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허용,유환국,안욱수,김병열,이정호,유회성,Hur, Y.,Yu, H.K.,Ahn, W.S.,Kim, B.Y.,Lee, J.H.,Yu, H.S. 대한흉부심장혈관외과학회 1990 Journal of Chest Surgery (J Chest Surg) Vol.23 No.1
A total of 129 patients with a confirmed diagnosis of primary lung cancer were treated at Dep. of Thoracic k Cardiovascular Surgery, National Medical Center, Seoul, Korea, between July, 1981 and Dec., 1988. Particular emphasis was given in this review to the 72 patients that underwent surgical resection of their primary lung lesion. Factors such as histology, type of resection, sex, age, staging, and degree of dissemination were considered possible influences on survival. The age group of fifty k sixty decade occupied 55.8 %, and the youngest being 24 years and oldest 78 years. The incidence ratio of male to female was 3,2:1. The subjective symptoms of the patients were coughing [72.6%], chest pain [48.2%] and hemoptysis [35.6%], which were due to primary local influence. The confirmed diagnostic procedures were bronchoscopic biopsy, sputum cytology needle aspiration biopsy, open lung biopsy, anterior mediastinotomy & lymph node biopsy. By pathologic classifications, the squamous cell carcinoma was the most prevalent, 67 cases [51.9 %], and the adenocarcinoma in 36 cases [27.9%], undifferentiated small cell carcinoma in 13 cases [10.1 %], undifferentiated large cell carcinoma in 9 cases [6.9%], bronchioloalveolar carcinoma was 4 cases [3.1%]. The lymph node dissection with pneumonectomy [42 cases], lobectomy [14 cases] and pneumonectomy [6 cases], lobectomy [9 cases] without lymph node dissection were performed. The post operative TNM Staging[AJC] in 72 cases were Stage I in 24 cases, Stage II in 27 cases, and Stage III in 21 cases. Overall resectable was possible in 72 cases [55.8 %], and the operation mortality was 5.6 % [4 cases].
허용,이상목,이섭,유환국,안욱수,김병열,이정호,유회성,Hur, Y.,Lee, S.M.,Lee, S.,Yu, H.K.,Ahn, W.S.,Kim, B.Y.,Lee, J.H.,Yu, H.S 대한흉부심장혈관외과학회 1991 Journal of Chest Surgery (J Chest Surg) Vol.24 No.10
Congenital cysts of the mediastinum are rare, but interesting lesions. Such cysts are important because they may produce distressing symptoms and because some have a malignant potential. Mediastinal cysts of foregut origin represent an important diagnostic group. Classified according to their anomalous embryonic origins they include pericardial, bronchogenic, esophageal, enteric, and nonspecific cysts. A series of 11 consecutive surgically treated cases from the Dep. of Thoracic & Cardiovascular Surgery in National Medical Center from Oct. 1959 to Dec. 1990, all successfully resolved without mortality. The 8 bronchogenic, 1 enteric, & 2 non specific cysts are included in this series. And 2 of 11 were asymptomatic patients presented. The clinical & pathological behavior of the individual cysts comprise a wide variety of patterns. Proper utilization of the many diagnostic tests available can accurately characterize the cysts. The exact histologic diagnosis, however, is rarely made prior to operation.
박유환(Y .H .Park),정춘혜(C .H .Chung),조영신(Y .S .Cho),김동규(D .G .Kim),손현화(H .H .Son),서영선(Y .S .Seo),이미자(M .J .Lee) 대한내과학회 2000 대한내과학회지 Vol.58 No.5
N/A Background : The role of oncogenes and tumor suppressor genes in the pathogenesis of gastric carcinoma has recently received considerable attention. The tumor suppressor gene, p53 locus on chromosome 17p, ceases a mitosis in G1/S check point after DNA demage. Abnormality of the p53 tumor suppressor gene plays an important role in alteration of cells and possibly leads to cancer development. The authors investigated the correlation between expression of p53 and prognosis in advanced gastric carcinoma. Methods : Expression of tumor suppresor gene p53 was investigated immunohistochemically in the primary lesion of 34 patients with advanced gastric carcinoma using paraffin embedded surgical specimens and the relationship of p53 immunopositivity with the clinicopathologic variables(Age, Sex, TNM staging, Lauren classification, Borrmann classification), 5-year survivals and life curves were analyzed. Kaplan and Meier's method is used as a life curve and log crank method is used for the analysis of prognostic factor. Results : Total p53 positive rate was 53% (18 of 34) of all cases. p53 immunopositivity was not associated with other clinicopathologic variables. The 5-year survivals were 44% and 11% for patients with p53 negative and positive gastric carcinomas, respectively. Patents with the expression of p53 has predominantly poor results in comparison of life curve(p<0.05) Conclusion : These findings suggest that p53 gene alteration be associated with poor prognosis of advanced gastric adenocarcinoma(Korean J Med 58:568-574, 2000)