본태성혈소판증다증 (Essential Thrombocythemia) 1예

손장신,박숙자 대한병리학회 1981 Journal of Pathology and Translational Medicine Vol.15 No.1

한국인 종양의 통계적 관찰(호남지역을 중심으로)

손장신,정동규 대한병리학회 1981 Journal of Pathology and Translational Medicine Vol.15 No.2

Hymenochirus boettgeri의 궁둥신경 절단이 뒷다리뼈 발육에 미치는 영향에 대한 연구

손장신(Jang-Shin Sohn),김형태(Hyoung-Tae Kim) 대한체질인류학회 2007 해부·생물인류학 (Anat Biol Anthropol) Vol.20 No.4

본 연구는 Hymenochirus boettgeri의 궁둥신경 절단이 뒷다리 뼈 성장에 어떤 영향을 주는지 알아보고자 시도하여 다음과 같은 결과를 얻었다. 실험동물은 각각 Stage 63과 66 때 궁둥신경을 절단하여, 각각 6과 7주 후, 그리고 12와 13주 후에 alcian blue와 alizarine red로 염색하여 영상분석기로 넙다리뼈의 길이와 평면적, 정강뼈의 길이를 측정하였다. 첫째로, 단순한 피부절개는 뼈의 성장이나 발육에 영향을 주지 않으며, 둘째로 궁둥신경 절단은 넙다리뼈와 정강뼈의 길이성장에 영향을 주어 2~9%의 감소를 보여주었고, 셋째로, 궁둥신경 절단은 넙다리뼈의 단위평면적에 도 영향을 주었다. 넷째로, 신경절단된 넙다리뼈의 골화과정의 지연이 형태학적으로 관찰되었다. 이상의 결과는 다른 연구자들의 연구와 종합해 볼 때 궁둥신경의 절단은 넙다리뼈와 정강뼈의 성장에 직접적인 영향을 준다고 사료된다. 또한 이러한 다리뼈의 성장의 감소는 골화과정의 지연과 뼈성장과정의 임계시기의 상실에 의한 것이라 사료된다. The effect of peripheral nerve on limb growth and maturation has received little attention after the limb differentiation stage. This study investigated the effects of paralysis (loss of function) on growth of bones in the hind limb of Hymenochirus boettgeri. Complete denervation of the right sciatic nerve was performed at stages 63 and 66, animals were sacrificed after 6 and 7 (Groups I and Ⅱ) and 12 and 13 (Groups Ⅲ and Ⅳ) weeks. Denervation was assessed by degree of paralysis. Specimens were cleared and double stained with alcian blue and alizarin red for cartilage and bone. Length and area of right and left femurs and length of right and left tibia were measured by using an image analyzer program after photographing, and the ratio of right to left femur length and area was calculated. There were no gross morphological differences between the control and sham groups. In the experimental groups, the ratio of femur length was 93.71% and 95.70% in Group Ⅰ and Ⅱ, and 96.12% and 96.06% in Group Ⅲ and Ⅳ. The ratio of tibia length was 94.05% and 96.15% in Group Ⅰ and Ⅱ, and 98.12% and 98.22% in Group Ⅲ and Ⅳ. The ratio of femur area was 90.43% and 95.61% in Group Ⅰ and Ⅱ, and 96.08% and 95.73% in Group Ⅲ and Ⅳ. Comparison between control and experimental groups showed statistically significant (p<0.05). There was a histologically maturational delay in proximal end of denervated hind limb, comparing with opposite side. These results suggested that denervation of sciatic nerve affect directly the growth and maturation of hind limb bones in Hymenochirus boettgeri and loss of critical period of bony maturation after denervation.

세균뇨의 선별 검사법에 관한 연구

문대수,손장신,박영진,정용호 대한임상병리학회 1986 대한임상병리학회지 Vol.6 No.1

칸디다성 패혈증 (Candida Septicemia)2예

박숙자,손장신 대한임상검사정도관리학회 1980 臨床檢査와 精度管理 Vol.2 No.1

Colonic Adenocarcinoma Arising from Gastric Heterotopia: A Case Study

고형석,손장신,박신영,차은정 대한병리학회 2013 Journal of Pathology and Translational Medicine Vol.47 No.3

Heterotopic gastric mucosa occurs in all areas of the gastrointestinal tract including the nasopharynx, tongue, esophagus, small intestine, colon, and rectum. Gastric heterotopia of the large bowel is infrequent, and most cases have been reported in the rectum. Review of the literature has revealed only eight cases involving the colon proximal to the rectum. Little is known of the natural history of gastric heterotopias, except that. It usually presents with gastrointestinal bleeding, though other serious complications such as bowel perforation, intussusceptions, and fistula formation, are possible. Further, it is unclear whether heterotopic gastric mucosa progresses to malignancy. Herein, we describe a case of adenocarcinoma of the transverse colon arising from gastric heterotopia. To the best of our knowledge, this is the first report of adenocarcinoma arising from heterotopic gastric mucosa in the colon.

국균증 ll예

황호원,손장신,서재홍 대한병리학회 1985 Journal of Pathology and Translational Medicine Vol.19 No.3

IgG4-Related Disease with lymphadenopathy Presenting as a Cervical lymph node enlargement

최연석,김성민,손장신,황지용,장태수,조도연 고신대학교(의대) 고신대학교 의과대학 학술지 2017 고신대학교 의과대학 학술지 Vol.32 No.2

During the course of evaluation and management of neck masses, consideration for Immunoglobulin G4-related disease (IgG4-RD) should be given. IgG4-RD is relatively a new growing entity of immune-mediated origin, characterized by a mass-forming lesion, the infiltration of IgG4-positive plasma cells and occasionally elevated serum IgG4. The most common manifestations are parotid and lacrimal swelling, lymphadenopathy and autoimmune pancreatitis. A previously healthy 72-year-old man was referred to our clinic with a 2-month history of left cervical lymph node enlargement without systemic manifestations . A cervical lymph node biopsy was planned because of elevated serum IgG4 levels. Pathological findings showed prominent infiltration of IgG4-postive plasma cells in the lymph node. After steroid therapy, a computed tomography scan revealed a decrease in the cervical lymph node size. This case illustrates the importance of including IgG4-RD in the differential diagnosis of a cervical lymph node enlargement.

Clinicopathologic Review of the Intraductal Papilloma of Breast

윤대성,유미라,손장신,김금원,이정의,박해덕,최인석,최원준 한국유방암학회 2010 Journal of breast cancer Vol.13 No.1

Purpose: Intraductal papilloma of the breast (IDP) is the most common causes of nipple discharge and it is often a solitary, centrally located tumor that most commonly occurs in the fifth and sixth decades of life. There have been many conflicting reports on the malignant potential of IDP. Methods: From February 2003 to November 2008, we operated 161 patients who were diagnosed with IDP at Konyang University Hospital. A retrospective review of all the pathologic reports and the corresponding radiological reports was undertaken. Results: The mean age of the patients was 43.23 years (SD, ±10.1). Eighty-three (51.6%) had nipple discharge, 37 (44.6%) had bloody discharge and 46 (55.4%) had yellowish serous discharge. Twenty-four had a mass and 2 had both bloody discharge and a mass. Radiologic significant findings were shown on 20 mammography exams, 71 ductography exams and 157 breast ultrasound exams. Onehundred forty-four (89.4%) patients with IDP or papillomatosis had surrounding pathologic lesions in the operated specimen according to the final pathology, 107 (66.5%) had fibrocystic change, 26 (16.1%) had fibroadenoma, 30 (18.6%) had atypical ductal hyperplasia (ADH), 11 (6.8%) had carcinoma in situ and 4 (2.5%) had invasive ductal carcinoma. During the follow up, 7 patients (4.3%) developed recurrent IDP, 3 patients developed ADH and 5 patients developed carcinoma in situ (4 patients had ductal carcinoma in situ and 1 patient had lobular carcinoma in situ). Conclusion: Intraductal papilloma should be closely followed up due to its malignant potential and the surrounding breast tissue with IDP should be carefully evaluated due to the high rate of developing other precancerous lesions.

연구개에 발생한 근상피종 1예

배경희,안정현,손장신,이종빈 대한이비인후과학회 부산,울산,경남 지부회 2014 임상이비인후과 Vol.25 No.2

Myoepitheliomas consisting exclusively of myoepithelial cells, are very rare tumor that comprise 1% or less of salivary neoplasms and are generally benign. They occur, principally, in the parotid gland and infrequently in minor salivary glands. In its appearance and growth pattern, myoepithelioma resembles pleomorphic adenomas but is more aggressive thanpleomorphic adenoma. There are distinct histological and immunohistochemi calcharacteristics of the tumor which aid in the diagnosis. Treatment is the same as for pleomorphic adenoma and the surgical excision should include a margin of normal tissue. Myoepithelioma of the palate is uncommon and a case has not been reported in the Korean otorhinolarygologic literature. Herein, we report case of myoepitheliomaof the palate in a 53-year-old male who was treated by surgical excision with review of the literature.