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Halothane 마취후 발생한 간괴사 13예의 임상적 고찰
이용구(Y K Lee),김학철(H C Kim),조원섭(W S Cho),조정구(C G Cho) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.1
N/A There were many controversies concerning halothane-induced hepatitis, but a few cases suggest there was clinical, historical, biochemical, immunologial and epidermiological evidence to support theory of halothane induced hepatitis. We described 13 cases who had otherwise unexplained hepatitis after halothane anesthesia. The clinical features and complications were similar to those of any other severe hepatitis, but some differences were noticed. We obtained the results as followings; 1) The most common clinical symptom was high fever, which was noticed in 12 of the 13 cases, and it occurred between the 4th to 16th postoperative day, and its duration was variable, but ranging from 3 to 10 days. 2) The other clinical symptoms were non-specific G-I symptoms, myalgia, headache, easy fatigue and jaundice. And constitiutional prodromal symptoms were developed during or after the post-febrile period, but gradually subsided after the onset of clinical jaundice. 3) Abnormal laboratory findings, espicially AST and ALT, showed a variable increase during the onset of the febrile period or at its conclusion. The peak levels of serum aminotransferases were noticed at the end of febrile period, or the post-febrile period and they gradually normalized after 3 to 6 weeks in the most of the cases. 4) The relative frequency of the unexplained hepatitis was observed as follows; in the 13 cases; above the umbilicus of the operaive site (9), hypotension during operation (8), previous history of surgery under general anesthesia (4), obesity (5). And the fatality rate was 15.1% (2), these two cases showed a prolongation of the prothrombin time 8 seconds over the normal control time.
김민영(M.Y. Kim),이용구(Y.G Lee),김윤년(Y.N. Kim),남창욱(C.W Nam),허윤석(Y.S.Heo) 대한기계학회 2015 대한기계학회 춘추학술대회 Vol.2015 No.11
Aortic dissection is a medical emergency situation requiring quick and proper treatments, otherwise patient can suddenly lead to death as a result of rupture of the aorta. The rupture can be triggered by many factors such as blood pressure, velocity, viscosity etc. and it is critical for patients to manage the internal and external factors acting on the blood vessels before the rupture begins. To control the factor like blood pressure, we need to set a threshold value for the safe zone for each patient to provide proper treatment guidelines. This important threshold can be obtained from the analysis of blood flow in the 3D model of aortic dissection. In this study, we analyzed CT images obtained from three patients who had three different type of the aortic dissection, respectively. The fluid flow simulations were done by using COMSOL Multiphysics. The results from the computational simulation are able to explain the blood flow characteristics and are well accordance with the expectation from the patient’s condition and types of aortic dissection.
김기윤(G.Y. Kim),김보현(B.H. Kim),김윤년(Y.N. Kim),이용구(Y.G. Lee),허윤석(Y.S.Heo) 대한기계학회 2013 대한기계학회 춘추학술대회 Vol.2013 No.12
Aortic dissection is the most dangerousheart disease. It can cause aortic rupture in any time with treatment or without treatment. Thus patients must manage therisk factors. To control the factor like blood pressure, we need to set a threshold value for the safe zone for each patient.This important threshold can be obtained from analysis of blood flow. In this study, the clinical data was used to obtainthe 3D model of aortic dissection. The fluid flow simulation was done by using comsol multiphysics. We have preformed analysisin laminar fluid condition with inlet pressure. Velocity was analyzed along the 3d model. As we have expected, the velocitywas increased in the point of dissection was occurred. However, the increment of velocity was very large in the criticalarea.
간침생검으로 (肝針牲檢) 확진된 (確診) 각종 간암 (肝癌) 174예에서 SGOT / SGPT 비
백홍선,박성광,임창열,이용구,홍복희,안득수,손장신,박숙자 ( H S Baek,S K Park,C Y Yim,Y K Lee,B H Hong,D s Ahn,J S Son,S J Park ) 대한소화기학회 1981 대한소화기학회지 Vol.13 No.1
The SGOT/SGPT ratios were observed in 174 cases of various histologic types of hepatoma confirmed by needle biopsy, consisted of 164 cases of primary hepatoma and 10 cases of metastatic adenocarcinoma during the period of about 4 years from Jan. 1976 to Dec. 1979 in Jeon Bug National University Hospital and Jeon Ju Presbyterian Medical Center. The results were as follows: 1. Ratio of primary hepatoma to metastatic adenocarcinoma was lg.4: 1 and ratio of hepa- tocellular carcinoma to cholangiocarcinoma was 18. 6: I. Histologic types of primary hepatic carcinoma showed 153 cases(93.3%) of hepatocellular carcinoma, 8 cases(4.9%) of cholangiocarcinoma, 2 cases(I.2%) of hepatoblastoma and a case of mixed type. 2. Sex ratios(man to woman) were 4. 7: 1 in primary hepatoma group, 4. 1: 1 in metastatic adenocarcinoma group, 4. 5: 1 in hepatocellular carcinoma group and 7: 1 in cholangiocarcin- oma group. In hepatocellular carcinoma group, the most frequent decade was 6 th, 5 th, and 7 th decade in order(The mean age was 50. 7 years). In cholangiocarcinoma group, the age distribution was peak in 4th decade(Mean age was 56. 2 years) 4 Mean values of SGOT and SGPT were 98.4 and 50.6 Karmen unit respectively in primary hepatoma group. The SGOT/SGPT ratio was l. 93>0. 48 in primary hepatoma group. 5 In metastatic adenocarcinoma group, mean values of SGOT and SGPT were 48 and 49 Karmen unit respectively and the SGOT/SGPT ratio was 0. 97. 6, None of the metastatic adenocarcinoma patients had above 13 gm% of hemoglobin. But 9.2% of primary hepatocellular carcinoma patients showed over 15. 5 gm% of hemoglobin. 7 Alkaline phosphatases in primary hepatoma group and metastatic adenocarcinoma group were 3. 7 times(8. 66 Bessay-Lowry unit) and 4. 2 times(9. 87 Bessey-Lowry unit) as normal values respectively.