신생랫드에 투여된 capsaicin 유사체의 신경독성 연구

유은숙 제주대학교 생명과학연구소 2000 제주생명과학연구 Vol.3 No.-

This study examined the neurotoxic effects of neonatal administration of capsaicin and its analogues (capsaicinoids) on nociceptive threshold and the distributions of substance P (SP) in the dorsal horn of the spinal cord during the course of development in rats. Capsaicin (50 mg/kg), NE -19550 (200 mg/kg) reduced the density of spinal substance P- like immunoreactivity ( SPLI) in the dorsal horn, particularly in substantia gelatinosa at 3 weeks of age, and this reduction of immunoreactivity lasted for 10 weeks after the birth. In contrast, neonatal administration of DMNE (200 mg/kg) did not reduce the density of SP at 3, 7 and 10 weeks of age. Likely, neonatal administration of capsaicin, and NE-19550 increased the chemical nociceptive threshold by ophthalmic instillation of capsaicin (0.01 %), which was correlated with depletion of SP in the dorsal horn of the spinal cord.

Esterase 저해제를 생성하는 Streptomyces속 균주DMC-498의 종내세포융합에 의한 균주개량

유은숙,최응칠,김병각 서울대학교 1989 藥學論文集 Vol.14 No.1

Apoptosis: 조절 그리고 독성에의 관련성

유은숙 한국신약개발연구조합 1996 신약뉴스 Vol.4 No.1

원예활동이 여고생의 우울증에 미치는 영향

유은숙,노명래,이영현 인간식물환경학회 2002 인간식물환경학회지 Vol.5 No.2

유소아 개심술 환아에서 대동맥 캐뉼러의 이상위치에 의한 요골·대퇴동맥압간 차이의 발생

유은숙,이영석,박원선,한동우,방서욱,남상범,곽영란,한상건 대한마취과학회 1998 Korean Journal of Anesthesiology Vol.35 No.6

Background : Appropriate placement of aortic and venous cannulas is important to ensure effective systemic perfusion. The malposition of the aortic cannula may promote preferential flow down the aorta or induce flow to aortic arch vessels causing pressure gradient between mean radial arterial pressure (RAP) and femoral arterial pressure (FAP). In this study we compared mean radial to femoral artery pressure gradient before and immediately after aortic cannulation and during cardiopulmonary bypass (CPB). Methods : Ninety two pediatric patients undergoing open heart surgery were examined. After induction of anesthesia RAP and FAP were measured. The pressure gradient was measured before and after aortic cannulation, 15, 30 and 60 minutes after aortic cross clamping (ACC). When the pressure gradient of more than 10 mmHg developed, the surgeon was recommended to manipulate position of the aortic cannula. If the pressure gradient returned to pre-CPB level after manipulation, the pressure gradient was considered to develop due to aortic cannula. The age, presence of cyanosis, adjustment of shape of aortic cannula tip before cannulation and side of radial artery cannulation as factors developing pressure gradient were examined. Results : Fifteen patients (16.3%) developed pressure gradient due to position of aortic cannula. Two patients (2.2%) developed immediately after aortic cannulation and fourteen patients (15.2%) during CPB. There was no statistically significant factor developing pressure gradient except non-cyanotic disease. Conclusions : The pediatric patient could develop pressure gradient due to malposition of aortic cannula frequently during CPB. Therefore, the simultaneous monitoring of RAP and FAP may be beneficial for managing CPB in pediatric cardiac surgery. (Korean J Anesthesiol 1998; 35: 1124∼1128)

관상동맥 우회술및 판막대치술환자에서 체외순환 전·후의 대퇴·요골동맥압간의 차이의 변화 비교

유은숙,방서욱,홍용우,곽영란,임현경,한승연,장정화 대한마취과학회 1997 Korean Journal of Anesthesiology Vol.32 No.2

Background : It has been known that pressure gradient(PG) between systolic radial arterial pressure(RAP) and systolic aortic pressure(AP) is often altered after cardiopulmonary bypass(CPB). In this study, we compared radial to femoral arterial pressure(FAP) difference between valve replacement(VR) group(n=189) and coronary artery bypass graft (CABG) group(n=90). Methods : With IRB approval, anesthesia management followed the standard method for cardiac surgery. Heart rate, RAP, FAP, cardiac index(CI), forearm skin temperature, hematocirt and systemic vascular resistance index(SVRI) were recorded at before-CPB, after-CPB and after sternal closure. Results : In CABG group, there was no change of PG between RAP and FAP before and after CPB. In VR group, systolic RAP was similar with FAP before CPB but the radial-femoral arterial pressure gradient was reversed with statistical significance after bypass. Compare with CAGB group, change of pressure gradient after CPB cousiderded statistical significant in valve replacement group. CI was increased and SVRI was decreased with statistical significance. Conclusion : In our study, patients in VR group who demonstrated high CI and low SVRI showed reversal of PG upon cessation of CPB. Reversal of PG at post-CPB probably partially depends on the degree of systemic vasodilation upon discontinuation of CPB. (Korean J Anesthesiol 1997; 32: 260∼266)

고혈압 환자에서 기관내삽관시 심혈관계 반응에 대한 Remifentanil과 Alfentanil의 영향 비교

유은숙 대한마취통증의학회 2008 Anesthesia and pain medicine Vol.3 No.2

Background: Laryngoscopy and endotracheal intubation often provoke an undesirable increase in blood pressure and heart rate. This response may be exaggerated in patients with essential hypertension. We compared the effect of administration of remifentanil and alfentanil on the hemodynamic responses to endotracheal intubation in patients with essential hypertension. Methods: Forty patients with essential hypertension were allocated into two groups. The remifentanil group received 0.5μ g/kg remifentanil followed by an infusion of 0.25μg/kg/min remifentanil. The alfentanil group received 10μg/kg alfentanil intravenously. Anesthesia was induced with thiopental and vecuronium, and was maintained with 2 vol% sevoflurane with 100% oxygen. Laryngoscopy and tracheal intubation were performed 3 min after vecuronium administration. Arterial blood pressure and heart rate were measured in patients after arrival at the operating room and before and after intubation. Results: The systolic and mean blood pressure after intubation showed significantly higher values in the alfentanil group of patients than in the remifentanil group of patients. There was no significant difference in blood pressure measured at baseline and after intubation in the remifentanil group of patients, but blood pressure showed significantly higher values after intubation in the alfentanil group of patients. Heart rate showed significantly higher values after intubation than at baseline in each group of patients. Conclusions: These results show that the administration of 0.5μ g/kg remifentanil followed by an infusion of 0.25μg/kg/min remifentanil attenuated the pressor response to endotracheal intubation more significantly than the administration of 10μg/kg alfentanil in patients with essential hypertension.

경식도 심초음파(Transesophageal Echocardiography, TEE)를 이용한 심근운동장애의 조기 발견이 관상동맥 우회로술에 미치는 영향

유은숙,홍용우,곽영란,임현교,방서욱,윤동명 대한마취과학회 1995 Korean Journal of Anesthesiology Vol.29 No.3

Background; Regional wall motion abnormalities(RWMA) detected by intraoperative transesophageal echocardiography(TEE) are thought to be sensitive indicators of myocardial ischemia. The present study was undertaken to elucidate management of RWMA with an immediate regraft in the area of RWMA or conventional drug therapy. Method; Twenty-six patients undergoing coronary artery bypass graft surgery were examined with TEE. After induction of anesthesia, TEE probe was inserted into esophagus and connected to Echo system. LV short axis views at the mid-papillary muscle level were viewed and recorded. TEE showed postbypass RWMA in 6 cases and one patient who did not have the TEE developed postbypass RWMA viewed by the epicardial echocardiography. Regraft was performed at the area of RWMA in 3 patients. The remainder was treated with intraaortic balloon pump(IABP) and/or inotropics. Results; The patients with regraft showed an immediate improvement of the new RWMAs. The patients treated with IABP and/or inotropics had improvement of hemodynamics but did not show any improvement of the RWMAs. All seven patients developed hypotension and ST segment changes. All patients with the conventional treatment and two out of 3 regraft patients developed the postoperative myocardial infarctions. Conclusion; In conclusion this study demonstrated that patients experiencing persistent RWMA would be more likely to have myocardial infarction than those having only transient changes and that TEE would be an excellent tool for early detection of myocardial ischemia and might improve treatment of ischemic events. (Korean J Anesthesiol 1995; 29: 351~357)

Studies on the Analgesic Mechanism of Capsaicin - capsaicin-evoked adenosine release and metabolism of capsaicin

유은숙,박영호,이상섭 한국응용약물학회 1994 학술대회 Vol.1994 No.1

대학생의 외모관리 기대가치와 뷰티관리행동 간의 관계에서 외모자신감의 조절효과

유은숙,나윤영 한국의류산업학회 2023 한국의류산업학회지 Vol.25 No.3

This study aims to investigate the moderating effect of appearance confidence in the relationship between theexpected value of appearance management and beauty management behavior of college students. For data collection, 300questionnaires were distributed among the students of a 4-year university in Gwangju, Republic of Korea from April 12to 22, 2022; 273 copies were collected, and 259 copies were used as the final sample. SPSS 21.0 was used to analyze thecollected data, and the results were as follows. First, the expected value of appearance management had a positive (+)effect on beauty management behavior. Second, the expected value of appearance management had a statistically sig-nificant positive (+) effect on beauty management behavior. Taken together, the results of the study show that the higherthe level of social internalization, play and sympathy values, and appearance confidence of the expected value of appear-ance management, the higher the college students’ beauty management behavior. Taken together, the results of the studyshow that the higher the level of social internalization, play conformity value, and appearance confidence of the expectedvalue of appearance management, the higher the college students' beauty management behavior. This was confirmed toact as a reinforcing mechanism.