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RISS 인기검색어
- 검색키워드
- 저자 : 이상섭 ( Ok Hee Kim (검색결과 5 건)
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Nocardia SP . 에 의한 Δ4 - 3 - Ketosteroid 류의 산화
김옥희,이상섭 ( Ok Hee Kim,Sang Sup Lee ) 생화학분자생물학회 1974 BMB Reports Vol.7 No.1
Rationalizing of conformational or structural modification effect on 9α-hydroxylation of 17-ketosteroids which have Δ⁴-3-keto-system was attempted. When 6-methylandrost-4-ene-3,17-dione was incubated with Nocardia opaca, the rate of 9 a-hydroxylation was much slower than that of androst-4-ene-3,17-dione. In contrast, 9 a-hydroxylation of 6α-methylandrost-4-ene-3, 17-dione was faster than that of 6 ~-isomer. In addition to these two compounds, 19-norandrost-4-ene3,17-dione and 6,19-oxidoandrost-4-ene-3,17-dione were also compared with androst-4-ene-3,17-dione, and it was found that the rate of 9α-hydroxylation and B-ring rupturing of androst-4-ene-3,17-dione was fastest among tested steroids.
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Nocardia Sp.에 의한 ${\Delta}^4$-3-Ketosteroid 류의 산화
김옥희,이상섭,Kim, Ok-Hee,Lee, Sang-Sup 생화학분자생물학회 1974 한국생화학회지 Vol.7 No.1
Steroid의 핵구조(ring structure)가 $9{\alpha}$-hydroxylation에 미치는 영향을 검토하기 위하여 $6{\beta}$-methylandrost-4-ene-3, 17-dione, $6{\alpha}$-methylandrost-4-ene-3, 17-dione, 19-norandrost-4-ene-3, 17-dione, androst-4-ene-3, 17-dione과 6, 19-oxidoandrost-4-ene-3, 17-dione 등 ${\Delta}^4$-keto-system을 갖고 있는 steroid를 Nocardia opaca 배양액중에 첨가하여 주고 $9{\alpha}$-hydroxylation 되는 과정을 살폈다. ${\Delta}^4$-keto-system에 $6{\beta}$-methyl group이 존재하면 현저히 hydroxylation의 속도가 느린 것을 발견하였다. Rationalizing of conformational or structural modification effect on $9{\alpha}$-hydroxylation of 17-ketosteroids which have ${\Delta}^4$-3-keto-system was attempted. When $6{\beta}$-methylandrost-4-ene-3, 17-dione was incubated with Nocardia opaca. the rate of $9{\alpha}$-hydroxylation was much slower than that of androst-4-ene-3, 17-dione. In contrast, $9{\alpha}$-hydroxylation of $6{\alpha}$-methylandrost-4-ene-3, 17-dione was faster than that of $6{\beta}$-isomer. In addition to these two compounds, 19-norandrost-4-ene-3, 17-dione and 6.19-oxidoandrost-4-ene-3, 17-dione were also compared with androst-4-ene-3, 17-dione, and it was found that the rate of $9{\alpha}$-hydroxylation and B-ring rupturing of androst-4-ene-3, 17-dione was fastest among tested steroids.
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생강성분 6-Paradol의 세포 독성 및 병리학적 연구
김옥희,유은숙,정인경,이상섭,Kim, Ok-Hee,Yoo, Eun-Sook,Jung, In-Kyung,Lee, Sang-Sup 한국환경성돌연변이발암원학회 1998 한국환경성돌연변이·발암원학회지 Vol.18 No.1
It is previously reported that 6-paradol can induce prolonged analgesia in experimental animals. In order to investigate the mutagenicity of 6-paradol, Ames Samonella/microsome plate assay was carried out with Salmonella typhimurium strains, TA 98, TA 100, TA 1535 and TA 1538, 6-Paradol was nonmutagenic in Salmonella typhimurium with and without rat liver microsomal activation. The rec assay with Bacillus substilis strains H 17 $rec^+$ and M 45 $rec^+$ was carried out ot test 6-paradol and other compounds (1-3 mg/disc) for DNA damaging activity, 6-Paradol was also nonmutagenic in DNA damaging activity. The relative size of the inhibition zone for 6-paradol was smaller than that of capsaicin. We have also determined the pathological effects of this compound on the various tissues of rats after administrating(i.p.) with increasing doses of 4, 8, 12, 16 mg/kg at 2 hour intervals and found no significant changes in terms of histology.
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유은숙(Eun Sook Yoo),김옥희(Ok Hee Kim),손여원(Yeo Won Son),정인경(In Kyung Jung),이상섭(Sang Sup Lee) 대한약학회 1999 약학회지 Vol.43 No.1
To investigate analgesic mechanism of capsaicin and its analogues (capsaicinoids), adenosine release was measured by high performance liquid chromatography from rat spinal cord synaptosomes. Exposure of synaptosomes to K+ and morphine Produced a dose dependent release of adenosine in the presence of Ca++. Capsaicin (0.1, 1, 10mcM), and its analogues; NE-19550 (1, 10, 100mcM), DMNE (1, 10, 100mcM) and KR 25018 (0.1, 1, 10mcM) produced a concentration dependent release of adenosine in the presence of Ca++. Nifedifine, L-type voltage sensitive calcium channel blocker, inhibited K+ (6, 12mM)- and morphine (10mcM)-evoked release of adenosine partially. Capsazepine, a novel capsacin selective antagonist, blocked only capsaicin and capsaicinoids induced release of adenosine. Therefore, it is suggested that the adenosine release by capsaicin and capsaicinoids having antinociceptive effects involves activation of capsaicin specific receptor and capsaicin sensitive Ca++ channel.
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흰쥐 척수에서 지속성 진통물질 6-파라돌에 의한 아데노신의 유리 증가
유은숙(Eun Sook Yoo),김옥희(Ok Hee Kim),이상섭(Sang Sup Lee) 대한약학회 2000 약학회지 Vol.44 No.6
We previously demonstrated that 6-paradol, a compound structurally related to capsaicin, showed to produce prolonged analgesia in experimental animals. The effects of 6-paradol on the release of adenosine were investigated in the rat spinal cord synaptosomes by high performance liquid chromatography. In the presence of Ca++ adenosine was released from synaptosomes of rat spinal cord by 6-paradol and capsaicin in a dose dependent manner. Nifedifine, L-type voltage sensitive calcium channel blocker, was found to be ineffective in releasing adenosine by 10mcM 6-paradol. After exposure to 10mcM capsazepine, a novel capsaicin selective antagonist, the level of adenosine evoked by 10mcM 6-paradol was decreased by 75%, and that evoked by 10mcM capsaicin was blocked completely. These results suggest that the analgesic effect of 6-paradol might be mediated by the vanilloid (capsaicin) sensitive pathway, or the direct binding to the vanilloid receptor.
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