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김명신 ( Myoung Shin Kim ),인승균 ( Seung Gyun In ),원종현 ( Chong Hyun Won ),장성은 ( Sung Eun Chang ),이미우 ( Mi Woo Lee ),최지호 ( Jee Ho Choi ),문기찬 ( Kee Chan Moon ) 대한피부과학회 2010 大韓皮膚科學會誌 Vol.48 No.5
Background: Cutaneous metastasis from an internal malignancy is uncommon and it usually arises from the breast and lung. Cutaneous metastasis from gastric cancer is rarely seen, although gastric cancer is the most common internal cancer in Korea. Objective: The purpose of this study was to analyze the clinical and histopathological characteristics of cutaneous metastasis from gastric cancer in Korea. Methods: Twenty-seven cases of cutaneous metastasis from gastric cancer were included in the study among the 14,053 patients who were diagnosed with gastric adenocarcinoma over a 20 year period. Their medical records and pathology slides were retrospectively reviewed. Results: The incidence of cutaneous metastasis was 0.19% (27/14,053). The age of the 27 patients ranged from 28 to 75, and the mean age was 53.9 with no significant difference in gender. The most frequently involved site was the abdomen followed by the face and scalp. Nodular lesion was most common (55.6%, 17/27) and inflammatory and indurated lesions were 25.9% (7/27) and 7.4% (2/27), respectively. Histopathologically, poorly differentiated adenocarcinoma (13/27) and signet-ring cell carcinoma (10/27) were common, which comprised 85.1% of the total tumor. In 7 cases (25.9%), skin lesion was the first presenting sign of gastric cancer or metastatic gastric cancer. The mean survival of the patients was 4.7 months. Conclusion: Cutaneous metastasis from gastric cancer is rare despite gastric cancer`s high prevalence as a primary cancer in Korea. It was frequently observed in patients with an advanced disease stage, yet it may represent the initial manifestation of the disease. Dermatologists can contribute to the management of patients with cutaneous metastasis by performing early detection and recognition of skin lesions. (Korean J Dermatol 2010;48(5):360~365)
박언재 ( Oun Jae Park ),인승균 ( Seung Gyun In ),강성민 ( Seong Min Kang ),홍승필 ( Seung Phil Hong ),박하나 ( Ha Na Bak ),원종현 ( Chong Hyun Won ),장성은 ( Sung Eun Chang ),이미우 ( Mi Woo Lee ),최지호 ( Jee Ho Choi ),문기찬 ( K 대한피부과학회 2010 대한피부과학회지 Vol.48 No.6
Adalimumab, a recombinant human IgG monoclonal antibody, selectively blocks tumor necrosis factor-alpha (TNF- α) and has been successfully used in the treatment of immune-mediated diseases. In particular, its efficacy has been proven in the treatment of rheumatoid arthritis, spondylarthritis, lymphoproliferative diseases and inflammatory bowel disease. Its use has also been studied for the treatment of psoriasis and yet, paradoxically, cases of new onset or exacerbation of psoriasis continue to increase in patients undergoing treatment with anti TNF-α agents. A 51-year-old woman had arthritis for a year and was diagnosed with psoriatic arthritis. After she had received adalimumab for psoriatic arthritis five times during one year, erythematous eruptions were found on her entire body. She then stopped adalimumab therapy for two months, although her skin lesions did not resolve. The patient was diagnosed with psoriasis through biopsy and began using cyclosporine, a topical steroid used for treatment of psoriasis. (Korean J Dermatol 2010;48(6):513∼516)
102명의 비흑색종 피부암 환자에 대한 Mohs 미세도식수술 치료 경험
양보희 ( Bo Hee Yang ),변지원 ( Ji Won Byun ),이승규 ( Seung Gyu Lee ),인승균 ( Seung Gyun In ),이현숙 ( Hyeon Sook Lee ),정기양 ( Kee Yang Chung ),신정현 ( Jeong Hyun Shin ),최광성 ( Gwang Seong Choi ),송희진 ( Hee Jin Song ) 대한피부과학회 2012 大韓皮膚科學會誌 Vol.50 No.11
Background: Mohs micrographic surgery (MMS) is a specialized type of minimal marginal surgery, which offers superior cure rates to other options in the treatment of non-melanoma skin cancers. Objective: The aim of this study is to investigate the clinical characteristics and recurrence rate of the non-melanoma skin cancer and to estimate the safeties of MMS. Methods: We retrospectively evaluated 102 patients who had been diagnosed with non-melanoma skin cancer and treated by MMS from May 2008 to September 2011. Results: The most common cancer was basal cell carcinoma (63.72%), followed by squamous cell carcinoma (31.38%). The local flap was the most common method to repair surgical defects (74.5%), followed by primary closure (17.64%). Cervical lymph node metastasis was confirmed in 1 case (0.98%). Recurrence after MMS was observed in 1 of 102 patients (0.98%). Conclusion: MMS is a safe method for the treatment of non-melanoma skin cancer. (Korean J Dermatol 2012;50(11):931∼936)
경구 Isotretinoin으로 빠른 호전을 보인 염증성표재성파종성한공각화증
양보희 ( Bo Hee Yang ),방찬일 ( Chan Yl Bang ),변지원 ( Ji Won Byun ),한성협 ( Sung Hyub Han ),송희진 ( Hee Jin Song ),인승균 ( Seung Gyun In ),최광성 ( Gwang Seong Choi ),신정현 ( Jeong Hyun Shin ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.7
Disseminated superficial porokeratosis is a keratinization disorder characterized by multiple brown, atrophic patches with sharply demarcated and hypertrophic ridges. Atypical cases of disseminated superficial porokeratosis with acute exacerbation accompanied by severe pruritus have been reported as eruptive pruritic papular porokeratosis or inflammatory disseminated superficial porokeratosis. We report a case of inflammatory disseminated superficial porokeratosis in a 53-year-old man who was successfully treated with oral isotretinoin.
양보희 ( Bo Hee Yang ),방찬일 ( Chan Yl Bang ),변지원 ( Ji Won Byun ),한성협 ( Sung Hyub Han ),송희진 ( Hee Jin Song ),인승균 ( Seung Gyun In ),신정현 ( Jeong Hyun Shin ),최광성 ( Gwang Seong Choi ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.2
Acantholytic squamous cell carcinoma is a well-defined, rare variant of squamous cell carcinoma in which significant portions of the neoplastic tissue show, on microscopy, a pseudoglandular or tubular pattern. It usually presents in aged patients as an erythematous nodule with scales, crust, and ulceration on sun-exposed areas. Herein we report a case of acantholytic squamous cell carcinoma that occurred on the Rt 4th toeweb of a 70-year-old man. (Korean J Dermatol 2011; 49(2):195~197)
Short Report : Acromegaloid Facial Appearance Syndrome with Generalized Hypertrichosis Terminalis
방찬일 ( Chan Yl Bang ),한성협 ( Sung Hyub Han ),변지원 ( Ji Won Byun ),양보희 ( Bo Hee Yang ),송희진 ( Hee Jin Song ),인승균 ( Seung Gyun In ),신정현 ( Jeong Hyun Shin ),최광성 ( Gwang Seong Choi ) 대한피부과학회 2011 大韓皮膚科學會誌 Vol.49 No.2
Acromegaloid facial appearance (AFA) syndrome is a rare autosomal dominant disease, consisting of an acromegaloid face, a bulbous nose, and narrowing of the palpaebral fissure. In 1996, Irvin first reported a case of a combination of acromegaloid facial appearance syndrome and congenital hypertrichosis, and reported this case as a new disease of acromegaloid facial appearance with generalized hypertrichosis terminalis, which is differentiated from both AFA syndrome and congenital hypertrichosis/gingival hyperplasia. We report herein the first Korean case of acromegaloid facial appearance with generalized hypertrichosis terminalis. (Korean J Dermatol 2011; 49(2):184~187)
인승균,임태균,윤성필,신정현,최광성 대한피부과학회 2004 대한피부과학회지 Vol.42 No.1
Acantholytic dyskeratosis is a regular histologic feature in Darier's disease, transient acantholytic dermatosis and warty dyskeratoma. It is also occasionally observed as an incidental histological finding in linear epidermal nevus. We report a case of acantholytic dyskeratotic epidermal nevus in an 11-month-old boy. The showed hyperkeratosis, irregular acanthosis & focal acantholytic dyskeratosis. (Korean J Dermatol 2004;42(1):87~89)
임태균,인승균,박정훈,최광성 대한피부과학회 2002 대한피부과학회지 Vol.40 No.8
Transient acantholytic dermatosis was first described by Grover in 1970. It is characterized by pruritic, discrete papules and papulovesicles distributed mainly on the trunk. The histologic hallmark of the disorder is focal acantholysis, several patterns of which have been described. The etiologic factors and pathogenesis remain unclear. We report a 45-year-old male patient with multiple severely pruritic, discrete papules and papulovesicles on the trunk, There were no oral cavity, palm and sole involvement. Histopathologic findings revealed epidermal acanthosis, acantholysis and hyperkeratosis with suprabasal splits. He showed good response to topical steroid and oral antihistamine.
이승규,인승균,신정현,최광성,윤성필 대한피부과학회 2003 대한피부과학회지 Vol.41 No.12
Erythema elevatum diutinum(EED) is a rare chronic skin disease characterized by red, purple, and yellowish papules, plaques, and nodules that are usually distributed acrally and symmetrically over extensor surface. It is characterized histologically by a leukocytoclastic vasculitis. Although no trea-tment has shown a complete response, dapsone is reported to be effective to EED. We report a rare severe case of EED with good response to dapsone treatment. (Korean J Dermatol 2003;;41(12):1683~1685)