하부위장관 기능장애 치료의 한의학적 접근방법에 관한 연구

이건업,원진희,문구,문석재,류수택,Lee, Gun-Up,Won, Jin-Hee,Moon, Gu,Moon, Seok-Jae,Ryu, Su-Taek 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.1

Irritable Bowel Syndrome(IBS) is the most common disease in the western male, and it is founded in $70{\sim}80%$ patient who has Gastrointestinal trouble. It is characterized by the formation of disorders of Gastrointestinal tract, for example, constipation, diarrhea, abdominal pain& discomfort, stool urgency, and so on. The etiology of IBS is uncertain, but the majority of patients has emotional problems. The aims of this study are to investigate and summarize the current trends of treatment for IBS so as to suggest the effective and available way to treat this disease. In Oriental Medicine, the IBS is recognized as Stagnation of the Iiver-qi(肝氣鬱結), Incoordination between the liver and the stomach(肝胃不和). So the point of treatment of IBS is Invigorating the spleen and relieving the depression of Iiver-qi(疏肝健脾), Regulating the function of the liver and the flow of qi(調肝理氣), Regulating the stomach and lowering the adverse flow(和胃降逆), and the treatment can be approached in several ways through herb drugs, acupuncture. Some of the herb drugs have substances which promote gastric and small intestinal emptying. Acupuncture and moxibustion therapies stimulate the meridian points of LR(足厥陰肝經), ST(足陽明胃經), LI(手陽明腸經), SI(手太陽小腸經) and is reported to be effective for releafing syndromes. Anal therapy, attachment of herb drug to umbilicus are annunced as the effective treatments. So, this study of the approach and application of these treatments on IBS would be necessary.

肛腸療法에 의한 小靑龍湯의 알레르기 反應抑制效果

李建業,文錫哉,文九,元秦喜 한국전통의학연구소 1998 한국전통의학지 Vol.8 No.2

Anal Therapy is another way of taking medicine. It is a traditional pathway but not available in common situation. Nevertheless, It has many benifect and usefulness, it has not treated so much. As there are many kinds of Anal therapy, this study use retention type. Sochungyongtang (SCYT) has been known to be the most effective prescription largely applied to bronchial asthma, whooping cough, pneumonia, pleurisy, nephritis and arthritis and so forth. In this study, the author investigated the effect of an aqueous extract of SCYT by Anal therapy (Retention Enema) in immediate type allergic reaction. The following results were obtained 1. Retention Enema of SCYT showed a marked inhibition rate in systemic immediate-type allergic reaction with a dose of 1000 mg/kg 1 hr before intraperitoneal injection of compound 48/80. 2. SCYT significantly reduced serum histamine contents induced by compound 48/80. SCYT (1000 mg/kg) also inhibited to 64.11±19.86% (P<0.01) local immediate-type allergic reaction activated by anti-dinitrophenyl (DNP) IgE. 3. In addition, SCYT dose-dependently inhibited the histamine release from the peritoneal mast cells by compound 48/80 or anti-DNP IgE. These results provide evidence that anal therapy (Retention enema) of SCYT may be beneficial in the treatment of systemic and local immediate-type allergic reaction.

八珍抗癌丹의 인간 前骨髓性 白血病 세포 사멸 효과

이건업(Gun Up Lee),문석재(Seok Jae Moon),문구(Goo Moon),원진희(Jin Hee Won),김동웅(Dong Woung Kim),김형균(Hyung Kuen Kim),문영호(Young Ho Moon),이종범(Jong Bum Lee),윤준철(Jun Chul Yoon),김홍준(Hong Joon Kim) 한의병리학회 2002 동의생리병리학회지 Vol.16 No.3

白花蛇舌草 메탄올 抽出物에 의한 HL-60 세포 고사과정의 caspases 活性變化 硏究

김일주,이건업,소홍섭,박래길,원진희,문구,문석재 한국전통의학연구소 2000 한국전통의학지 Vol.10 No.1

The effects of aqueous and methanol extracts of hedyotis diffusa(a traditional medicine for cancer treatment in oriental medicine) on the activations of caspase proteases were investigated in the hedyotis diffusa's extract-induced cell death of human lymphoid origin leukemia cell lines, HL-60. The death of HL-60 cells was markedly induced by the addition of only methanol extract of hedyotis diffusa in a dose dependent manner. The activation of caspase-2 was occurred very early upon treatment of cells with the methanol extract of hedyotis diffusa and appeared to precede the activation of caspase-3. The activations of caspase-3, -6, -8 and -9 were also induced. Time course analysis indicated that the cleavage of caspase-8 and -9 precedes those of caspase-3 and -6. In addition, cytochrome c release was detected very early time. Taken together, these results suggest that the hedyotis diffusa's methanol extract-induced cell death of HL-60 may be involved by the activations of several caspase cascade such as caspase-3, -8 , and -9 via cytochrome c release.

팔물탕합화적환(八珍湯合化積丸)의 항종양(抗腫瘍) 효과(效果)에 관(關)한 연구(硏究)

송봉길,이건업,원진희,문구,문석재,소홍섭,박래길,김성진,Song, Bong-Gil,Lee, Gun-Up,Won, Jin-Hee,Moon, Gu,Moon, Seok-Jae,So, Hong-Sup,Park, Rea-Gil,Kim, Sung-Jin 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.1

Objectives : The effects of cotreatment of adriamycin and ethanol extract of herb (Palgin-tang hab Hwajuck-hwan a traditional medicine for cancer treatment in oriental medicine) on the induction of apoptotic cell death were investigated in human liver origin cell lines, Chang. Methods : Chang(ATCC) liver cells were cultured in RPMI-1640(Gibco SRL Co, Gaithersburg, MD) badge including 10% fetal bovine serum. Chang liver cells were treated with various concentrations(from 10 to $0.16{\mu}l$) of adriamycin and herb extract(from 500 to $31.25{\mu}l$) After 48h later, the cells were tested for viability by Crystal violet staining assay. Adriamycin and Herb extract induced ladder pattern of DNA fragmentation in Chang cells. Genomic DNA was isolated and separated on 1.5% agarose gels. The DNA was stained with ethidium bromide and visualized under UV light. Results : The death of Chang cells was synergistically induced by the cotreatment of adriamycin and ethanol extract of herb. In addition, the cotreatment-induced cell death of Chang cells was mediated by apoptotic death signal processes. The phosphotransferase activity of JNK1 remained in a basal level in Chang cells which was treated individually with the adriamycin and ethanol extract of herb. However, it was markedly increased in Chang cells which was cotreated with adriamycin and ethanol extract of herb. In addition, the expression of Fas and FasL was markedly induced by the cotreatment of adriamycin and herb extract. For a while, the expression of Sax was a eminently increased by the ethanol extract of herb. However, Scl2 expression was not affected by the individual or cotreatment of adriamycin and herb extract. Conclusions : our results suggest that the cotreatment of adriamycin aM ethanol extract of herb induces synergistic apoptotis of human liver origin Chang cells via the upregulation of JNK, Fas, FasL and Bax.

東醫寶鑑에 인용된 黃帝內經素問․靈樞에 대한 考察

전영세,원진희,이건업 한국전통의학연구소 2000 한국전통의학지 Vol.10 No.2

We studied the phrases and the sentences of Dong-Eui Bo Kahm (東醫寶鑑) that were quoted from the So Moon (素問) and the Young Chu (靈樞). Mainly most of quoted sentences were same with original texts. The principal contents of this study can be summarized as follows. First, there are a few cases that the phrases of Dong-Eui Bo Kahm become more distinct and minute than that of the So Moon and the Young Chu. Second, there are many cases that the phrases of Dong-Eui Bo Kahm become briefer than that of the So Moon and the Young Chu. Third. many synonyms and equivalents of the phrases of the So Moon and the Young Chu were used in Dong-Eui Bo Kahm. Forth, there are a few wrong words and incorrect phrases in Dong-Eui Bo Kahm. Fifth, there are many omissed words and added words in Dong-Eui Bo Kahm. But that quoted sentences have same meaning with original sentenses. Sixth, original text book names were recorded in the end of all sentenses of Dong-Eui Bo Kahm, but there were a few wrong text book names.

옻에 의한 全身性 接觸皮膚炎 1例에 대한 症例報告

조정연,원진희,강태희,이건업,송봉길,이상관 대한한방성인병학회 2000 韓方成人病學會誌 Vol.6 No.1

Systemic contact dermatitis may be produced by the systemic administration of a drug to an individual who has been previously sensitized by the topical application of the drug or related chemicals. Rhus is a hot and a warm property, and is toxic. In Korea, Combination of the rhus and chicken, as a traditional food, has been used for the treatment of diseases such as gastrointestinal disorders(peptic ulcer, gastritis etc), stomach chill, general weakness and so forth. We treated a 31 year-old male patient who complained of fever, chilling, itching, burning pain, edema and vesicle etc. he had frequent rhus dermatitis and took rhus with chicken before above symptoms occurred. He was diagnosed as systemic contact dermatitis due to rhus, and responded well to treatment with Hwabanhaedok-tang(化斑解毒湯) and steroid drug(predinisolone) etc.