최근 5년간 피부질환의 통계적 고찰

방동식(Dong Sik Bang),조정구(Chung Koo Cho),이성락(Sung Nack Lee) 대한피부과학회 1983 大韓皮膚科學會誌 Vol.21 No.1

The incidence of skin diseases in the hospital practice cannot give a true picture of their prevalence in the population served. Nevertheless the hospital incidence figures usually offer the only available means of assessing prevalence, and therefore provide us with a potentially valuable source of information on the ecology of many skin disorders. (countinued..)

Vitamin A Acid 의 국소도보에 의한 좌창치료의 임상적 고찰

이성락,김성훈 대한피부과학회 1976 大韓皮膚科學會誌 Vol.14 No.4

In 1932, Harris, et al., reported that vitamin A had an anti-keratinizing effect on acne vulgaris, and in 1948, Straumfjord, somewhat over-enthusiastically reported that oral use of vitamin A also had a beneficial effect on acne. In spite of studies by Lynch and Cook (1947), and Andrew and Stokoe (1963), which questioned its effectiveness, the original enthusiasm for this regimen has not been completely dampened. Kligman (1969) reported that vitamin A acid (VAA), a metabolic end-product of vitamin A metabolism, produced a peeling effect and when applied topical was effective in tbe treatment of acne. The mechanism of action of VAA is incompletely understood, however, it is observed to cause, arnong other things, an increase in the speed of proliferation of the cells of the epidermis; dissolution of the intracellular lysosomes; increase in the rate of keratin formation and the conversion of hard keratin to soft keratin; and an increase in the secretion of the sebaceous glands. The effect of VAA in acne treatment is due to the increase in the secretion of the sebaceous glands which prevents the formation of comedones. It is believed that the increased spced of cell division, increased keratinization and softening of the keratin cause a weakening of the intercellular adhesion. These processes cause an acceleration of the flow of cells out of the sebaceoua glands which prevents the formation of comed.ones and forces existing comedones to the surface of the skin. For this study, thirty eight patients with acne vulgaris were selected from among the outpatients of Severance Hospital. They were divided into two groups. The first group was treated with application of vitamin A acid alone. The second group was treated concurrently with topical vitamin A acid and oral tetracycline.

전신성 홍반성 낭창의 임상 및 검사소견

이정복,최종수,이성락 대한피부과학회 1982 大韓皮膚科學會誌 Vol.20 No.5

Systemic lupus erythematosus is an autoimmune disease characterized by multisystem involvement and various laboratory findings. A retrospective study was made of the medical records of 59 patients with SLE at Severance hospital, Yonsei University College of Medicine, for the analysis of clinical and laboratory findings during the years 1970 through 198I. The results were compared with those of previous serial studies in Korea and western countries. The results obtained are as follows: 1. In 59 patients with SLE, 7 patients were men and 52 patients were women (M: F=l: 7.4). Their age at onset of the dsiease ranged mainly in the 3rd and 4th decades. 2. The major clinical manifestations were skin eruptions (81%), fever(73%), renal involvements(66%), pulrnonary(66%) and cardiac(61%) abnomalities. 3. The variety of skin and mucus membrane manifestations seen included butterfly rash of face(53%), maculopapular eruption (34%), purpura(22%), and mucosal ulcer (19%) in that order. 4. Mucosal ulcers and alopecia were correlated closely with exacerbations of disease activity. Patients with Raynauds phenomenon were not likely to have severe organ involvement. 5. Compared with Western series, renal manifestation, anemia and thrombocytopenia were more frequent, and lymphadenopathy, Raynauds phenomenon and alopecia were less frequent. 6. The ANA test showed a, high sensitivity(96%) and a high titer. Compared with the patients showing a speckled pattern(30%), those showing a homogenous pattern(60%) had more severe organ involvement and poorer prognosis. 7. The anti-nDNA antibody test had a high sensitivity(81%), and indicated. severe renal involvement and poorer prognosis. Also, the titer correlated well with disease activity. 8. The disease was associated with autoimmune hemolytic anemia, Buergers disease, thyroid diseases, myelofibrcsis and chilblain. 9. A bimodal rnortality pattern was seen with infection being the major cause of early death, and renal failure and cardiopulmonary abnormalities in late death.

최근 일반 건강인에 대한 매독 혈청검사 성적 : 1981년 1981

이정복,송경순,이해을,이성락 대한피부과학회 1982 大韓皮膚科學會誌 Vol.20 No.4

Serologic tests for syphilis including VDRLand FTA-ABS tests have been carried out in 2,753 VISA applicants for emigration, 8, 501 blood donors and 2, 588 pregnant women from January to December 1981. We have also been observing biologic false positive rate in 759 VDRL-reactive persons among those tested for STS in Severance Hospital in the year 1981, All the above subjects were twenty years old or over. The results are summarized as follows: 1. In 2, 753 VISA applicants, VDRL test showed postive in 42 applicants ( 1. 5 %). Of these 42 applicants, 37(1. 3%) had a rmotie FTA ABS test. 2. In 8,501 blood donors, the reactive rate for the VLRL test was 1.0%. 3. ln 2, 588 pregnent women, the VDRL test showed gositive in 20 women (0.8%). Of these 20 women, l8(0.7%) had a reactive FTA-ABS test. 4. The cuantitative test of VL'RL resulted in low titer below 1: 4 in 97. 6% of VDRL-reactive VISA applicants and in 85. 0% of VLRL-reactive pregnant women. 5. The overall biologic false positive rate was 8. 7/o in 759 VDRL-reactive persons amorg those tested for STS in Severance Hospital in time year l98l, using the FTA-ABS test as the standard. In particular, it was higher, namely 17. %, in 32 persons who were weakly reactive to the VDRL test. From the results it is clear that the prevalence of syphilis is gradually decreasing recently compared to the mid 1970's.

Subesepsis Allergica 1 예

박윤기,이성락,명기범 대한피부과학회 1979 大韓皮膚科學會誌 Vol.17 No.2

Subsepsis allergica's main characteristics are high intermittent fever, irregular recurring exanthemata of different types, neutrophil leukocytosis, increased sedimentation rate, negative culture, no demonstrable cause and good prognosis. This disease usually oecurs in children under age of fifteen. We had opportunity to observe a case in 30 year-old fernale presenting most of the above mentioned charactristics and presumably belonging to this disease entity. Other fever producing diseases were excluded by clinical featuree, serologic tests and skin biopsy. It was treated by antibiotics and salicylate without effect, but it responded to corticosteroid.

Gougerot - Blum 증후군을 동반한 급성 골수아세포성 (骨髓芽細胞性) 백혈병 1 예

김홍진,이성락,명기범 대한피부과학회 1977 大韓皮膚科學會誌 Vol.15 No.4

Gougerost-Blum syndrome is a rare disease and characterized by lichenoid papules in association with purpuric lesions. So far as we know there has been no report of, in literatures, Gougerot-Blum syndrome with leukemia. We experienced a case of typical Gougerrot_Blum syndrome with acute myeloblastic leukemia in a 30 year-old female patient. This patient complained of rashes on whole body for 2 months, and frequent epistaxis and gum bleeding for 20 days. The skin revealed miliary to rice sized rusty colored lichenoid papules on whole body especially on legs and arms. Histopathologically the skin showed the picture of Gougerot-Blum syndrome. On peripheral blood examination and bone marrow aspiration myeloblastic leukemia was confirmed. The patient was treated with 6-mercaptopurine, cytoxan and prednisolone with slight improvement of skin lesions, but no improvement of leukumia itself.

중부지방에서 발생한 Microsporum canis 의 감염증

김영근,이승헌,김주덕,이봉기,이성락,고창조 대한피부과학회 1980 大韓皮膚科學會誌 Vol.18 No.4

In 1957, human skin infection by M. canis were firstly reported in Kyungsang province in Korea. Later, in 1960 new cases were also reported in the other province, the Choongchung. However, M. canis infection has been reported only sporadically in Seoul city. This extremely low incidenc in this area may not represent true negative rate but reflect lack of the alertness of .M. canis infection. During the years 1978 and 1979, 15 out-patients were diagnosed as M canis infection of the skin at the Department of Dermatology of Severance Hoapital, Yonsei University. These 15 patients were found to belong to six different families residing in the central Korea and never resided outside of that area, The Kyungki province. Majority of the cases(11/15) were clinically diagnosed as tinea corporis, as Kerion celsi and 4 cases were tinea capitis. Among them, combined infection by tinea capitis and tinea corporis were confirmed in two patients. Although the ages of the pateints were widely distributed from 2 to 36 years, children under age 10 were the major population among them. Five domestic cats from 5 families were examined and confirmed to be infected by M. cams.

Dermatophyte Test Medium ( DTM ) 의 임상적 이용에 관한 연구

김홍식,조정구,진홍상,이성락 대한피부과학회 1976 大韓皮膚科學會誌 Vol.14 No.3

Diagnosis of dermatophytosis is relatively easy with the typical clinical feature but sometimes we need more studies such as direct microscopy and culture to confirm the diseaee. The direct microscopic test is simple and ra.pid, but the result is often complexing, and the culture needs rnuch experience, skill, and deep knowledge in mycology. In 1959, Taplin et al. devised Dermatophyte Test Medium(DTM) which contains phcnol red as a color indicator for the simplified diagnosis of dermatophytosis. Result can be evaluated by noting the change of the color indicator of the medium. from yellow to red without detailed knowledge of colony morphology. So the non-mycologist can recognize well by color change of the medium. Moreover DTM is superior to Sabouraud medium in eliminating bacterial contamination, allowing a higher recovery rate and early recongnizing, since the color change of the medium begin to appear with the growth of fungus. The cultures were done on DTM and Sabouraud medium in 105 cases of the suspected dermatophytosis. In DTM, dermatophytes were cultured in 53 cases(M. canis 1, T. mentagrophytes 24, T. rubrum 28) and the color changes were observed in all of them. The others were 29 cases of Candida spp. 5 cases of saprophytes, and only one case of bacterial contaminatiion was observed. Compared with DTM, the dermatophytes were cultured in 36 cases and bacterial contamination were 16 csses in Sabouraud medium. The colors of DTM of 53 cases of dermatophytes were changed to red between the second to fourteenth day after culture. In 8 cases of Candida spp. among 29, 3 cases of saprophytes among 5, thc color change of DTM begin to appear after tenth day of culture. So DTM is very useful for the diagnosis of dermatophytosis by unsk;illed personnel under most environmental condition with only redimentary knowledges of colonial morphology to distinguish contaminant fungi and bacteria from dermatophytes.