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랫드에서 매미눈꽃동충하초 , Paecilomyces sinclairii의 13주 반복투여 독성에 관한 연구
안미영(Mi Young Ahn),지상덕(Sang Duk Jee),김지염(Ji Young Kim),한재웅(Jea Woong Han),이용기(Yong Ki Lee),이용우(Yong Woo Lee),류강선(Kang Sun Ryu),이병무(Byung Mu Lee),정나진(Na Jin Jung),김성남(Sung Nam Kim) 한국독성학회 2004 Toxicological Research Vol.20 No.4
Paecilomyces sinclairii was administered ad libitum feeding at percentage levels of 0, 1.25, 2.5, 5 and 10 percentage (calculated about 8 g/kg)/feeder for a period of 3 months. There was no observed clinical signs or deaths related to treatment in all groups tested. Therefore, the approximate lethal dose of P. sinclairii was considered to be higher than 8 g/kg in rats. Mild decreases in body weight gain were observed dose-dependently in P. sinclairii treated groups in dose response manner after 2 weeks. Interestingly, the weight of abdominal adipose tissues surrounding epididymides were greatly reduced by this Dongchunghacho, in parallel with the mild increase in body weight gain. However, the absolute weight change of other organs was not observed. There were not significantly different from the control group in urinalysis, ocular examination, hematological, serum biochemical value and histopathological examination. From these results, it is concluded that the no-observedadverse-effect level (NOAEL) of P. sinclairii is less than 1.25% (1 g/kg) in rats in the present study.
증례보고 : 정맥-정맥 체외막산소공급 보조 하에 시행한 기도 수술의 마취 3례
이용기 ( Yong Ki Lee ),박상헌 ( Sang Hyun Park ),황진영 ( Jin Young Hwang ),류춘근 ( Choon Gun Ryu ),김진희 ( Jin Hee Kim ),한성희 ( Sung Hee Han ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.57 No.4
The airway management for patients with critical airway problems continues to be a challenge to the anesthesiologist. In general cases, conventional ventilation techniques have been used successfully. These include fiberoptic bronchoscope guided intubation, supraglottic airway, endotracheal or endobronchial intubation at operative field, high frequency jet ventilation, etc. However, patients with near-fatal airway obstruction or severely depressed pulmonary function that is refractory to conventional ventilation methods also present. In these cases, cardiopulmonary bypass or extracorporeal membrane oxygenation (ECMO) can be used. Although these situations are uncommon indications for ECMO, ECMO can be a potential option for these life threatening conditions. Especially, venovenous (VV) ECMO can be used for pure pulmonary support. We describe three cases of airway surgery requiring ECMO. VV ECMO was established in all cases. ECMO provided adequate temporary pulmonary support and all patients weaned from ECMO successfully without any complication. (Korean J Anesthesiol 2009;57:522∼7)
소아 환자에서 방사선 차폐체로 인한 피폭선량과 화질의 변화
이영희(Young-Hee Lee),이용기(Yong-Ki Lee) 한국방사선학회 2020 한국방사선학회 논문지 Vol.14 No.7
본 연구는 자동노출선량장치을 사용했을 때 생식선 차폐체의 유무와 크기 변화에 따른 소아 환자의 방사선 피폭선량과 화질의 변화를 관찰하기 위하여 수행되었다. X-ray 장비를 이용하여 소아 팬텀의 복부와 생식선에서 차폐체가 없을 때와 3가지 크기의 차폐체를 사용했을 때의 방사선 피폭선량을 측정하였으며, 얻어진 영상을 통하여 SNR과 CNR을 측정하였다. 연구 결과 방사선 차폐체의 크기에 비례하여 생식선의 방사선 피폭선량은 감소하였으나 복부의 방사선 피폭선량은 오히려 증가되는 것으로 나타났으며 화질의 변화는 나타나지 않았다. AEC System 사용으로 인하여 방사선 차폐체로 인하여 증가된 방사선으로 인하여 과 피폭되지 않도록 소아 환자의 연령과 몸무게, 신체 크기에 최적화된 크기의 차폐체를 사용하는 것이 효과적이라는 것을 확인할 수 있었다. This study was conducted to observe the changes in radiation exposure dose and image quality of pediatric patients according to the presence and size of the gonadal shield when using the AEC system. X-ray equipment was used to measure the radiation exposure dose in the abdominal and gonads of the pediatric phantom when no shielding body was used and when three different sizes of shielding body were used, and SNR and CNR were measured through the obtained images. As a result of the study, the radiation exposure dose to the gonads decreased in proportion to the size of the radiation shield, but the radiation exposure dose to the abdomen was rather increased, and the image quality did not change. It is recommended to use a shield with a size optimized for the age, weight, and body size of the pediatric patient so as not to be overexposed by the increased radiation due to the radiation shield due to the use of the AEC System. For this purpose, information about the pediatric patient with the nurse It is believed that exchange is necessary.