Ether 및 Halothane 전신마취(全身麻醉)가 가토폐(家兎肺) 및 간조직(肝組織)의 단백량(蛋白量)에 미치는 영향(影響)

이석강,신현국,조중환,이기석,Lee, Suck-Kang,Shin, Hyun-Cook,Cho, Joong-Hwan,Lee, Ki-Suk 대한생리학회 1971 대한생리학회지 Vol.5 No.1

In an attempt to observe possible effects of ether and halothane anesthesia on the protein contents of the lung and liver of rabbits, the animal was subjected to the moderato anesthesia with either ether or halothane by non-rebreathing system for one hour, and the protein content of the lung and liver was measured by the method of Lowry et at. using Folin-phenol reagent. The comparison was made with the protein content from the normal rabbits, and the following results were obtained. l) The protein contents of the lung and liver of the normal rabbit were $45.0{\sim}11.5\;mg/gm$ wet wt. and $100.4{\sim}15.1\;mg/gm$ wet wt. respectively. 2) In the ether or halothane anesthesized group, the protein contents of the lung were $57.2{\sim}13.3\;and\;60.3{\sim}7.2$ respectively. 3) In the anesthesia groups with ether and halothane, the protein contents of the liver were $103.4{\sim}10.0\;and\;90.1{\sim}13.0$ respectively. 4) No significant difference in the protein contents of the lung and liver was observed after ether or halothane anesthesia comparing with the normal.

건강인(健康人) 및 직업적(職業的) 매혈(賣血)로 인(因)한 실혈성(失血性) 빈혈자(貧血者)의 적혈구(赤血球) 취약성(脆弱性)에 관(關)하여

이석강(Lee, Suck-Kang),유광수(Yoo, Kwang-Soo),김형규(Kim, Hyung-Kyu),곽동수(Kwak, Dong-Soo) 대한생리학회 1971 대한생리학회지 Vol.5 No.2

The osmotic and mechanical red cell fragility of the professional blood donors, who were found to be anemic as the result of frequent and repeated blood loss the past 5-6 years, were compared with that of the normal person while incubating the blood at 4-6℃ for 28 days. The fragility was expressed as % hemolysis occured during the incubation, and the following results were obtained: 1. The osmotic fragility in the normal persons (i.e, ; control group) progressively increased as the incubation became longer, and % hemolysis in 0.42% NaCl solution at 0, 10, 15, 21 and 28 incubation day was 31.90, 50.20, 41.68, 43.50 and 55.40 respectively. The mechanical fragility. in the normal red cells ranged between the minimum of 0.00% to the maximum of 5.80% both in 0.90 and 0.66% of NaCl solutions. 2. The hemolysis curve obtained in the red cell osmotic fragility from three cases of the anemic persons (i.e,; experimental group) showed a significant left side shift comparing with the normal in general which indicates that the fragility was more increased in the experimental group. The mechanical fragility in the experimental group ranged between the minimum 0.00% to the maximum 19.00% both in 0.90 and 0.66% of NaCl solutions. 3. The red cells of the chronic anemic person due to the frequent blood loss as the professional blood donor exhibit significantly marked increase both in osmotic and mechanical fragility comparing with the normal, and the tendency was more prominent as the incubation period became longer.

Betamethasone이 일측폐장절제 가토폐장의 압력-용적곡선에 미치는 영향

이영만,이석강,Lee, Young-Man,Lee, Suck-Kang 대한생리학회 1983 대한생리학회지 Vol.17 No.1

steroid가 폐절제에 의한 대상성증식기의 폐장의 압력-용적곡선에 어떤 영양을 미칠 것인가를 알아보기 위해 실시한 본 실험의 결과를 요약하면 폐절제군은 대조군에 비해 폐용압률이 증가하였고 폐절제후 반대측폐장의 무게는 대조군에 비해 폐절제군이 유의하게 증가하였고 폐절제후 betamethasone을 투여한 군에 있어서는 대조군에 비해서는 증가하였으나 폐절제군보다는 적게 증가하였다. 또한 이러한 결과들은 betamethasone에 의해 폐포표면활성물질의 분비가 증가하였거나 혹은 betamethasone이 폐장실질의 결합조직의 단백대사에 영향을 미쳐 elastic recoil force가 감소하여 생긴 결과라고 생각된다. In order to clarify the effect of steroid on the pulmonary pressure-volume curve in the pneumonectomized rabbit, the right side pneumonectomy was performed under general anesthesia with pentobarbital sodium and the remaining lung was excised on the fifth day after surgery. The intrapulmonic pressure in the excised left lung was measured at 20, 25, and 30 ml lung volume during inflation and deflation period. In the steroid treated group, the intrapulmonic pressure at 20, 25, and 30 ml lung volume during inflation was significantly decreased compared with intrapulmonic pressure of the control group. But in the pneumonectomy group the decreasing tendency of the pressure was observed. During deflation, the intrapulmonic pressure at 25 ml and 20 ml was not significantly different from the control group in pneumonectomy and steroid treated pneumonectomy group. And the lung weight was measured in each experimental group and also the lung weightbody weight ratio(L/B) was calculated. The lung weight was significantly increased in both pneumonectomy and steroid treated pneumonectomy group. Calculated L/B was increased significantly in both group. Above results suggest that steroid increases the secretion of pulmonary surfactant or affects the catabolic effect on protein metabolism of connective tissue in lung parenchyma.

일측폐장절제가 잔류폐, 간 및 신장의 대상성 증식과 혈청전기영동상에 미치는 영향

이영만,이석강,주영은,Lee, Young-Man,Lee, Suck-Kang,Choo, Young-Eun 대한생리학회 1983 대한생리학회지 Vol.17 No.2

In order to clarify the effect of the unilateral pneumonectomy on the compensatory growth of the residual lung, liver and kidney, and serum electrophoresis pattern, right lung pneumonectomy was performed on rabbits under general anesthesia with pentobarbital sodium. On the fifth day after the surgery, the weight of the residual lung, liver and bilateral kidneys was measured and organ weight-body weight ratio was calculated. And in an attempt to know whether the cells in the liver and the kidney were proliferated by unilateral pneumonectomy, DNA content was determined. The quantity(g/100 ml) of serum protein was determined also and serum electrophoresis was performed on cellulose acetate membrane. The results obtained are summarized as following. The weight of the residual lung and lung weight-body weight ratio was significantly increased respectively. The weight of the liver and organ weight-body weight ratio were not changed but the DNA content of the liver and kidney tissue increased significantly, illustrating that unilateral pneumonectomy caused cellular hyperplasia in the liver and in the kidney as well as in the residual lung. The quantity(g/100 ml) of serum protein was significantly increased and in the analysis of the electrophoregram, there was significant difference between the normal and pneumonectomy group. Taken together, these results indicate that unilateral pneumonectomy caused the compensatory hyperplasia of the liver, the kidney and the residual lung as well as the change of electro-phoretic pattern. And it also suggests that a humoral factor, which proliferates the cells in the residual lung, the liver and the kidney, existed in the pneumonectomized rabbits.

경막외강(硬膜外腔)에 주입(注入)한 생리식염수(生理食鹽水)가 뇌척수액압(腦脊髓液壓)에 미치는 영향(影響)

전재규,이석강,주영은,Jeon, Jae-Kyu,Lee, Suck-Kang,Choo, Young-Eun 대한생리학회 1977 대한생리학회지 Vol.11 No.1

Many cases have been reported that a post spinal headache can be relieved immediately by an epidural injection of saline; and autologous blood also has recently been used successfully instead of saline. The changes of the cerebrospinal fluid pressure in 40 cases were observed in the present study in support of the concept; that a continuous leakage in association with hypovolemia and hypotension of the cerebrospinal fluid is the primary cause of a post spinal headache. Subarachnoid pressure increased immediately with saline injection into the lumber epidural space. A spinal needle was inserted into the subarachnoid space at the level of $L2{\sim}3$ and opening pressure of the cerebrospinal fluid was read. An epidural Tuohy needle was insertad at the$L3{\sim}4$ and 25m1 of saline was injected into the epidural space and the cerebrospinal fluid pressure was read in the sitting position. $\underline{Sitting\;Position:}$ Mean pressure after injection $555{\pm}(110.9)mm\;H_2O$, Pressure rise rise (%) 51.3%, Mean opening pressure $366{\pm}(52.2)mm\;H_{2}O$, $\underline{Lateral\;position:}$ Mean pressure after injection $308{\pm}(70.8)mm\;H_{2}O$, Pressure(%) 86.7%, Mean opening pressure $165{\pm}(42.6)mm\;H_{2}O$. These pressure changes responded almost simultaneously as saline was injected. This pressure rise of 51.3% in the sitting position and 86.7% in the lateral position are clinically very significant. Therefore, it is most possible that the immediate relieve of post, spinal headache by injection of fluid into the epidural space is simultaneous with the increase of the cerebrospinal fluid pressure.

석고고정 후 회복기 골격근의 당원대사

이용주(Yong-Joo Lee),김종연(Jong-Yeon Kim),안종철(Jong-Chul Ahn),이석강(Suck-Kang Lee) 대한정형외과학회 1995 대한정형외과학회지 Vol.30 No.3

출혈성 쇼크시 전신혈역학 변동이 간혈류 및 간세포 기능에 미치는 영향

이상일(Sang Ill Lee),이상춘(Sang Choon Lee),이석강(Suck Kang Lee),김홍진(Hong Jin Kim),서보양(Bo Yang Suh),권굉보(Koing Bo Kwun) 대한외과학회 1990 Annals of Surgical Treatment and Research Vol.38 No.4

관절고정이 골격근의 당대사 및 인슐린 수용체에 미치는 영향

이동철(Dong Chul Lee),류재만(Jae Man Ryoo),인주철(Joo Chul Ihn),김종연(Jong Yeon Kim),이석강(Suck Kang Lee) 대한정형외과학회 1992 대한정형외과학회지 Vol.27 No.4

체위 변화에 수반되는 순환 및 호흡반응

채의업(Chae, E-Up),이석강(Lee, Suck-Kang),배성호(Bae, Sung-Ho) 대한생리학회 1973 대한생리학회지 Vol.7 No.1

An attempt was made to study circulatory and respiratory responses to the passive tilt. Anesthetized dogs were tilted from horizontal to upright (+90˚) and head down (-90˚) position. The arterial blood pressure was decreased in the upright position and was decreased slightly in the head down position comparing to that in the horizontal position. Cardiac index also decreased in the both upright and head down positions. The total systemic vascular resistance was slightly increased in the upright position and was markedly increased in the head down position. The mean pulmonary arterial pressure was significantly decreased in the both upright and head down positions. The total pulmonary vascular resistance was decreased in the both upright and head down positions. Oxygen consumption was slightly decreased in the upright position, whereas it was slightly increased in the head down position. The A-V O₂ difference (vol. %) was slightly increased in the upright position and increased in the head down position. From the above results, process of the circulatory compensation to the gravity in the Passive tilting test was discussed. Neuronal cardiovascular regulation to the gravity and tile adaptation of capacitance vessles to hydrostatic stress and oxygen consumption concerning anoxic endurance of the brain were also discussed.

폐세척으로 유발된 호흡부전에서의 고빈도 Jet 환기법의 효과

이관호(Kwan Ho Lee),박시화(Si Hwa Park),노진우(Jin Woo Rho),김태년(Tae Nyeun Kim),정진홍(Jin Hong Chung),이현우(Hyun Woo Lee),이석강(Suck Kang Lee) 대한내과학회 1992 대한내과학회지 Vol.43 No.6

N/A Background: To identify the efficiency on gas exchange and pulmonary pathologic changes of high frequency jet ventilation (HFJV) compared with conventional mechanical ventilation (CMV) in saline-lavaged rabbits. Methods: Twenty New Zealand white rabbits (2.7-3.1 kg) were studied under intravenous anesthesia. Following tracheostomy, a surfactant-depletion lung- injury model was produced by normal saline lavage. During the next 2 hours, rabbits were ventilated with CMV or HFJV. Arterial blood gas was measured every 30 minutes. After completion of 2 hours ventilation, the animals were sacrified and the lungs were fixed for microscopy and the degree of hyaline membrane formation was compared in each ventilation. Results: Arterial oxygenation was more efficient with HFJU (395±124mmHg, 379±127mmHg, 412±115mmHg and 421±119mmHg, at 30 minutes, 60 minutes, 90 minutes and 120 minutes) than with CMV (79±38mmHg, 81±48mmHg, 107±103mmHg and 119±123mmHg; p < 0.001), A sustained inflation resulted in immediate and sustained increase in PaO2 with HFJV (from 81±25mmHg to 357±109mmHg), but no significant increases with CMU (from 80±22mmHg to 100±68mmHg). Arterial oxygenation was more efficient with HF3V (395±124, 379±127, 412±115 and 421±119mmHg, at 30, 60, 90 and 120 minutes) than with CMV (79±38, 81±48, 107±103, 119±123mmHg; p<0.0001). Hyaline membranes were slightly more developed with CMU, but not significant compared with HFJV. Death resulted from pneumothorax or a progressive metabolic acidosis with CMV, but all the rabbits with HFJV survived until the planned termination of the protocol. Conclusions: HFJV produced more efficient gas exchange, when combined with a sustained inflation in surfactant-depletion lung-injury model by saline lavage, however, did not improve pulmonary pathology.