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Recent Progress in Lab-on-a-Chip Technology and Its Potential Application to Clinical Diagnoses
이내윤 대한배뇨장애요실금학회 2013 International Neurourology Journal Vol.17 No.1
We present the construction of the lab-on-a-chip (LOC) system, a state-of-the-art technology that uses polymer materials (i.e.,poly[dimethylsiloxane]) for the miniaturization of conventional laboratory apparatuses, and show the potential use of these microfluidic devices in clinical applications. In particular, we introduce the independent unit components of the LOC system and demonstrate how each component can be functionally integrated into one monolithic system for the realization of a LOC system. In specific, we demonstrate microscale polymerase chain reaction with the use of a single heater, a microscale sample injection device with a disposable plastic syringe and a strategy for device assembly under environmentally mild conditions assisted by surface modification techniques. In this way, we endeavor to construct a totally integrated, disposable microfluidic system operated by a single mode, the pressure, which can be applied on-site with enhanced device portability and disposability and with simple and rapid operation for medical and clinical diagnoses, potentially extending its application to urodynamic studies in molecular level.
宋南玉,李內允 우석대학교 의과대학 1968 우석의대잡지 Vol.5 No.1
Clinical studies on tension headache which is one of the utmost importances, not only in the practice of psychiatry but also in general practice, were carried out through clinical observation and with the analysis of Rorschach test results. This analysis was performed according to the recently developed scoring system of Robert R. Holt and Joan Havel which is based on the content analysis of the responses. The headache group was comprised from 78 cases of anxiety neuroses and 24 cases of neurotic depressions whose chief complaint was dominantly headache, and the control group, which was named as non-headache group, comprised from 36 cases of anxiety neuroses and 25 cases of neurotic depressions whose chief complaint was other than headache. The results of this study are as follows. 1. Female group shows higher incidence of headache(71.62% of all anxiety neurotics and 50.00% of all neurotic depressives) than male group(62.50% of all anxiety neurotics and 47.06% of all neurotic depressives). 2. Of the age distribution in the neurotic depressives the female are younger than the male. 3. The order of incidence of location of headache is whole(48.04%), occipital(22.55%), frontal(8.82%), temporal(6.86%), and others(11.76%). 4. The content analysis of the Rorschach responses reveals that the productions of aggressive drives are more dominant in the group of headache(9.95% in anxiety neurotics and 9.32% in neurotic depressives) than of non-headache(8.58 % in anxiety neurotics and 6.32 % in neurotic depressives) and the productions of libidinal drives conversly are more dominant in the non-headache group(6.22% in anxiety neurotics and 4.74% in neurotic depressives) than in the headache group(5.04 % in anxiety neurotics and 2.73 % in neurotic depressives). 5. More detailed analysis of the productions of aggressive drives reveals that sadistic slant and castration fear are more dominant in the group of headache(sadistic slant. 2.28% in anxiety neurotics and 1.82% in neurotic depressives. castration fear, 4.24% in anxiety neurotics and 4.78% in neurotic depressives) than of non-headache(sadistic slant... 2.24% in anxiety neurotics and 0.45% in neurotic depressives. castration fear, 3.11 % in anxiety neurotics and 2.94 % in neurotic depressives). 6. Detailed analysis of the productions of libidinal drives reveals that oral and exhibitionistic-voyeuristic drives are more dominant in the non-headache group(oral, 2.98% in anxiety neurotics and 1.58% in neurotic depressives. exhibitionistic-voyeuristic. 0.62% in anxiety neurotics and 0.23% in neurotic depressives) than in the headache group(oral, 1.61% in anxiety neurotics and 1.14% in neurotic depressives. exhibitioraistic-voyeuristic, 0.13% in anxiety neurotics and 0.00% in neurotic depressives). 7. Concerning the types of experience balance introversive types are more dominant than extratensive types in the group of headache(introversive types, 57.69% of anxiety neurotics and 70.83% of neurotic depressives and extratensive types, 299.49% of anxiety neurotics and 20.82 % of neurotic depressives) comparing with that of non-headache group(introversive types, 52.78% of anxiety neurotics and 32.00% of neurotic depressives and extratensive types, 27.78% of anxiety neurotics and 44.00% of neurotic depressives). 8. In the headache group, especially in the anxiety neurotics, it is revealed that the more introversive they are the more productions of aggressive drives. 9. From these results it is suggested that the unresolved aggressive drives play the most dominant role in producing neurotic tension headache.