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변지원 ( Ji Won Byun ),송희진 ( Hee Jin Song ),최광성 ( Gwang Seong Choi ),신정현 ( Jeong Hyun Shin ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.4
Background: Herpes zoster meningoencephalitis is a rare neurological complication and the known risk factors include an immunocompromised status, infiltration into the trigeminal ganglion, disseminated herpes zoster and elderly patients. Serious complications may develop, including cerebral hemorrhage. Objective: As early diagnostic detection is mandatory to prevent long-term sequelae, we wanted to determine what signs and symptoms we should focus on for diagnosing zoster meningoencephalitis at an early stage. We also investigated the descriptive statistics of the patients and compared them with the patients who had non-complicated herpes zoster. Methods: We examined the medical records of 5114 herpes zoster patients who had visited our clinic from 1996 through 2009. Among them, 18 patients who were diagnosed with herpes zoster meningoencephalitis by cerebrospinal fluid tests were subject to examinations to assess the incidence rates, the age distribution, the ganglion distribution, the clinical aspects, the underlying diseases and the presence of complications. Results: The ages of the patients with herpes zoster meningoencephalitis showed that 50% of the patients were under 30 years old. Infiltration into the trigeminal ganglion and immunocompromising underlying diseases accounted for 50% and 16.7% of the total patients, respectively. In the case of disseminated herpes zoster patients, no meningoencephalitis developed. The rates of neck stiffness and fever, which are the most common symptoms of meningoencephalitis, were lower in the patients with herpes zoster meningoencephalitis (33.3% and 11.1%, respectively). However, headaches accompanied with nausea or vomiting showed high sensitivity (88.9%), and a high positive predictive value (69.6%) (p<0.001). All the patients were treated with acyclovir for 10∼14 days, and cerebral hemorrhage occurred in 1 of them (5.5%) after treatment. Conclusion: When a patient with herpes zoster has symptoms of headache and nausea or vomiting then herpes zoster meningoencephalitis should be considered even if neck stiffness and fever are not present. (Korean J Dermatol 2011;49(4):328∼333)
변지원 ( Ji Won Byun ),양보희 ( Bo Hee Yang ),한성협 ( Sung Hyub Han ),송희진 ( Hee Jin Song ),이현숙 ( Hyeon Sook Lee ),최광성 ( Gwang Seong Choi ),신정현 ( Jeong Hyun Shin ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.3
Pruritic urticarial papules and plaques of pregnancy (PUPPP), also known as a polymorphic eruption of pregnancy, is the most common dermatosis of pregnancy. Typically, PUPPP starts with erythema and urticarial papular eruption in the abdominal striae and may extend to the buttocks and thighs. It usually evolves in the third trimester and resolves rapidly in the postpartum. It is not usually recurrent in subsequent pregnancies. We report herein two patients with postpartum PUPPP. (Korean J Dermatol 2010;48(3):228~231)
변지원 ( Ji Won Byun ),양보희 ( Bo Hee Yang ),한성협 ( Sung Hyub Han ),송희진 ( Hee Jin Song ),신정현 ( Jeong Hyun Shin ),최광성 ( Gwang Seong Choi ),이현숙 ( Hyeon Sook Lee ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.2
Malalignment of the toenail is a rare deformity that is characterized by lateral deviation of the nail plate with respect to the longitudinal axis of the distal phalanx. The condition may be congenital or acquired. The acquired forms of malalignment may result from trauma or surgical intervention. However, there are only a few reports that have focused on surgical treatment for this condition. We present here a case of a 24-year-old woman who had this nail problem for 1 year and she was successfully treated with the surgical approach. We also discuss the probable mechanism of iatrogenic malalignment. (Korean J Dermatol 2010;48(2):148∼151)
에이퍼트 증후군에서 Isotretinoin로 치료한 난치성 여드름 1예
변지원 ( Ji Won Byun ),한성협 ( Sung Hyub Han ),양보희 ( Bo Hee Yang ),송희진 ( Hee Jin Song ),이현숙 ( Hyeon Sook Lee ),이승규 ( Seung Gyu Lee ),신정현 ( Jeong Hyun Shin ),최광성 ( Gwang Seong Choi ) 大韓皮膚科學會 2009 大韓皮膚科學會誌 Vol.47 No.10
Apert syndrome is a rare genetic craniofacial disorder associated with premature fusion of multiple cranial sutures and syndactyly. It is caused by mutation in the fibroblast growth factor receptor 2 genes. The clinical findings are characterized by the typical dysmorphic facial features, including hypertelorism, proptosis and cleft palate. Most of these patients have widespread, severe acne involving the face, chest, back and forearms during puberty and the acne is unresponsive to conventional treatments. We report here on a patient with the recalcitrant acne of Apert syndrome and the patient had failed to respond to conventional acne treatment, but the acne was successfully treated with isotretinoin. (Korean J Dermatol 2009;47(10):1196∼1198)
변지원 ( Ji Won Byun ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
The tissue is incised with a #15 blade at a 45°angle from horizontal, beginning approximately 2mm around the cancer. Necks are made in the surrounding tissue to denote tissue orientation and mapping. In some cases, double nicks can help in the orientation of the tissue. Mapping of the tissue is a crucial step in MMS. The topographic map allows the Mohs surgeon to relate the microscopic findings to the excised tissue and the anatomic reference points at the surgical site. The Mohs map is typically created by drawing freehand, using a template. The tissue is brought to the adjacent laboratory (pathology). Color coding of specimens is critical. The Mohs technician or the surgeon marks the borders of the tissue with different colors to allow orientation relative to the Mohs map. Usually two dyes are used such as blue, yellow, or green. The tissue is then processed by a technician. The tissue is frozen and is cut horizontally on a microtome. In contrast to traditional paraffin section, which are cut vertically (bread-loaf sections), the Mohs sections theoretically allows 100% of the tumor margins (depth and periphery) to be examined. Most Mohs surgeons use hematoxylin-eosin stain (84%) and minority use toluidine blue as the preferred stain.
황혜원 ( Hye Won Hwang ),이선복 ( Seon Bok Lee ),허지혜 ( Ji Hye Heo ),신정현 ( Jeonghyun Shin ),최광성 ( Gwang Seong Choi ),변지원 ( Ji Won Byun ) 대한피부과학회 2021 대한피부과학회지 Vol.59 No.2
Syringoid eccrine carcinoma (SEC) is a rare cutaneous malignant tumor thought to be derived from eccrine sweat glands. It is usually present in the scalp and face and often occurs in the fourth to seventh decades of life. A 76-year-old female patient visited our department with a 3-year history of a lesion showing a 5×4 cm-sized erythematous firm plaque with ulceration on her right shoulder. Histological findings revealed a tumor consisting of numerous proliferating tubular structures with two layers of basaloid cells with cellular atypia. Some ductal structures showed a tadpole appearance. Based on these findings, the final diagnosis was SEC. The patient was treated with slow Mohs micrographic surgery and a full-thickness skin graft and did not show any recurrence during the follow-up period of 6 months. Herein, we report a very rare case of a 76-year-old woman diagnosed with SEC that developed on the right shoulder. (Korean J Dermatol 2021;59(2):136∼139)
강민지 ( Min Ji Kang ),변지원 ( Ji Won Byun ),신정현 ( Jeong Hyun Shin ),황승식 ( Seung Sik Hwang ),최광성 ( Gwang Seong Choi ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.11
Background: Androgenetic alopecia (AGA) is the most common type of hair loss, and androgens and genetic predisposition are believed to be the major factors that influence the development of AGA. Although there have been previous reports about the relationship between family history, smoking and insulin resistance with AGA, no previous study has investigated lifestyle habits such as eating habits in AGA patients Objective: The aim of this study was to investigate family history, lifestyle including smoking and eating habits in AGA patients and to compare the results with data from Korea Health Statistics 2009: Korea National Health and Nutrition Examination Survey (KNHANESIV-3). Methods: We retrospectively evaluated a total of 347 male patients with AGA who visited the Department of dermatology, Inha University School of medicine, from September 2010 to August 2012. Results: AGA with paternal family history was the most common (49.9%), and both of maternal and paternal family history was the least (10.1%). Body mass index and smoking did not show significant differences but eating habits showed a statistically significant difference according to the duration of AGA. Patients with longer disease duration (≥60 months) showed higher intake of meat but low intake of fish than those with shorter disease duration (<12 months). Also, AGA patients showed low intake of beef, bean and squid in comparison to the average Korean population. Conclusion: This was the first study which investigated lifestyle habits such as eating habits in AGA patients and compared the results with data from Korea Health Statistics. However, a further large scale Cohort study is needed to define the casual relationship between eating habits and the development of AGA. Also, a further study including the difference of serum and hair androgen levels in relation to different lifestyle habits should be done. (Korean J Dermatol 2013;51(11):878∼884)