taken into consideration. This study suggests that electronic charge of substances as well as molecular weights are important in the permeability of round window membrane and early stage of endotoxin induced otitis media does not act as promotive factor of pinocytosis in the round window membrane.