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아토피성 피부염 동물모델에서 Black currant seed oil의 비장세포 cytokine 및 조직병리학적 변화에 미치는 영향
이예서 ( Ye Seo Lee ),박교현 ( Kyo Hyun Park ),김배환 ( Bae Hwan Kim ) 한국미용학회 2016 한국미용학회지 Vol.22 No.3
This study investigated the cytokine excretion of spleen cells and histopathological changes in atopic-like dermatitis model, and evaluated the anti-atopic effects of black currant seed oil. BALB/c mice (five-week old) were divided into four groups: N (normal group, nontreated), C (control group, induced atopic dermatitis), PC (positive control group, Tacrolimus ointment treatment for induced atopic dermatitis), and E (experiment group, Black currant seed oil treatment for induced atopic dermatitis, E). During the experiment, no significant changes were observed in feed intake, water, intake, body weight. The INF-γ levels of spleen cells in PC and E showed a significant increase compared to those of C, and. IL-4 levels in PC and E decreased significantly than those of C (p<0.05). In histological observation using H&E staining, the tissue thickness of the epidermis and the degree of inflammatory cell infiltration were improved in PC and E compared to C. The numbers of mast cells by toluidine blue staining were significantly decreased in PC and E than C (p<0.05). The results of this study indicated that black currant seed oil can improve the atopic dermatitis by regulating the Th1/Th2 cytokine ratio and histopathological mechanism.