헤모글로빈 부가체를 이용한 염료제조 근로자의 노출평가

노재훈,장규엽,이경종,김치년,윤영식 한국산업위생학회 2000 한국산업보건학회지 Vol.10 No.2

This study was performed to investigate monoacetylbenzidine(MABZ) and benzidine(BZ) hemoglobin adducts among workers who worked at benzidine based dye manufacturing company, and exposed by benzidine and benzidine based dye. The hemoglobin adducts were compared with work environment assessment result far evaluating the usefulness of biological monitoring The mean BZ hemoglobin adducts among the first synthesis worker's hemoglobin adducts were 40.69 ㎍BZ/g Hb and those of dry and packing workers were 22.14 ㎍BZ/g Hb. The mean of MABZ hemoglobin adducts among 1st synthesis workers were 255.84 ㎍MABZ/g Hb, dispersion worker's hemoglobin adducts were 76.17 ㎍MABZ/g Hb and synthesis worker's hemoglobin adducts were 28.66㎍MABZ/g Hb. Work environment assessment results during past 3 years were 0.0065 ㎎/㎥ and 0.5659 ㎎/㎥ of benzidine based dye concentration in ambient air of drying and packing only. Dye producing process was categorized by the possibility of exposure to benzidne and benzidine based dye. BZ and MABZ hemoglobin adducts were 19.55 ㎍BZ/g Hb, 119.80 ㎍MABZ/g Hb among workers who exposed by benzidine dihydrochloride and 16.32 ㎍BZ/g Hb, 316.56 ㎍MABZ/g Hb among workers who exposed by benzidine based dye. BZ hemoglobin adducts were not detected among control grope and MABZ hemoglobin adducts were 5.33 ㎍MABZ/g Hb. The differences between control and other exposed group was statistically significant. But there was no statistically significant differences between benzidine dihydrochloride exposed process and benzidine based dye exposed group. BZ and MABZ hemoglobin adducts were 2.23 ㎍BZ/g Hb, 76.17 ㎍MABZ/g Hb and 3.46 ㎍BZ/g Hb, 21.33 ㎍MABZ/g Hb. So hemoglobin adducts of MABZ were 5∼0 time higher than those of BZ(P$lt;0.003). Above results indicate that work environment assessment didn't detected benzidine and benzidine based dye in ambient air but biological monitoring detected those of hemoglobin adducts. Two group's hemoglobin adducts exposed benzidine dihydrochloride and benzidine based dye were high level but wasn't statistically significant and those were not detected in control group.

다중이용시설 내부에 분포하는 부유 진균의 입경별 농도 특성

박재범,김기연,장규엽,김치년,이경종,Park, Jae-Beom,Kim, Ki-Youn,Jang, Gyu-Yeob,Kim, Chin-Yon,Lee, Kyung-Jong 한국환경보건학회 2006 한국환경보건학회지 Vol.32 No.1

The aim of this study is to examine size-based concentration and genera of airborne fungi distributed in public facilities such as hospital, kindergarten, day-care center and postpartum nurse center and to provide fundamental data in order to prevent respiratory diseases caused by exposure to airborne fungi. Culturable total and respirable concentrations of airborne fungi averaged to $382\;cfu/m^3\;and\;292\;cfu/m^3$ in hospital, $536\;cfu/m^3\;and\;347\;cfu/m^3$ in kindergarten, $334\;cfu/m^3\;and\;266\;cfu/m^3$ in day-care center, and $371\;cfu/m^3\;and\;289\;cfu/m^3$ in postpartum nurse center, respectively. The ratio of respirable to total concentration of airborne fungi in the investigated public facilities was ranged from $55\%\;to\;70\%$ but there was no significant difference among them (p>0.05). The mean I/O ratio of culturable total and respirable concentrations were 0.56 and 0.64 in hospital, 0.72 and 0.91 in kindergarten, 0.33 and 0.45 in day-care center, and 0.63 and 0.73 in postpartum nurse center, respectively. Indoor concentration of airborne fungi did not correlated significantly with indoor temperature and relative humidity (p>0.05) but had a significant positive correlation with $CO_2$ concentration (p<0.01) and surrounding condition (p<0.05). Penicillium spp., Cladosporium spp., and Aspergillus spp. were estimated to over $95\%$ of total airborne fungi identified in the investigated public facilities.

배지 종류 및 저장 조건에 따른 impactor의 부유세균 시료 채취 효율 평가

이경종,김기연,장규엽,박재범,김치년 한국환경보건학회 2007 한국환경보건학회지 Vol.33 No.2

The range of reduction rates of airborne bacteria concentration at 6hrs, 12hrs, 24hrs and 48hrs, which means a storage time until input of agar media into incubator after air sampling with an impactor, were 15-20%, 25-40%, 35-50% and 55-70%, respectively, compared to initial concentration. Types of agar media and storage thermal condition did not significantly affect a collection efficiency of impactor in terms of evaluating airborne bacteria level (p>0.05). To better improve the impactor's collection efficiency of airborne bacteria, based on the result of this study, it is recommended that the vicinity of 25oC should be sustained until input of agar media into incubator after air sampling.

Styrene에 노출된 근로자의 요중 phenylglyoxylic acid와 postural body sway의 관련성

이경종,박재범,이규원,임광진,장규엽,방철우 大韓産業醫學會 2002 대한직업환경의학회지 Vol.14 No.4

목적 : 이 연구는 posturography를이용하여 만성 신경독성을 평가하여 국내에서 이 방법이 유기용제의 신경독성을 조기진단 할 수 있는 방법인지 styrene에 폭로된 근로자들을 통하여 평가하려는데 있다. 방법 : 1년 이상 styrene에 단일 폭로되는 36명의 남성 정화조 제조 근로자들을 연구 대상자로 하고, 15명의 자원한 병원 근로자들에 대하여 posturogrpahy 검사를 하여 비교하였다. 신체 규격을 측정하였고, 병력 및 직업력, 개인 생활습관 등의 정보를 설문을 통하여 얻었단. 정신적 문제, 당뇨병, 신경학적 장애, 보행 장애, 뇌졸중이 있는 경우는 실험 대상에서 제외하였다. 이들 두 군에서 sway area의 크기를 비교하였다. Sway area에 영향을 줄 수 있는 변수들을 통제하기 위하여 연령, 음주, 흡연, 체중, 신장, BMI등을 통제하였다. 결과 : 다중 회귀분석에서 폭로군에서의 평균 sway area는 다른 변수들을 통제한 후에도 대조군에 비하여 크게 관찰되었다. 결론 : Posturography는 우리 나라 에서 현재 TLV 수준 이하의 styrene에 폭로되는 무 증상의 근로자들에서 만성적 신경독성 영향을 평가하는데 유용할 수 있다고 판단된다. Objective: Until now, no effective screening tolls have been available for evaluationg the neurotoxicity of organic solvents and metals. The aim of this study was to evaluate the usefulness of posturographu as a screening tool for the chronic neurotoxicity of organic solvents. Method: 36 workers in 4 septic tank manufacturers, who were exposed to styrene over a period of 1 year (exposed group), and 15 hospital volunteer manual workers were examined by posturographu. The subjects' phusical, medical, and occupational characteristics were obtained by means of a phusical examination and a questionnaire. We excluded from both groups those persons who had psychiatric problems, diabetes, neurologic symptoms, gait disturbance, or a history of stroke. The sway area of the exposed group was compared to that of the non-exposed group using bivariate and multiple regression analusis. We controlled a number of variables including age, alcohol comsumption, smoking, weight, height, and body mass index. Results: The sway area of the exposed group was found to be higher than that of the non-exposed group after taking into consideration the effects of other characteristics by means of multiple regression analysis. Comclusion: We concluded the posturographu would be an effective tool for the screening of chronic neurotoxicity in workers expoosed to styrene.

도장 근로자의 작업 환경 만족도에 영향을 미치는 요인

노재훈,김치년,원종욱,임남구,장규엽,송재석 한국산업위생학회 1999 한국산업보건학회지 Vol.9 No.1

This study was performed to find out factors affecting degree of satisfaction with workers' working environment. The study subjects were 165 workers who were working at painting process of twelve furniture manufacturing factories in Incheon area. We used self-administered questionnaire containing general characteristics, working conditions, the degree of satisfaction with working environment, and the degree of satisfaction with working condition. In addition, we measured the exposure levels of occupational hazardous agents. The results were as follows; 1. Correlations between the degree of satisfaction with workers' working environment and the measured of occupational hazardous agents did not affect the degree of satisfaction with workers' working environment. 2. Factors affecting the degree of satisfaction with workers' working environment were not the exposure levels of occupational hazardous agents, but the degree of satisfaction with working condition, size of industry, health status, and types of ventilation system. As the degree of satisfaction with working condition was increased, the degree of satisfaction with working environment was increased. Also, for the workers who had good health status, the degree of satisfaction with work environment was appeared to be high. To increase the degree of satisfaction, with workers' working environment, firstly, effective work management and production control are required. Also, the worker's effort to negotiate continuously with top manager on improving working conditions is required. Secondly, developing heath promotion program to be appropriate for the characteristics of worksite is required. Moreover, leading worker's participation in health promotion program is very important to increase the degree of satisfaction with workers' working environment.

대공간 복사 냉난방 시스템과 저 엑서지(Exergy) 활용

이현종(Hyun-jong, Lee),장규엽(kyu-youb, Jang) 대한설비공학회 2019 대한설비공학회 학술발표대회논문집 Vol.2019 No.-

규제대상 다중이용시설내 부유세균의 분포 특성에 관한 현장 조사

김기연 ( Ki Youn Kim ),장규엽 ( Gyu Yeob Jang ),박재범 ( Jae Beom Park ),김치년 ( Chi Nyon Kim ),이경종 ( Kyung Jong Lee ) 한국산업위생학회 2006 한국산업보건학회지 Vol.16 No.1

Concentration and identification of airborne bacteria in the regulated public facilities were examined with the six-stage cascade impactor. Geometric mean total and respirable concentrations of airborne bacteria were 404 cfu/m3 and 194 cfu/m3 in hospital, 931 cfu/m3 and 358 cfu/m3 in kindergarten, 294 cfu/m3 and 134 cfu/m3 in day-care center, and 586 cfu/m3 and 254 cfu/m3 in postpartum nurse center, respectively. As a result, culturable total and respirable concentrations of airborne bacteria were significantly highest in kindergarten and lowest in day-care center (p<0.05). The ratio of respirable to total concentration of airborne bacteria in the investigated public facilities was ranged from 30% to 40% but there was no significant difference among them (p>0.05). The mean I/O ratio of culturable total and respirable concentrations were 0.58 and 0.66 in hospital, 0.71 and 0.83 in kindergarten, 0.28 and 0.41 in day-care center, and 0.63 and 0.78 in postpartum nurse center, respectively. Day-care center showed the lowest I/O ratio of culturable total and respirable concentration of airborne bacteria (p<0.05) but a significant difference was not found among other facilities. Indoor concentration of airborne bacteria did not correlated significantly with indoor temperature and relative humidity (p>0.05) but had a significant positive correlation with CO2 and surrounding condition (p<0.05). Staphylococcus spp., Micrococcus spp., Corynebacterium spp., and Bacillus spp. were dominant genera and amounted to over 95% of total airborne bacteria identified in the investigated public facilities. Size distributions of four dominant genera did not observed inconsistently regardless of type of public facility.

알코올 섭취가 소변 중 4-hydroxyproline 농도에 미치는 영향

이규원(Keou Weon Lee),이경종(Kyung Jong Lee),박재범(Jae Beom Park),장규엽(Kyu Yeub Jang),방철우(Chul Woo Bang),조영봉(Young Bong Cho) 한국항공우주의학협회 2003 항공우주의학회지 Vol.13 No.3

일개 대학병원 간호사의 교대근무와 수면장애와의 관련성

이정탁(Jung Tak Lee),이경종(Kyung Jong Lee),박재범(Jae Beom Park),이규원(Kyu Won Lee),장규엽(Kyu Yeob Jang) 대한직업환경의학회 2007 대한직업환경의학회지 Vol.19 No.3