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SEREX; discovery of tumor antigens
이상률,Lee, Sang-Yull Korean Society of Life Science 2007 생명과학회지 Vol.17 No.6
종양항원의 동정과 발견은 암 백신 및 진단개발에 매우 중요하다. 암환자의 혈청에서 종양 항원를 동정하는 SEREX가 개발되어왔다. SEREX에서 동정된 종양항원은 진단의 분자 지표 뿐 만 아니라 항암 백신 개발에 응용되고 있다. 따라서 SEREX는 종양항원 동정에 사용되어지는 매우 강력한 방법이다. 항암 백신의 개발은 동정된 종양항원이 체 또는 T cell에 기초하여 작동하는지 해명하는 것이 중요한 요소이다. 이 논문은 강력한 종양항원의 동정 방법인 SEREX 의 응용에 관하여 고찰 할 것이다. The identification of tumor antigens is essential for the development of anticancer therapeutic vaccines and clinical diagnosis of cancer. SEREX (serological analysis of recombinant cDNA expression library)has been used to identify such tumor antigens by screening sera of cancer patients with cDNA ex-pression libraries. SEREX-defined antigens provide markers for the diagnosis of cancers. SEREX is also a powerful method for the development of anticancer therapeutics. The development of anticancer vaccines requires that tumor antigens can elicit antigen-specific antibodies or T lymphocytes. This re-view provides information on the application of SEREX for discovery of tumor antigens.
이승표(Seung Pyo Lee),이나연(Nah Yon Lee),차채영(Chae Yeong Cha),이인하(In Ha Lee),이상률(Sang Roul Lee),김원익(Won Ik Kim),김태우(Tae Woo Kim) 대한기계학회 2012 대한기계학회 춘추학술대회 Vol.2012 No.11
The automotive wheel bearing is one of important components in vehicle to translate the power and bear the weight. Bearing life is affected by many parameters such as bearing geometry, bearing specification, vehicle specification, loading conditions, lubrication conditions, material properties, and so on. In this paper, the optimization of the bearing life was performed using design of experiments. A factorial design was applied to carry out the bearing life calculation proposed by ISO 281:2007 and to investigate the design variables effects influencing on bearing life. The determination of the significance of effects in an experiment was made through the analysis of variance. The results showed that operating temperature and contamination affected the bearing life significantly.
Modified View Factor를 이용한 인공위성 분자오염 역류확률 예측법
이진원(Jin-Won Lee),이재달(Jae-Dal Lee),이민영(Min-young Yi),한동인(Dong-In Han),이창호(Chang-ho Lee),이상률(S. R. Lee) 한국항공우주학회 2005 韓國航空宇宙學會誌 Vol.33 No.4
인공위성의 outgassing 분자에 대한 역류오염 해석에는 BGK 또는 DSMC 등의 방법이 사용되어 왔으나, 이들은 해석이 복잡하고 시간이 오래 걸리는 등의 비효율성이 문제이다. 본 논문에서는 분자들의 충돌간 평균자유행로가 위성체의 크기에 비해 매우 길고, 동시에 위성체의 속도가 분자들의 열속도보다 매우 크다는 점을 이용하여, 간단한 근사모델을 도입함으로써 일반적인 view factor 법과 비슷한 편리성과 간편성을 가지면서 DSMC 법과 정확하게 일치하는 결과를 주는 modified view factor 법을 개발, 제안한다. Satellite contamination from back-scattered molecules has long been analyzed using the BGK theory or the DSMC technique which are rather inefficient in that they are complicated or take a long time in the analysis. This study presents a new technique of estimating the back-scattering contamination, which is very simple and easy to use like the view factor method and also very accurate. This method, called the modified view factor method, is equivalent to the DSMC in so far as the molecular thermal velocity is much smaller than the satellite velocity and the mean free path much longer than the satellite.
이상률(Sang Ryull Lee) 대한통증학회 1997 The Korean Journal of Pain Vol.10 No.2
Stellate ganglion block has been used to treat diseases such as peripheral vascular disease, sympathetic dystrophy, and various pain syndromes involving the head or arm. Raynaud's disease is a syndrome manifested by attacks of pallor, cyanosis, numbness and pain of the digits in response to cold or emotional change. report one case who was given Stellate ganglion block using 18G teflon Catheter(4.5 cm in length) for Raynaud's disease. Continuous stellate ganglion block is more convinient to inpatient than repeated needle punctures and may reduce major complications and more useful to patient who needs continuous sympathetic block about one week duration,
Ice plant (Mesembryanthemum crystallinum) 추출물의 생리 활성
이상률(Sang Yull Lee),최현덕(Hyeun Deok Choi),유선녕(Sun Nyoung Yu),김상헌(Sang Hun Kim),박슬기(Seul Ki Park),안순철(Soon Cheol Ahn) 한국생명과학회 2015 생명과학회지 Vol.25 No.6
본 연구는 ice plant (Mesembryanthemum crystallinum)의 생리활성을 분석하여 기능성 식품으로서의 가능성을 조사하였다. Ice plant는 아프리카와 서유럽, 북미, 남미 그리고 호주에서 서식하는 다육식물로 항당뇨, 항산화, 지질 대사 활성에 효능이 있다고 알려져 있다. Ice plant를 methanol (MCM), ethanol (MCE), 열수(MCHW), 열수추출 후 methanol (MCHM)로 추출하여, mushroom tyrosinase, pancreatic lipase, DPPH free radical 소거 활성, NO 생성, α-glucosidase에 대한 저해 활성을 측정 하였다. MCM, MCE, MCHW, MCHM 추출물의 추출 수율은 0.37%, 0.33%, 0.5%, 0.07%로 나타났다. MCHW 추출물은 DPPH free radical 소거능에 높은 효과를 보였고, MCM, MCE 추출물은 lipase 저해 활성, α-glucosidase 저해 활성, NO 생성 저해활성을 보였다. 그러나 mushroom tyrosinase 저해 활성은 모든 추출물에서 매우 낮았다. 이러한 결과를 통해 ice plant는 항산화 물질로서 비만, 당뇨, 염증 치료용 기능성 식품으로서의 가능성이 매우 높음을 확인할 수 있었다. This study analyzed the physiological quality of Mesembryanthemum crystallinum (ice plant) extract. M. crystallinum is a succulent plant found in Africa, southern Europe, North America, South America, and Australia. It has known antidiabetic, antioxidant, and activation of lipid metabolism effects. Extracts from M. crystallinum were prepared with methanol (MCM), ethanol (MCE), hot water (MCHW), and methanol after hot water (MCHM) extractions. The yields of MCM, MCE, MCHW, and MCHM were 0.37, 0.33, 0.50, and 0.07%, respectively. To determine the biological activities of the extracts, mushroom tyrosinase, pancreatic lipase, 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging, nitric oxide (NO) production, and α-glucosidase assays were conducted. The DPPH radical scavenging activity of the MCHW extract was 62.9% at a concentration of 400 μg/ml, which was the highest of all the extracts. The MCM extract showed the highest inhibition activity of α-glucosidase and NO production (56.6 and 57.2%, respectively). The pancreatic lipase inhibition of the MCE extract was similar to that of the MCM extract, with significant inhibition of 90%. The mushroom tyrosinase inhibition of all the extracts was very low (approximately 30%). These results suggest that extracts from M. crystallinum have antioxidant, anti-inflammatory, antiobesity, and antidiabetic activities. Thus, it may have potential as a functional food product and therapeutic potential as an antidiabetic or antiobesity agent.