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이수용,이태욱,Gyu Tae Park,Jae Ho Kim,이현채,Jung-Hwa Han,Aeseon Yoon,Dahye Yoon,Shukmann Kim,Soon Myung Jung,Jin Hee Choi,Min Ku Chon,Sang Hyun Lee,Ki Won Hwang,Jeongsu Kim,Yong Hyun Park,June Hong Kim,Kook J 대한심장학회 2021 Korean Circulation Journal Vol.51 No.3
Background and Objectives: Large clinical studies of sodium/glucose cotransporter 2 (SGLT2) inhibitors have shown a significant beneficial effect on heart failure-associated hospitalization and cardiovascular events. As SGLT2 is known to be absent in heart cells, improved cardiovascular outcomes are thought to be accounted for by the indirect effects of the drug. We sought to confirm whether such benefits were mediated through SGLT2 expressed in the heart using myocardial infarction (MI) model. Methods: Mice pre-treated with empagliflozin (EMPA), an SGLT2 inhibitor, showed a significantly reduced infarct size compared with the vehicle group three days post-MI. Interestingly, we confirmed SGLT2 localized in the infarct zone. The sequential changes of SGLT2 expression after MI were also evaluated. Results: One day after MI, SGLT2 transiently appeared in the ischemic areas in the vehicle group and increased until 72 hours. The appearance of SGLT2 was delayed and less in amount compared with the vehicle group. Additionally, there was a significant difference in metabolites, including glucose and amino acids in the 1H nuclear magnetic resonance analysis between groups. Conclusions: Our work demonstrates that SGLT2 is transiently expressed in heart tissue early after MI and EMPA may directly operate on SGLT2 to facilitate metabolic substrates shifts.
이수용,Lee, Sooyong 한국센서학회 2017 센서학회지 Vol.26 No.4
According to recent studies by scientists about how to search for food, homes and the mates, it is found that the gradient information plays a key role. From cells to insects and large animals, they mostly either have special sensing organism or use a strategy to measure the gradient. Use of a perturbation as an additional input is introduced for sensor signal processing in order to get the gradient information. Different from typical approach, which calculates the gradient from differentiation, the proposed processing is done by a form of integration, thus it is very robust to noise. Discrete time domain analyses are given for one, two and three input functions for the estimation of the gradients. The amplitude and the frequency of the perturbation are two important parameters for this approach. A quantitative index to measure the effects of the amplitude is developed based on the linear regression analysis. The frequency of the perturbation is to be selected high enough to finish one period of the perturbation before the property is changed significantly with respect to time. Another quantitative index is proposed for guiding the selection of the frequency.
이수용,전대근,이종석,김석준,조경자,오형호,박민효,박현수,장진대,Lee, Soo-Yong,Jeon, Dae-Geun,Lee, Jong-Seok,Kim, Sug-Jun,Cho, Kyung-Ja,Oh, Hyung-Ho,Park, Min-Hyo,Park, Hyun-Soo,Jang, Jin-Dae 대한근골격종양학회 1996 대한골관절종양학회지 Vol.2 No.1
From January 1994 to August 1995 we performed 270 cases of fine needle aspiration cytology for bone and soft tissue lesions. Among them 137 cases were diagnosed histologically. Sixty-seven cases were benign and 70 cases were malignant. We analysed these on the aspect of sensitivity, specifity, positive predictive value, negative predictive value of the cytologic examination. Malignant cases consisted of bone tumor 29 cases; soft tissue tumor 25 cases; and metastatic tumor 16 cases. The sensitivity and specifity of the aspiration cytology for malignant tumor were 67.8% and 97%, respectively. The positive and negative predictive value of aspiration cytology were 97.4% and 72.7%, respectively. Among them 40 cases were primary bony lesions; 14 benign lesions, 26 malignamt bone tumors. Sensitivity of aspiration cytology for these primary bony lesion was 90%(18/20) and its specifity was 100%(13/13). Three cases showed atypical cells in cytology but with biopsy we could find them as one benign and two malignancies. Two cases of manignancy showed negative result in cytology; one was parosteal sarcoma of proximal femur and the other was osteosarcoma of proximal tibia which was biopsied already at other hospital. Although the overall sensitivity and specifity for malignant bone and soft tissue tumors were relatively low and not so predictable, the fine needle aspiration cytology for primary bony lesion was useful in the differential diagnosis of benign or malignancy.
이수용,Lee, Soo-Yong 항공우주시스템공학회 2007 항공우주시스템공학회지 Vol.1 No.4
This paper presents critical buckling loads of laminated composites under cylindrical bending. In-plane displacements are assumed to vary exponentially through plate thickness. The accuracy of this theory is examined for symmetric/antisymmetric cross-ply, angle-ply and unsymmetric laminates under cylindrical bending. Analytical solutions are provided to investigate the effect of transverse shear deformation on critical buckling loads of the laminated plates, and the results are compared with those obtained from the first-order shear deformation plate theory and the classical laminated plate theory.
전이성골암에 의한 통증에 대한 Salmon Calcitonin($Miacalcic^{(R)}$) 비강분무의 효능 및 안정성
이수용,전대근,이종석,김석준,홍석일,최수용,장진대,Lee, Soo-Yong,Jeon, Dae-Geun,Lee, Jong-Seok,Kim, Sug-Jun,Hong, Seok-Il,Choi, Soo-Yong,Jang, Jin-Dae 대한근골격종양학회 1996 대한골관절종양학회지 Vol.2 No.1
Metastaic bone tumors are usually accompanied with severe pain. The treatment modalities for this pain are so variable that patients are sometimes afraid of using them. Salmon calcitonin has a function to increase beta-endorphines followed by increasing the blood level of prostaglandin and thromboxan A2, which results in analgesic effect. This drug also has been known to decrease bone resorption. There were a few reports that parenteral use of salmon calcitonin decrease the pain from metastatic bone tumor. We wanted to know the effectiveness and tolerability of nasal spray of salmon calcitonin in relieving bone pain with metastatic tumor. We analyzed the effectiveness in the aspects of pain, sleep, performance status, mobility, supplementary analgesic use. The biologic effect of salmon calcitonin was analysed with CBC, Ca/P, BUN/Cr, uric acid. Simple radiography, alkaline phosphatase, osteocalcin, pyrilink-K were used as parameters for bone change. Eighteen cases of metastatic bone tumors took nasal spray of salmon calcitonin($Miacalcic^{(R)}$, 200IU/day) for 4 weeks, to relieve bone pain. With Wilcoxon Matched-Pairs Signed Ranks Test, we could find pain decreased significantly at 3 week and mobility become improved at 4 week of salmon calcitonin use. Other parameters didn't show any significant changes. We think the analgesic effect is mainly due to effect not on the local bone lesion but on the central nervous system, and that increased dose of salmon calcitonin can induce earlier and stronger analgesic effect.