추계학술대회 : 지상발표부 ; 연세의대 : 한국 남자 대학생들의 여름철 피부색 변화에 관한 연구

이해을,조정구,이성낙 대한피부과학회 1983 대한피부과학회 학술발표대회집 Vol.35 No.2

춘계학술대회 : 구연부 ; 양성종양(2) : Eccrine Spiradenoma 1예

이해을,방동식 대한피부과학회 1983 대한피부과학회 학술발표대회집 Vol.35 No.1

Acinic Cell Tumor

이해을(Hae Eul Lee),방동식(Dong Sik Bang),이정복(Jung Bock Lee) 대한피부과학회 1983 대한피부과학회지 Vol.21 No.2

Acinic cell tumor, a rare tumor of the salivary gland origin, consists of cells similar to the serous cells of the salivary gland. The tumor is almost exclusively paroti4 gland origin, accounting for 2. 7 to 4. 0% of all parotid tumors. The tumor is not ,benign but has at least a low-grade malignant potential. We described herein a case of acinic cell tumor which had occurred on an unusual site, right inner epicanthal area of a 9-year-old girl Microscopically, a hematoxylin-eosin stained biopsy specimen showed rnany lobules com of round or polyhedral tumor cells. Each tumor cell had distinct cell membrane, clear cytoplasm, and relative1y eccentric nucleus. The cytoplasm of tumor cell cantaine4 diastase resistant PAS-positive material.

아토피피부염 환자에서 유성 온천수를 이용한 온천욕의 보조적 치료 효과와 안전성에 대한 연구

이해을 ( Hae Eul Lee ),김형래 ( Hyeong Rae Kim ),임명 ( Myung Im ),이영 ( Young Lee ),김창덕 ( Chang Deok Kim ),이증훈 ( Jeung Hoon Lee ),서영준 ( Young Joon Seo ) 대한피부과학회 2014 대한피부과학회지 Vol.52 No.2

Background: Long-term use of various topical and systemic therapies for atopic dermatitis is associated with cutaneous and systemic adverse effects. Balneotherapy as an adjuvant treatment for atopic dermatitis has been extensively studied, and is considered effective and safe, in many countries. However, there is limited evidence from Korea, with only one previous report on the subject. Objective: The aim of this study was to investigate the therapeutic efficacy and safety of balneotherapy in the treatment of atopic dermatitis in a Korean population. Methods: Thirty atopic dermatitis patients were included in this randomized clinical trial evaluating the therapeutic efficacy of balneotherapy at Yuseong Spa, for four weeks. The patients were assigned to two groups: the control group (allowed treatment only) and balneotherapy group (additionally treated with balneotherapy). Assessment was made at baseline, and after 1, 2, and 4 weeks of treatment. Results: At week 4, compared with the control group, the balneotherapy group showed significantly greater improvement in the eczema area and severity index score, physician`s global assessment, patient`s self global assessment, and in the measured value of transepidermal water loss. The visual analog scale for pruritus in the balneotherapy group decreased, whereas it increased in the control group. None of the patients experienced any adverse events. Conclusion: Our study suggests that balneotherapy may be beneficial, is safe, and may increase the quality of life for patients with atopic dermatitis.

Appendageal tumor, tumor of melanocyte, tumor of dermis and subcutaneous fat and cutaneous lymphoma

이해을 ( Hae Eul Lee ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

1. Appendageal tumor 1) Follicular neoplasms ·Pilomatricoma: associated with activating mutations in β-catenin Multiple lesions → Gardner’s syndrome, myotonic dystrophy, Rubinstein-Taybi, Turner syndrome ·Proliferating trichilemmal tumor: derive from the outer root or trichilemmal sheath & present on the scalp of elderly individuals (female predominance) ·Birt-Hogg Dube syndrome: FLCN gene mutation (autosomal dominant) 2) Sebaceous neoplasms ·Nevus sebaceous: most commonly on scalp Development of secondary neoplasms → syringocystadenoma papilliferum, trichoblastoma, basal cell carcinoma Low risk of malignancy → treatment is primarily cosmetic ·Sebaceous adenoma & sebaceoma ·Muir-Torre syndrome: Germ-line mutation in the DNA mismatch repair genes, MSH2, MLH1, MSH6 (autosomal dominant) Sebaceous neoplasms (m/c:sebaceous adenoma), keratoacanthoma, internal malignancy(m/c: colon cancer) ·Sebaceous carcinoma: typically on the eyelids of elderly individuals 3) Eccrine neoplasms ·Syringoma (adult females), Chondroid syringoma (middle-aged and elderly males) ·Eccrine poroma: palms and soles of adults ·Nodular hidradenoma: scalp, face, trunk in middle-aged and elderly females 4) Apocrine neoplasms ·Hidradenoma papilliferum: small nodule on female vulva ·Syringocystadenoma papilliferum: present at birth or early childhood on scalp ·Cylindroma: usually on scalp in females 2. Tumor of melanocyte 1) Congenital nevomelanocytic nevi (CNN) ·Cranial or midline large CNN and large CNN with satellite lesions: increased risk of neurocutaneous/leptomeningeal involvement → MRI may be indicated 2) Spitz nevus: activating mutations of H-RAS 3) Dysplastic nevus 4) Malignant melanoma ·ABCD checklist: A(asymmetry), B(border irregularity), C(color variegation), D(diameter> 6mm, difference: “ugly duckling” sign), E(evolving over time) 3. Tumor of dermis and subcutaneous fat 1) Fibrous, fibrohistiocytic and histiocytic tumors 2) Vascular tumors ·Infantile hemangioma: expression of GLUT-1 Propranolol treatment → vasoconstriction, inhibition of angiogenesis, induction of apoptosis ·Kasabach-Merritt phenomenon: complication of tufted angioma and kaposiform hemangioendothelioma → tender, expanding vascular tumor with thrombocytopenia (usually severe) 3) Neoplasias and hyperplasias of muscular and neural origin 4) Neoplasms of subcutaneous fat 5) Kaposi’s sarcoma (KS): invariably linked with HHV-8 infection ·Classical KS: in old men, starts as localized form and progresses slowly 6) Angiosarcoma: highly malignant vascular tumor ·Primary angiosarcoma (elderly on head, neck, face) / Angiosarcoma in areas of chronic lymphedema / Postirradiation angiosarcoma 4. Cutaneous lymphoma 1) Cutaneous T-cell and NK-cell lymphomas ·Mycosis fungoides (MF) ·MF variants and subtypes (folliculotrophic MF, Pagetoid reticulosis, Granulomatous slack skin) ·Sezary syndrome ·Adult T-cell leukemia/lymphoma ·Primary cutaneous CD30-positive lymphoproliferative disorders (Primary cutaneous anaplstic large-cell lymphoma, Lymphomatoid papulosis) ·Subcutaneous panniculitis-like T-cell lymphoma ·Extra-nodal NK/T-cell lymphoma, nasal type ·Primary cutaneous peripheral T-cell lymphoma, unspecified (Primary cutaneous aggressive epidermotrophic CD8+ T-cell lymphoma, Cutaneous γ/δ T-cell lymphoma, Primary cutaneous CD4+ small or medium-sized pleomorphic T-cell lymphoma) 2) Cutaneous B-cell lymphomas ·Primary cutaneous marginal zone B-cell lymphoma ·Primary cutaneous follicle center lymphoma ·Primary cutaneous diffuse large B-cell lymphoma, leg type ·Primary cutaneous diffuse large B-cell lymphoma, other ·Precursor hematologic neoplasm ·CD4+/CD56+ hematodermic neoplasm (blastic NK-cell lymphoma)

한국남자 대학생들의 여름철 피부색 변화에 관한 연구

이해을(Hae Eul Lee),조정구(Chung Koo Cho),이성낙(Sung Nack Lee) 대한피부과학회 1984 대한피부과학회지 Vol.22 No.2

This study was undertaken to clarify whether the color changes of skin in summer are remarkable or not. The skin color of abdomen, extensor and flexor of forearm, forehead, and cheek were measured in 27 health male students who had never tanned their skin intentionally during this experiment with Color and Color Difference Meter(Nippon Denshoku Kogyo Ca. CP6R 1001-DP) which represents skin color as 'L', 'a', and 'b' values. The 'L', 'a', and 'b' values mean the degree of lightness, redness, and yellowness respectively. Measurements had been performed four times repeatedly from summer(june) to auturmn(October) with intervals of 6 weeks. The obtained values were evaluated with statistical method, and the results were sumrnarized as follows: l. Abdominal skin showed no significant color changes in this experiment. 2 Extensor and flexor skin of forearm showed significant decrease in lightness from July, and the degree of decrease was more remarkable on extensor skin than on flexor skin. The lighteness had not been recovered by October on extensor skin and by September on flexor skin. There was no significant change in redness and yellowness on both places in this experiment. 3. Forehead skin showed no significant change in lightness and yellowness in this experiment, and showed transient decrease in redness in July. 4. Cheek skin showed no significant change in lighteness and redness in this experiment, and showed transient increase in yellowness in October.

진균감염질환(眞菌感染疾患) : 스테로이드제제(製劑)의 국소도포(局所塗布)로 악화(惡化)된 개선(疥癬) 및 백선증(白癬症) 1예(例)

황경희,이해을,강원형,고창조,조정구 대한피부과학회 1981 대한피부과학회 학술발표대회집 Vol.33 No.1

춘계학술대회 : 미분류된 조직구증(Unclassified histiocytosis) 1예

한신원,이해을,김덕현,조정구 대한피부과학회 1984 대한피부과학회 학술발표대회집 Vol.36 No.1

Pedunculated Lipofibroma : The solitary Form of Nevus Lipomatosus Superficialis

윤경한,이해을,장승남,김동근 대한피부과학회 1996 Annals of Dermatology Vol.8 No.1

A 45-year-old woman had a bean-sized, asymptomatic, soft nodule on the right buttock for 4 years. Histopathologic evaluation revealed acanthosis and a central core of adipose tissue with thin papillary and reticular dermis containing eccrine glands. Staining with alcian blue showed a slight increase of mucopolysaccharides in the reticular dermis. We made the diagnosis of pedunculated lipofibroma as a solitary form of nevus lipomatosus superficialis.

Mibelli형 땀구멍각화증에서 치료 중 발생한 편평세포암

김형래,임초아,이해을,임명,이영,이증훈,서영준 대한피부과학회 2017 大韓皮膚科學會誌 Vol.55 No.3

땀구멍각화증은 표피의 각화 이상에 의하여 발생하는 피부질환으로 임상적으로 원심성으로 퍼저나가는 경계부가 융기된 형태의 윤상 판으로 나타나며 조직학적으로 뿔층판(cornoid lamellae)이 특징적으로 관찰되는 질환이다¹.환자는 80세 여자 환자로 13년 전부터 발견한 좌측 무릎의 6×7 cm 크기의 홍반인설성 판을 주소로 5년 전 내원하였으며, 조직검사 후 Mibelli형 땀구멍각화증으로 진단하였다(Fig. 1A∼C). 이후 국소 Tretinoin, 국소 스테로이드, 국소 Tacrolimus, 국소 Calcipotriol, CO2 레이저, 경구Acitretin 등을 사용하였으나 병변의 부분적인 호전만을 보였다. 2년 전부터 병변부로 반복되는 미란과 궤양이 발생하여 경구 Cefadroxil 및 fusidate 연고 도포와 foam dressing을 실시하였으나 일시적 호전후 반복적인 재발을 보였다. 1년 전부터는 해당부위로 종괴가 발생하여 절제생검 및 단순봉합을 시행하였다(Fig. 1D). 종괴부위에서 시행한 조직검사상 잘 분화된(well-differentiated) 호산성의 세포질을 갖는 비정형세포들이 하부 진피층까지 깊게 침윤되어있는 것을 확인할 수 있었다(Fig. 1E, F). 조직검사 소견을 바탕으로 땀구멍각화증에서 발생한 편평세포암으로 진단하였으며, 절제수술 후 16개월간 재발의 증거 없이 경과관찰 중이다. 땀구멍각화증은 Mibelli형, 파종얕은광선땀구멍각화증, 손발바닥파종땀구멍각화증, 선땀구멍각화증, 점땀구멍각화증 등의 아형이 존재하며 점땀구멍각화증을 제외한 모든 아형에서 악성변화가 나타날 수 있음이 알려져 있다¹. 악성 피부병변 발생률은 7∼11%로 추정되며, 그 중 편평세포암이 가장 흔하게 발생하며, 일부에서 보웬병, 기저세포암이 발생할 수 있다^1-4. Mibelli형 땀구멍각화증의 경우 현재까지 국내 문헌에는 총 3예의 편평세포암이 보고된 바있다(Table 1). Shu 등²과 Cho 등³이 보고한 증례의 경우 내원 시 이미 종괴가 땀구멍각화증과 같이 동반되어 있었으며, 원 등⁴은 원저 내에 포함된 증례로 악성변화가 발생한 시점과 땀구멍각화증 진단 이후 어떠한 치료를 하였는지 확인할 수 없었다. 본 증례의 경우 악성 변화 발생 전본원 외래에 내원하여 땀구멍각화증을 진단하였으며, 이후 4년간 추적 관찰하며 치료를 하였음에도 불구하고 악성변화를 경험한 경우로 이에 흥미로운 증례로 생각된다. 땀구멍각화증의 치료로는 외과적 절제, 냉동치료, 레이저 소작, 광역동치료, Vitamin D 유도체, 5-fluorouracil, imiquimoid 크림, diclofenac 겔, 국소 또는 경구 레티노이드, Tacrolimus 연고 등이 사용되나, 광선각화증이나 지루각화증에 비하여 근치가 어렵다^1,5. 본 증례의 경우 종괴 발생전까지 약 4년간 간의 치료기간 동안 다양한 국소치료제와 경구 레티노이드 및 CO2 레이저를 1회 시행하였으나 근치에 실패하였고 병변내의 악성전환을 경험하였다. 땀구멍각화증이 진단된 경우 악성화 이전에 병변의 보다 적극적 치료가 필요할 것으로 생각되며, 추적관찰 시 지속되는 궤양이나 종괴가 발생하는 경우에는 반드시 조직검사를 시행하여 악성변화를 확인하는 것이 필수적일 것으로 생각된다. 이상으로 저자들은 Mibelli형 땀구멍각화증에서 치료 도중 발생한 편평세포암 1례를 경험하고 흥미롭고 교육적인 증례라 생각하여 문헌 고찰과 함께 보고하는 바이다.