강황(薑黃)이 고환절제술 및 testosterone으로 유발된 rat의 전립선비대증에 미치는 영향

이상헌,안영민,안세영,김영옥,이병철,Lee, Sang-Hun,Ahn, Young-Min,Ahn, Se-Young,Kim, Young-Ock,Lee, Byung-Cheol 대한한방내과학회 2009 大韓韓方內科學會誌 Vol.30 No.2

Objectives : Benign prostatic hyperplasia (BPH) is one of the most common diseases among elderly men. Though medicines such as 5${\alpha}$-reductase inhibitor (finasteride) have recently been developed for treating BPH, their adverse effects and low efficacy should not be overlooked. Curcuma longa has a long history of use in traditional medicines of Asian countries. Many reports conclude the component curcumin in Curcuma lonfa, has the potential to treat various diseases including prostate cancer. In this study, we investigated the therapeutic effects and action mechanism of Curcuma longa with a BPH rat model. Methods : Sprague-Dawley rats were used with subcutaneous injection of testosterone after castration, which were histologically similar to human BPH. A total of 30 rats were equally divided into five groups: Group 1 served as control (sham-operated group): Group 2 was the model group: Group 3 and Group 4 animals were administered Curcuma longa at dose levels of 0.5g/kg and 1.0g/kg: Group 5 served as a positive control group and was treated with finasteride at a dose of 1 mg/kg. The drugs were administered orally once a day for 30 days consecutively. After 31 days, the prostates were removed, and analyzed for their prostatic weight and histological examination. Results : The oral Curcuma longa ingestion group showed statistically significant decreases in their prostatic weights compared with the BPH-induced group and the oral finasteride ingestion group (p<0.05). Curcuma longa is also very safe in liver and kidney up to a dose of lg/kg. Injected testosterone histologically led to prostatic hyperplasia in rats, but oral Curcuma longa ingestion decreased this change. Conclusions : These results suggest that Curcuma longa has a definite inhibitory effect on BPH and might be an alternative medicine for treatment and prevention of human BPH.

부자(附子)가 6-propyl-2-thiouracil(PTU)로 유발된 rat의 갑상선 기능저하증에 미치는 영향

이상헌,이병철,안영민,두호경,안세영,Lee, Sang-Hun,Lee, Byung-Cheol,Ahn, Young-Min,Doo, Ho-Kyung,Ahn, Se-Young 대한한방내과학회 2007 大韓韓方內科學會誌 Vol.28 No.2

Objective : Although hypothyroidism is a common disease in the endocrinology system, it is reported that there are a lot of difficulties in treating it effectively. Aconiti Ra얕 traditionally has been used in treatment of coldness, fatigue, and bradycardia. In this study, we investigated the therapeutic effects of Aconiti Radix on hypothyroidism rat model induced by 6-propyl-2-thiouracil (PTU). Methods : Two-month-old rats were used with administration of PTU which induced hypothyroidism in the rats. After 2 weeks, Aconiti Radix and thyroxine were administered, respectively. The body weights were measured every week. After 4 weeks, the blood samples of all rats were taken from their hearts. They were analyzed biochemically and $T_4$ (thyroid hormone) & TSH (thyroid stimulating hormone) was measured by ELISA kits. Results : In comparison with normals, controls showed hypothyroidism with significantly low $T_4$ and high TSH the statistics. In Aconiti Radix administration groups significantly increased $T_4$ was observed in the statistics and its effects were dose-dependent. There was no difference statistically in TSH of Aconiti Radix treatment groups from controls, nor were statistical differences observed significantly in biochemical labs and weight of each group. Conclusions : These findings suggest that Aconiti Radix protects thyroid cells and makes thyroid cells produce thyroid hormones. It is also very safe in the view of liver, kidney function, and other metabolism. It may be a useful agent for treating hypothyroidism.

근대건축의 개념에 대한 비판적 소고 -기능(술)주의, 형식주의, 예술주의와 전망-

이상헌,Lee, Sang-Hun 한국건축역사학회 1999 건축역사연구 Vol.8 No.1

Modernism in architecture is a very complex and contradictory phenomena. So much so that it has been defined in various ways throughout the history, depending on one's position in the cultural and historical circumstances. It is thus necessary to map out the various concepts of modernism and their relationships in order to have a more comprehensive understanding of modern architecture. This paper attempts to define the various positions as functionalism, formalism and artistic avant-gardism, and to trace their history from the early twentieth century to the present. The change of the concept of modernism from functionalism to artistic avant-gardism seems a logical process in the history of western modem culture. The tendency of contemporary architecture to be more abstract and self referential artistic practice reflects the fragmentation of modern culture and the separation of art and technology. The validity of this position, of course, depends on how one evaluates the role of modern art in the situation of modern culture. It could be viewed either negatively or positively. However, this position is problematic in that it disregards the fundamental differences between architecture and other arts and distanced architecture farther from its material base. Given this historical perspective on the concept of modernism, modernism in Korea should not viewed simply identical to the western modernism, nor should western modernism be imported uncritically. The characteristics of her modernization and their differences from the west should be considered, along with the different status and role of architecture in korean modern society.

투시도적 표상에서 공간의 투사로 -2차원 그림의 3차원 투사를 활용하는 현대건축의 경향에 대한 연구-

이상헌,Lee, Sang-Hun 한국건축역사학회 2006 건축역사연구 Vol.15 No.3

Many contemporary architectural avant gardes tend to use painting as a medium to create architecture which goes beyond the rationalized spatial conception of modem architecture represented by perspectivism. They produce non perspective drawings to represent spatial Ideas, and expand it through poetic imagination to create an unexpected architectural form and space. This paper attempts to analyze the historical origin and background of dominance of drawing in the production of architecture. It was with the invention of perspective that architectural representation became important tool for architectural production. Thereafter, drawing was considered prior to actual building and architecture was considered a three dimensional realization of two dimensional drawing. Modernist avant gardes such as Cubism shattered the rationalized pictorial space of perspective and found a new pictorial space. They tried to extend it to three dimensional space through parallel projection largely based on the Hildebrand's theory of pure visibility. However, due to the ambiguity of the position of the viewing subject, their attempts could not succeed in creating a new architecture. The new architectural avant garde of the 70's rediscovered the early 20th century avant gardes in their attempt to create a new architecture which can register the fragmented spatial condition of contemporary society, and used painting as a medium to create architecture. Their difference from the early avant gardes was that they used poetic imagination rather than parallel projection in the process of projecting three dimensional space and form from the painting. However, their architecture cannot escape the scopic field of perspectivism in that they rely on the picture plane and the distance between object and viewing subject. Therefore, I conclude that in order to create architecture which goes beyond the rationalized space of modern architecture, it is necessary to resort to other tradition of modern architecture than visual one.

한국 근대건축사 서술의 문제와 과제

이상헌,Lee, Sang-Hun 한국건축역사학회 2015 건축역사연구 Vol.24 No.2

The tasks of writing history is to reconstruct the past in order to understand the present condition and to envision the future. Modern architectural histories in the west have assumed this role, from Winckelmann to Giedion. Likewise, history of Korean modern architecture has to serve this purpose. However, existing histories of Korean modern architecture simply list up stylistic changes from western eclectic architecture to modernism without any historical narratives explaining the transition from Korean traditional architecture to modern architecture. History of Korean modern architecture has simply been understood as a unilateral process of transplantation of western architecture into Korea. This paper points out two major problems underlying this kind of historiography of Korean modern architecture. The one is formalistic approach which sees history of modern architecture mainly as a process of formal and stylistic changes. The other is humanistic approach which sees modern architects as agents of history. This paper argues that this kind of history writings has limitations since modernity of Korean architecture is fundamentally different from that of the west. and that specific tasks that Korean modern architectural history has to address are then two folds;(re)connecting the past architectural tradition to the present and forming self-identity of Korean architecture.

사장석(斜長石)을 포함(包含)한 복수투영(複數投影)에 있어서의 행렬식(行列式) 이용(利用)에 관(關)한 연구(硏究)

이상헌,Lee, Sang Hun 대한자원환경지질학회 1984 자원환경지질 Vol.17 No.4

Projection method has been used in the phase equilibria study. The projection is made through the saturated phase on the smaller chemical system from larger system. This decreases the number of phases which are included in the larger chemical system. In multiple projection containing plagioclase as a projection phase, there is a difference in matrix calculation when plagioclase is treated as a single composite component and separately as an albite and anorthite. The matrix calculation is considered to be more usable and easier in multiple projection. The value of the A component in the AFM system, which is the smaller system projected from the larger one, is effected and varies according to the change in the An content in plagioclase that is examined as an example.

전통의 현대적 계승을 위한 한국 전통건축의 이론화에 대한 비판적 고찰

이상헌,Lee, Sang-Hun 한국건축역사학회 2015 건축역사연구 Vol.24 No.6

The purpose of this study is to critically investigate the ways in which scholars and architects in Korea have theorised the tradition in Korean architecture from the early 20th century to the present. After opening the door to foreign powers, the most important issue to be resolved in Korea architecture has been the modernization of the traditional architecture. The successful modernization of Korean traditional architecture depends on successful theorization of the tradition. However, many attempts to theorise the uniqueness of tradition in Korean architecture had not been instrumental to the modernization of Korean traditional architecture. The reason why they were not successful lies in the lack of philosophical and methodological reflection upon how to approach the tradition. They were either trapped in ambiguous essentialism without systematic methods and theories, or simply inventing the tradition from the vantage point of the present. This paper argues that in order to theorise the tradition, one need to translate the tradition into contemporary architectural vocabularies. What is important in translating the tradition is not to directly apply contemporary concepts and perceptual frame of architecture to traditional architecture but to find the gaps and differences between the two. This will open hermeneutic spaces to translate the tradition into useful principles and vocabularies of comtemporary architecture.

말레이시아 화인거리의 형성과정과 도시주거에 관한 연구 -말레이시아 말라카와 싱가포르를 중심으로-

이상헌,윤인석,Lee, Sang-Hun,Yoon, In-Suk 한국건축역사학회 1998 건축역사연구 Vol.7 No.4

The formation of Chinese Town in Malacca of Malaysia and Singapore would explain that Chinese gradually played an important role of commerce and urban service according to the Western European advance to southeast Asia and the construction of colonial cities from the 16th century to 19th and massed residence in many cites of southeast Asia. Chinese was usually separated from the Western European by western colonial policy and city planning. Common architectural characteristics in Chinese towns of Malaysia can refer to the transmission of the Chinese architectural material, the combination of dwelling and commerce in a house and the space organization centered on a court or an air well in the narrow and long site, lying adjacent to street etc. The Chinese dwellings in Malaysia rooted with Chinese settlement in southeast Asia. The Chinese dwellings was not always a shop on 1th floor and a dwelling on 2nd floor before the 19th century. But as Chinese immigration and commercial activity progressed in earnest in the early of 19th century, the row house of Chinese for dwelling was autonomously changed to two functional shophouse for dwelling and commerce. Chinese row house can refer to the use of Malay regional material, change of symmetrical Chinese traditional housing type by the narrow and long site and the tendency of the eclectic elevation of Western and China. Another architectural characteristics of the shophouse is an appearance of the continuous verandah with a cover regulated by Stamford Raffles in Singapore. This regulation was applied to architecture in Chinese Town as Stamford Raffles constructed Singapore. It was spread to South China reversely and became the regulation of streetscape for the modern city. Shophouse of Chinese towns in Southeast Asia and south China can be understood by context of Chinese immigration, colonialism, housing type of commerce and dwelling and the Western European city planning.

다문화가정 구성원 대상 교육프로그램 중재에 대한 체계적 고찰

이상헌,박경민,손순영,Lee, sang hun,Park, Kyung Min,Shon, Soonyoung 한국디지털정책학회 2021 디지털융복합연구 Vol.19 No.4

본 연구는 다문화가정 구성원을 대상으로 한 교육프로그램의 효과를 확인하는 체계적고찰 연구이다. 연구 방법은 국내 데이터베이스인 KISS, RISS, NDSL, DBia, nanet을 사용하여 출판된 문헌을 2020년 12월 1일부터 2021년 1월 7일까지 검색 후 총 21편의 연구를 분석하여 연구자 3인이 코드화한 후 정리하였다. 다문화가정을 대상으로 한 교육프로그램 중재의 특성은 자녀 대상 연구가 12편 부모 대상 연구가 8편 부모와 자녀를 모두 포함한 연구가 1편이었다. 중재프로그램의 속성에서 대다수의 연구가 건강, 반응적 돌봄, 조기교육을 포함하고 있었지만 영양과 안전 영역을 적용한 연구는 없는 것으로 나타났으며 다문화가정 구성원 모두를 대상으로 한 연구도 없는 것으로 나타났다. 본 연구를 통해 다문화가정 구성원 대상 교육프로그램 개발시 교육 요구도를 파악하고 이론적 기틀을 토대로 다문화가정이 겪는 문제를 포괄 할 수 있는 교육 프로그램 개발과 효과검증이 필요함을 알 수 있었다. This study was a systematic review that aimed to assess the effectiveness of educational programs for members of multicultural families. Therefore, 21 studies from domestic databases - RISS, KISS, NDSL, DBia, and nanet - were analyzed and the data were compiled and encoded by three researchers. Regarding the characteristics of the educational programs for multicultural families, 12 programs were developed for children, eight, for parents, and one, for both parents and children. While most intervention programs included topics on health, responsive care, and early education, none included topics on nutrition and safe space or targeted all members of multicultural families. This study identified the need for developing educational programs for all members of multicultural families and for developing and evaluating programs that can address, on a theoretical basis, the problems encountered by multicultural families.

만푸레도 타푸리의 이데올로기 비평과 건축의 실천에 대한 사상의 연구

이상헌,Lee, Sang-Hun 한국건축역사학회 2003 건축역사연구 Vol.12 No.2

Manfredo Tafuri's Ideological criticism in architecture has opened a new horizon to interpreting architecture in modern capitalist architecture for it views architecture not just as a style or formal invention, but in terms of socio-economical process. It offered a comprehensive understanding of a chaotic situation of contemporary architecture and historical meaning modern architectural movements in relation with capitalistic development. However, it has been criticized as architectural pessimism which does not allow any possibility for progressive architectural practice. It was also criticized of epistemological problem of how one could be outside ideology without assuming true consciousness against false consciousness of ideology. Tafuri solves this problem by assuming Althusserian activist concept of knowledge and suggest the concept of labor of writing history of critical historians, instead of a design for utopian society, as a possible critical architectural practice. However, I argue that ultimately ideological criticism does not deny architectural practice itself, nor researches on formal characteristics of architecture. The problem lies rather in the architectural Intellectuals' attachment to the traditional concept of architect as a form giver to the society. By rejecting this myth and broadening the concept of architectural practice from design to production, we can find that Ideological problem is not architectural pessimism, but rather it opens up a new way of approaching to the problem of architectural practice in modern capitalist society.